Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo
1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase....
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1992
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08121caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12673 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204251.0 | ||
| 008 | 190411s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026637403 | |
| 024 | 7 | |2 cas |a 5 aminolevulinate synthase, 9037-14-3; acrolein, 107-02-8; allylisopropylacetamide, 299-78-5; cyclophosphamide, 50-18-0; cytochrome P450, 9035-51-2; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; porphyrin, 24869-67-8; proadifen, 302-33-0, 62-68-0; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Acrolein, 107-02-8; Allylisopropylacetamide, 299-78-5, 50-06-6; Cyclophosphamide, 50-18-0, 9035-51-2; Cytochrome P-450 Enzyme System, 9035-51-2; Phenobarbital, 50-06-6; Porphyrins; Proadifen, 302-33-0, 50-06-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Cochón, A.C. | |
| 245 | 1 | 0 | |a Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m de Viale, L.C.S.M. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Clarke, Waxman, Oxidative metabolism of cyclophosphamide. Identification of the heptatic monooxygenase catalysts of drug activation (1989) Cancer Res., 49, pp. 2344-2350 | ||
| 504 | |a Colvin, (1982) Pharmacologies Principles of Cancer Treatment, pp. 276-308. , B Chabner, Saunders, Philadelphia | ||
| 504 | |a Hamilton, Bement, Sinclair, Sinclair, Wetterhahn, Expression of 5-aminolaevulinate synthase and cytochrorne P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem (1988) Biochem. J., 255, pp. 267-275 | ||
| 504 | |a LeBlanc, Waxman, Mechanisms of cyclophosphamide action on hepatic P-450 expression (1990) Cancer Res., 50, pp. 5720-5726 | ||
| 504 | |a Lowry, Rosenbrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Makinodan, Santos, Quim, Immunosuppressive drugs (1970) Pharmacol. Rev., 22, pp. 189-199 | ||
| 504 | |a Manzione, Wolkoff, Sassa, Development of porphyria cutanea tarda after treatment with cyclophosphamide (1988) Gastroenterology, 95, pp. 1119-1122 | ||
| 504 | |a Marinello, Gurtoo, Struck, Paul, Denaturation of cytochrome P-450 by cyclophosphamide metabolites (1978) Biochem. Biophys. Res. Comm., 83, pp. 1347-1353 | ||
| 504 | |a Marks, McCluskey, Mackie, Riddick, James, Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450 (1988) FASEB J., 2, pp. 2774-2783 | ||
| 504 | |a Marver, Tschudy, Perlroth, Collins, δ-Aminolevulinic acid synthetase I. Studies in liver homogenates (1966) J. biol. Chem., 241, pp. 2803-2809 | ||
| 504 | |a Meyer, Schmid, Metabolic basis of inherited diseases (1978) The Porphyrias, pp. 1164-1220. , J.B. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, McGraw-Hill, New York | ||
| 504 | |a Misra, Lorr, Bloom, Cyclophosphamide metabolism in the primary immune organ of the chick: assays of drug activation, P-450 expression and aldehyde dehydrogenase (1991) Arch. Toxicol., 65, pp. 32-38 | ||
| 504 | |a Moormeier, Williams, Kaminer, Garner, Bitram, High-dose tri-alkylator chemotherapy with autologous stem cell rescue in patients with refractory malignancies (1990) J. natl Cancer Inst., 82, pp. 29-34 | ||
| 504 | |a Omura, Sato, The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature (1964) J. biol. Chem., 239, pp. 2370-2378 | ||
| 504 | |a Ortiz de Montellano, Correia, Suicidal destruction of cytochrome P-450 during oxidative drug metabolism (1983) Annual Review of Pharmacology and Toxicology, 23, pp. 481-503 | ||
| 504 | |a Rifkind, Drug-induced exacerbations of porphyria (1976) Primary Care, 3, pp. 665-685 | ||
| 504 | |a San Martin de Viale, Rios de Molina M. del, Wainstok de Calmanovici, Tomio, Porphyrins and porphyrinogen carboxylyase in hexachlorobenzene-induced porphyria (1977) Biochem. J., 168, pp. 393-400 | ||
| 504 | |a Sladek, Therapeutic efficacy of cyclophosphamide as a function of its metabolism (1972) Cancer Res., 32, pp. 535-542 | ||
| 504 | |a Wainstok de Calmanovici, San Martin de Viale, Effect of some antineoplastics on metabolic heme pathway (1988) Int. J. Biochem., 20, pp. 1015-1020 | ||
| 504 | |a Wilson, Shelley, Belch, Brandes, Bergsagel, Klimo, White, Willan, Weekly cyclophosphamide and alternate-day prednisone an effective secondary therapy in multiple myeloma (1987) Cancer Treat Rep, 71, pp. 981-982 | ||
| 520 | 3 | |a 1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein. © 1992. |l eng | |
| 593 | |a Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nunez, 1428, Buenos Aires, Argentina, Argentina | ||
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a ACROLEIN |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a DRUG METABOLITE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a PROADIFEN |
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a ACROLEIN |
| 690 | 1 | 0 | |a ALLYLISOPROPYLACETAMIDE |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EMBRYO |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a CHEMICAL STRUCTURE |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a ENZYMOLOGY |
| 690 | 1 | 0 | |a GESTATIONAL AGE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ACROLEIN |
| 690 | 1 | 0 | |a ALLYLISOPROPYLACETAMIDE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a CYCLOPHOSPHAMIDE |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a GESTATIONAL AGE |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MOLECULAR STRUCTURE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a PROADIFEN |
| 653 | 0 | 0 | |a skf 525a, smith kline and french, United States |
| 700 | 1 | |a de Viale, L.C.S.M. | |
| 700 | 1 | |a de Calmanovici, R.W. | |
| 773 | 0 | |d 1992 |g v. 102 |h pp. 143-148 |k n. 1 |x 03064492 |w (AR-BaUEN)CENRE-2750 |t Comparative Biochemistry and Physiology. Part C, Comparative | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0742-8413(92)90056-D |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03064492_v102_n1_p143_Cochon |y Handle |
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| 999 | |c 73626 | ||