New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis
Cysticercosis caused by Taenia solium frequently affects human health and rustic porciculture. Cysticerci may localize in the central nervous system of humans causing neurocysticercosis, a major health problem in undeveloped countries. Prevalence and intensity of this disease in pigs and humans are...
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2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 19341caa a22018137a 4500 | ||
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| 001 | PAPER-12753 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131859.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036661871 | |
| 024 | 7 | |2 cas |a Cholera Toxin, 9012-63-9; Recombinant Fusion Proteins; Vaccines, Subunit | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Sciutto, E. | |
| 245 | 1 | 0 | |a New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis |
| 260 | |c 2002 | ||
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Cysticercosis caused by Taenia solium frequently affects human health and rustic porciculture. Cysticerci may localize in the central nervous system of humans causing neurocysticercosis, a major health problem in undeveloped countries. Prevalence and intensity of this disease in pigs and humans are related to social factors (poor personal hygiene, low sanitary conditions, rustic rearing of pigs, open fecalism) and possibly to biological factors such as immunity, genetic background, and gender. The indispensable role of pigs as an obligatory intermediate host in the life cycle offers the possibility of interfering with transmission through vaccination of pigs. An effective vaccine based on three synthetic peptides against pig cysticercosis has been successfully developed and proved effective in experimental and field conditions. The well-defined peptides that constitute the cysticercosis vaccine offer the possibility to explore alternative forms of antigen production and delivery systems that may improve the cost/benefit of this and other vaccines. Encouraging results were obtained in attempts to produce large amounts of these peptides and increased its immunogenicity by expression in recombinant filamentous phage (M13), in transgenic plants (carrots and papaya), and associated to bacterial immunogenic carrier proteins. © 2002 IMSS. Published by Elsevier Science Inc. |l eng | |
| 536 | |a Detalles de la financiación: Fundación Miguel Alemán, A.C. | ||
| 536 | |a Detalles de la financiación: Benemérita Universidad Autónoma de Puebla | ||
| 536 | |a Detalles de la financiación: Howard Hughes Medical Institute | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Ciencia y Tecnología, G25955m | ||
| 536 | |a Detalles de la financiación: British Council | ||
| 536 | |a Detalles de la financiación: Universidad Nacional Autónoma de México, UNAM, IN212798 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Ciencia y Tecnología | ||
| 536 | |a Detalles de la financiación: The authors thank N. Villalobos, G. Acero, M. Baca, N. Copitin, A. Guevara, and G. Sánchez for their technical assistance and are grateful for the support of the Benemérita Universidad Autónoma de Puebla, the Health Ministry of the State of Puebla, and Elvira Salazar for help with the English version of the manuscript. This investigation was supported by Consejo Nacional de Ciencia y Tecnologı́a (CONACYT, México) grant G25955m, the Fundación Miguel Alemán (México), the British Council, Dirección General de Personal Académico of the Universidad Nacional Autónoma de México (UNAM) grant IN212798, and the Howard Hughes Medical Institute. | ||
| 593 | |a Departamento de Inmunología, Inst. de Investigaciones Biomedicas, Mexico City, Mexico | ||
| 593 | |a Departamento de Biología Celular, Instituto de Fisiología Celular, Mexico City, Mexico | ||
| 593 | |a Departamento de Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico | ||
| 593 | |a Unidad de Medicina Biomolecular, Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico | ||
| 593 | |a Unidad de Investigación Médica en Inmunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico | ||
| 593 | |a Departamento de Ingeniería Genética de Plantas, Unidad de Biotecnología e Ingeniería Genética de Plantas, Centro de Investigaciones y de Estudios, Avanzados del Instituto Politécnico Nacional (CINVESTAV del IPN), Irapuato, Guanajuato, Mexico | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Bioquímicas Dr. Luis F. Leloir, Fundación Campomar, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTIGEN DELIVERY |
| 690 | 1 | 0 | |a CYSTICERCOSIS |
| 690 | 1 | 0 | |a SYNTHETIC VACCINE |
| 690 | 1 | 0 | |a TAENIA CRASSICEPS |
| 690 | 1 | 0 | |a TAENIA SOLIUM |
| 690 | 1 | 0 | |a VACCINATION |
| 690 | 1 | 0 | |a CARRIER PROTEIN |
| 690 | 1 | 0 | |a VACCINE |
| 690 | 1 | 0 | |a BACTERIOPHAGE |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a CONFERENCE PAPER |
| 690 | 1 | 0 | |a COST BENEFIT ANALYSIS |
| 690 | 1 | 0 | |a COST EFFECTIVENESS ANALYSIS |
| 690 | 1 | 0 | |a CYSTICERCOSIS |
| 690 | 1 | 0 | |a DEVELOPING COUNTRY |
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a DISEASE TRANSMISSION |
| 690 | 1 | 0 | |a HOST PARASITE INTERACTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNITY |
| 690 | 1 | 0 | |a IMMUNOGENICITY |
| 690 | 1 | 0 | |a INFECTION PREVENTION |
| 690 | 1 | 0 | |a INFECTION RATE |
| 690 | 1 | 0 | |a NEUROCYSTICERCOSIS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PERSONAL HYGIENE |
| 690 | 1 | 0 | |a PIG FARMING |
| 690 | 1 | 0 | |a SEX DIFFERENCE |
| 690 | 1 | 0 | |a SWINE |
| 690 | 1 | 0 | |a TAENIA SOLIUM |
| 690 | 1 | 0 | |a TRANSGENIC PLANT |
| 690 | 1 | 0 | |a VACCINATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CHOLERA TOXIN |
| 690 | 1 | 0 | |a CYSTICERCOSIS |
| 690 | 1 | 0 | |a CYSTICERCUS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a PLANTS, GENETICALLY MODIFIED |
| 690 | 1 | 0 | |a PLASMIDS |
| 690 | 1 | 0 | |a RECOMBINANT FUSION PROTEINS |
| 690 | 1 | 0 | |a SWINE |
| 690 | 1 | 0 | |a SWINE DISEASES |
| 690 | 1 | 0 | |a VACCINATION |
| 690 | 1 | 0 | |a VACCINES, SUBUNIT |
| 700 | 1 | |a Fragoso, G. | |
| 700 | 1 | |a Manoutcharian, K. | |
| 700 | 1 | |a Gevorkian, G. | |
| 700 | 1 | |a Rosas-Salgado, G. | |
| 700 | 1 | |a Hernández-Gonzalez, M. | |
| 700 | 1 | |a Herrera-Estrella, L. | |
| 700 | 1 | |a Cabrera-Ponce, J.L. | |
| 700 | 1 | |a López-Casillas, F. | |
| 700 | 1 | |a González-Bonilla, C. | |
| 700 | 1 | |a Santiago-Machuca, A. | |
| 700 | 1 | |a Ruíz-Pérez, F. | |
| 700 | 1 | |a Sánchez, J. | |
| 700 | 1 | |a Goldbaum, F. | |
| 700 | 1 | |a Aluja, A. | |
| 700 | 1 | |a Larralde, C. | |
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