Platelet function and antithrombins in hyperlipoproteinemia type IIa
Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggrega...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1981
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09589caa a22011057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-1292 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203038.0 | ||
| 008 | 190411s1981 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0019433531 | |
| 024 | 7 | |2 cas |a antithrombin, 9000-94-6; cholesterol, 57-88-5; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; Adenosine Diphosphate, 58-64-0; Antithrombins; Calcium, 7440-70-2; Cholesterol, 57-88-5; Epinephrine, 51-43-4; Heparin Antagonists; Thromboplastin, 9035-58-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a THBRA | ||
| 100 | 1 | |a Molinas, F.C. | |
| 245 | 1 | 0 | |a Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| 260 | |c 1981 | ||
| 270 | 1 | 0 | |m Molinas, F.C. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Mustard, Packham, The role of blood and platelets in atherosclerosis and the complications of atherosclerosis (1975) Thromb. Diathes. Haemorrh., 33, pp. 444-456 | ||
| 504 | |a Spector, Hoak, Fatty acids, platelets, and microcirculatory obstruction (1975) Science, 190, pp. 490-491 | ||
| 504 | |a Connor, Hoak, Warner, Massive thrombosis produced by fatty acid suspension (1963) J. Clin. Invest., 42, pp. 860-866 | ||
| 504 | |a Haslam, Role of adenosine diphosphate in the aggregation of human blood platelets by thrombin and by fatty acids (1964) Nature, 23, pp. 765-768 | ||
| 504 | |a Carvalho, Colman, Lees, Platelet function in hyperlipoproteinemia (1974) New Engl. J. Med., 290, pp. 434-438 | ||
| 504 | |a Shanttil, Anaya-Galindo, Bennet, Colman, Cooper, Platelet hypersensitivity induced by cholesterol incorporation (1975) J. Clin. Invest., 55, pp. 636-643 | ||
| 504 | |a Joist, Baker, Schönfeld, Increased in vivo and in vitro platelet function in type II and type IV hyperlipoproteinemia (1979) Thromb. Res., 15, pp. 95-108 | ||
| 504 | |a Nordøy, Rodset, Platelet phospholipids and their function in patients with ischemic heart disease (1970) Acta Medica Scandinavica, 188, pp. 133-137 | ||
| 504 | |a Nordøy, Rodset, Platelet function and platelet phospholipids in patients with hyperbetalipoproteinemia (1971) Acta Medica Scandinavica, 189, pp. 385-389 | ||
| 504 | |a Third, Lowe, Drummond, Brenner, Lawrie, Prentice, Increased plasma fibrinogen and platelet aggregates in type II hyperlipoproteinemia (abstr.) (1979) Thromb. Haemostas., 42 | ||
| 504 | |a Kim, Merskey, Deming, Adel, Wolinsky, Clarkson, Lofland, Hyperlipidemia, hypercoagulability and accelerated thrombosis: Studies in congenitally hyperlipemic rats and in rats and monkeys with induced hyperlipidemia (1976) Blood, 47, pp. 275-286 | ||
| 504 | |a Wu, Armstrong, Hoak, Megan, Platelet aggregates in hypercholesterolemic rhesus monkeys (1975) Thromb. Res., 7, pp. 917-924 | ||
| 504 | |a Oversohl, Bassenge, Schmid-Schonbein, Effect of hyperlipidemia and stress on platelet aggregation in rabbits (1975) Thromb. Res., 7, pp. 481-492 | ||
| 504 | |a Steele, Rainwater, Effect of dietary and pharmacologic alteration of serum lipids on platelet survival time (1978) Circulation, 58, pp. 365-367 | ||
| 504 | |a Huang, Chen, Wefler, Rafferty, A stable reagent for the Lieberman- Burchard reaction (1961) Application to rapid serum cholesterol determination, 33, pp. 1405-1407. , Twelfth edition, Anal. Chem | ||
| 504 | |a Gottfried, Rosenberg, Improved manual spectrophotometric procedure for determination of serum triglycerides (1973) Clin. Chem., 19, pp. 1077-1078 | ||
| 504 | |a Molinas, Inhibition by phenol and phenolic acids of platelet release reaction (1973) Thromb. Diathes. Haemorrh., 30, pp. 334-338 | ||
| 504 | |a Brecher, Cronkite, Morphology and enumeration of human blood platelets (1955) J. Appl. Physiol., 3, pp. 365-377 | ||
| 504 | |a Born, Aggregation of blood platelets by adenosine diphosphate and its reversal (1962) Nature, 194, pp. 927-929 | ||
| 504 | |a O'Brien, Platelet aggregation 1 Some effects of the adenosine diphosphates thrombin and cocaine upon platelet adhesiveness (1962) Journal of Clinical Pathology, 15, pp. 446-455 | ||
| 504 | |a Zucker, Borrelli, Platelet clumping produced by connective tissue suspension and by collagen (1962) Experimental Biology and Medicine, 109, pp. 779-787. , Twelfth edition | ||
| 504 | |a Sanchez Avalos, Molinas, Factor plaquetario 4 (antiheparina): Nuevo método de estudio (abstr.) (1971) Medicina, 30, p. 604 | ||
| 504 | |a Rabiner, Hrodek, Platelet factor 3 in normal subjects and patients with renal failure (1968) J. Clin. Invest., 47, pp. 901-912 | ||
| 504 | |a Hardisty, Hutton, The kaolin clotting time of platelet rich plasma: A test of platelet factor 3-availability (1965) Brit. J. Haematol., 11, pp. 258-268 | ||
| 504 | |a Ødegard, Lie, Abildgaard, Heparin cofactor activity measured with an amidolytic method (1975) Thromb. Res., 6, pp. 287-294 | ||
| 504 | |a Biggs, Denson, Akman, Borret, Haddon, Antithrombin III, anti factor Xa and heparin (1970) Brit, J. Haematol., 19, pp. 283-305 | ||
| 504 | |a Quick, (1957) Hemorrhagic Diseases, p. 376. , Lea & Febiger, Philadelphia | ||
| 504 | |a Proctor, Rapaport, The partial thromboplastin time with kaolin (1961) A simple screening test for first stage plasma clotting factor deficiencies, 36, pp. 212-219. , Twelfth edition, Am. J. Clin. Path | ||
| 504 | |a Schwartz, (1966) Méthodes statistiques a l'usage des Medicínes et des biologistes, pp. 151-166. , Twelfth edition, Medicales Flammarion, Paris | ||
| 504 | |a O'Brien, Etherington, Jamieson, Acute platelet changes after large meals of saturated and unsaturared fats (1976) Lancet, 1, pp. 878-880 | ||
| 504 | |a Molinas, Drucker, Finkielman, Alvarez Reynolds, Agregación plaquetaria y actividad antiheparínica plasmática en hipercolesterolémicos. (abstr.) (1976) Medicina, 36, p. 572 | ||
| 504 | |a Zahavi, Betterridge, Jones, Galton, Leyton, Kakkar, β-Thromboglobulin, platelet factor 4 and malondialdehyde formation in hyperlipemic patients (1979) Thromb. Haemostas., 42 | ||
| 504 | |a Carvalho, Lees, Vaillancourt, Cabral, Weinberg, Colman, Intravascular coagulation in hyperlipidemia (1976) Thrombosis Research, 8, pp. 843-857 | ||
| 504 | |a Innerfield, Goldficher, Reiner-Reiss, Greenberg, Serum antithrombin in coronary-artery disease (1976) Am. J. Clin. Path., 65, pp. 64-68 | ||
| 504 | |a Stormorken, Eriksen, Plasma antithrombin III and factor VIII antigen in relation to angiographic findings, angina and blood groups in middle-aged men (1977) Thromb. Haemostas, 38, pp. 874-880 | ||
| 520 | 3 | |a Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggregation elicited by bovine factor VIII were significantly lower in hypercholesterolemic patients, who also disclosed an increased plasmatic antiheparin activity. This plasmatic antiheparin activity was inversely correlated to plasmatic cholesterol concentration, (r = -0.50, p<0.01). PF3 and PF4 were normal in patients with type IIa hyperlipoproteinemia. AntiFXa, antithrombin III, and heparin cofactor were also determined. Heparin cofactor was found to be significantly lower in hypercholesterolemic patients than in controls, and inversely correlated to plasmatic cholesterol concentration (r = -0.51, p<0.05). These observations suggest that the thrombotic tendency in hypercholesterolemia may be related to a decrease of plasmatic heparin cofactor. © 1981. |l eng | |
| 593 | |a Instituto de Investigaciones Médicas, Facultad de Medicina, Donato Alvarez 3150, y Cátedra de Análisis Clínicos, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTITHROMBINS |
| 690 | 1 | 0 | |a HYPERLIPOPROTEINEMIA |
| 690 | 1 | 0 | |a PLATELET AGGREGATION |
| 690 | 1 | 0 | |a ANTITHROMBIN |
| 690 | 1 | 0 | |a CHOLESTEROL |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a BLOOD AND HEMOPOIETIC SYSTEM |
| 690 | 1 | 0 | |a ETIOLOGY |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a HYPERLIPOPROTEINEMIA TYPE 2A |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a THROMBOCYTE AGGREGATION |
| 690 | 1 | 0 | |a ADENOSINE DIPHOSPHATE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANTITHROMBINS |
| 690 | 1 | 0 | |a BLOOD COAGULATION |
| 690 | 1 | 0 | |a BLOOD PLATELETS |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CHOLESTEROL |
| 690 | 1 | 0 | |a EPINEPHRINE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEPARIN ANTAGONISTS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a HYPERLIPOPROTEINEMIA TYPE II |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MIDDLE AGED |
| 690 | 1 | 0 | |a PLATELET AGGREGATION |
| 690 | 1 | 0 | |a THROMBOPLASTIN |
| 700 | 1 | |a Drucker, E. | |
| 700 | 1 | |a Kordich, L. | |
| 700 | 1 | |a Alvarez Reynolds, M. | |
| 700 | 1 | |a Finkielman, S. | |
| 773 | 0 | |d 1981 |g v. 22 |h pp. 427-435 |k n. 4 |p Thromb. Res. |x 00493848 |t Thrombosis Research | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019433531&doi=10.1016%2f0049-3848%2881%2990104-3&partnerID=40&md5=83339132bb226c612f7826fe74145d5d |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0049-3848(81)90104-3 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00493848_v22_n4_p427_Molinas |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v22_n4_p427_Molinas |y Registro en la Biblioteca Digital |
| 961 | |a paper_00493848_v22_n4_p427_Molinas |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 62245 | ||