Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets
Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity...
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Elsevier Ltd
2015
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| LEADER | 21568caa a22019217a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518204326.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
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| 024 | 7 | |2 cas |a C reactive protein, 9007-41-4; cholesterol, 57-88-5; estradiol, 50-28-2; Muellerian inhibiting factor, 80497-65-0; Anti-Mullerian Hormone; Cholesterol; Cyclooxygenase 2; Triglycerides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a RBOEA | ||
| 100 | 1 | |a Bazzano, M.V. | |
| 245 | 1 | 0 | |a Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| 260 | |b Elsevier Ltd |c 2015 | ||
| 270 | 1 | 0 | |m Elia, E.M.; Laboratorio de Biología Del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET-UBA), Cdad. Universitaria, Pabellón 2, Argentina; email: evelinmariel@gmail.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Müllerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals. © 2015 Reproductive Healthcare Ltd. |l eng | |
| 593 | |a Laboratorio de Biología Del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET-UBA), Cdad. Universitaria, Pabellón 2, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Morfología, Escuela de Ciencias Básicas, Universidad Del Valle, Cali, Colombia | ||
| 690 | 1 | 0 | |a ANTI-MULLERIAN HORMONE |
| 690 | 1 | 0 | |a FERTILITY |
| 690 | 1 | 0 | |a FOLLICULAR CYST |
| 690 | 1 | 0 | |a FOLLICULOGENESIS |
| 690 | 1 | 0 | |a C REACTIVE PROTEIN |
| 690 | 1 | 0 | |a CHOLESTEROL |
| 690 | 1 | 0 | |a CYCLOOXYGENASE 2 |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a MUELLERIAN INHIBITING FACTOR |
| 690 | 1 | 0 | |a TRIACYLGLYCEROL |
| 690 | 1 | 0 | |a CHOLESTEROL |
| 690 | 1 | 0 | |a CYCLOOXYGENASE 2 |
| 690 | 1 | 0 | |a MUELLERIAN INHIBITING FACTOR |
| 690 | 1 | 0 | |a TRIACYLGLYCEROL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CAFETERIA DIET |
| 690 | 1 | 0 | |a CHOLESTEROL BLOOD LEVEL |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DIET |
| 690 | 1 | 0 | |a DIET INDUCED OBESITY |
| 690 | 1 | 0 | |a ESTRADIOL BLOOD LEVEL |
| 690 | 1 | 0 | |a ESTRUS CYCLE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FEMALE FERTILITY |
| 690 | 1 | 0 | |a FOLLICLE CYST |
| 690 | 1 | 0 | |a HYPERGLYCEMIA |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a OVARIAN RESERVE |
| 690 | 1 | 0 | |a OVARY FUNCTION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a TRIACYLGLYCEROL BLOOD LEVEL |
| 690 | 1 | 0 | |a ADVERSE EFFECTS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BLOOD |
| 690 | 1 | 0 | |a COMPLICATION |
| 690 | 1 | 0 | |a INFERTILITY, FEMALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a WESTERN DIET |
| 690 | 1 | 0 | |a WISTAR RAT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTI-MULLERIAN HORMONE |
| 690 | 1 | 0 | |a CHOLESTEROL |
| 690 | 1 | 0 | |a CYCLOOXYGENASE 2 |
| 690 | 1 | 0 | |a DIET, WESTERN |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HYPERGLYCEMIA |
| 690 | 1 | 0 | |a INFERTILITY, FEMALE |
| 690 | 1 | 0 | |a OBESITY |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, WISTAR |
| 690 | 1 | 0 | |a TRIGLYCERIDES |
| 700 | 1 | |a Torelli, C. | |
| 700 | 1 | |a Pustovrh, M.C. | |
| 700 | 1 | |a Paz, D.A. | |
| 700 | 1 | |a Elia, E.M. | |
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