Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis
p53 is a widely conserved tumor suppressor protein that is frequently inactivated in human cancer. p53 functions primarily as a transcription factor regulating the expression of a growing repertoire of target genes. p53 integrates signals from many stress-activated pathways and is subject to multipl...
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Springer Berlin Heidelberg
2010
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| LEADER | 19565caa a22013937a 4500 | ||
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| 001 | PAPER-12931 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204309.0 | ||
| 008 | 190411s2010 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84900600620 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Giono, L.E. | |
| 245 | 1 | 0 | |a Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis |
| 260 | |b Springer Berlin Heidelberg |c 2010 | ||
| 270 | 1 | 0 | |m Manfredi, J.J.; Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, United States; email: james.manfredi@mssm.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a p53 is a widely conserved tumor suppressor protein that is frequently inactivated in human cancer. p53 functions primarily as a transcription factor regulating the expression of a growing repertoire of target genes. p53 integrates signals from many stress-activated pathways and is subject to multiple posttranslational modifications. Phosphorylation and acetylation have been implicated in the regulation of p53 stability and activity. In response to DNA damage, hypoxia, oncogene activation and other types of stress, activated p53 triggers a variety of cellular programs, often in a stimuli- and cell type-specific manner. In particular, the role of p53 in cell growth arrest and apoptosis is criticial for its tumor suppressor activity. © 2010 Springer-Verlag Berlin Heidelberg. |l eng | |
| 593 | |a Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, United States | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 700 | 1 | |a Manfredi, J.J. | |
| 773 | 0 | |d Springer Berlin Heidelberg, 2010 |h pp. 375-395 |p Sign. Transduction: Pathways, Mechanisms and Dis. |z 9783642021114 |t Signal Transduction: Pathways, Mechanisms and Diseases | |
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