Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily
Cruzipain, the major cysteine proteinase from Trypanosoma cruzi epimastigotes, purified to a sequentially pure form, exists in multiple forms with pI values between 3.7 and 5.1, and an apparent molecular mass of 41 kDa. The enzyme is stable between pH 4.5-9.5. Cruzipain was found to be rapidly and t...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1995
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08725caa a22012977a 4500 | ||
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| 001 | PAPER-12444 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204238.0 | ||
| 008 | 190411s1995 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0029161123 | |
| 024 | 7 | |2 cas |a cystatin, 81989-95-9; cysteine proteinase, 37353-41-6; proteinase inhibitor, 37205-61-1; stefin A, 107544-29-6; stefin B, 106178-19-2; cruzipain, EC 3.4.22.-; Cystatins; Cysteine Endopeptidases, EC 3.4.22; Recombinant Proteins; stefin A, 107544-29-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FEBLA | ||
| 100 | 1 | |a Stoka, V. | |
| 245 | 1 | 0 | |a Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily |
| 260 | |c 1995 | ||
| 270 | 1 | 0 | |m Stoka, V.; Department of Biochemistry and Molecular Biology, J. Stefan Institute, Jamova 39, 61111 Ljubljana, Slovenia |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Brocklehurst, Willenbrock, Salih, (1987) Hydrolytic enzymes, pp. 39-155. , A. neuberger, K. Brocklehurst, Elsevier, Amsterdam | ||
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| 504 | |a Lindahl, Alriksson, Jörnvall, Björk, (1988) Biochemistry, 27, pp. 5074-5082 | ||
| 504 | |a Cimerman, (1993) PhD Thesis, , University of Ljubljana | ||
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| 504 | |a Turk, Čolic, Stoka, Turk, (1994) FEBS Lett., 339, pp. 155-159 | ||
| 504 | |a Martínez, Cazzulo, (1992) FEMS Microbiol. Lett., 95, pp. 225-230 | ||
| 504 | |a Turk, Dolenc, Žerovnik, Turk, Gubenšek, Turk, (1994) Biochemistry, 33, pp. 14800-14806 | ||
| 504 | |a Mbwara, Gumm, Shaw, Lonsdale-Eccles, (1992) Eur. J. Biochem., 204, pp. 371-379 | ||
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| 520 | 3 | |a Cruzipain, the major cysteine proteinase from Trypanosoma cruzi epimastigotes, purified to a sequentially pure form, exists in multiple forms with pI values between 3.7 and 5.1, and an apparent molecular mass of 41 kDa. The enzyme is stable between pH 4.5-9.5. Cruzipain was found to be rapidly and tightly inhibited by various protein inhibitors of the cystatin superfamily (kass = 1.7-79 × 106M-1s-1, Kd = 1.4-72 pM). These results suggest a possible defensive role for the host's cystatins after parasite infection, and may be of use for the design of new therapeutic drugs. © 1995. |l eng | |
| 536 | |a Detalles de la financiación: SAREC | ||
| 536 | |a Detalles de la financiación: 4212 | ||
| 536 | |a Detalles de la financiación: Ministry of Science and Technology of the People's Republic of China | ||
| 536 | |a Detalles de la financiación: 32.0433/94 | ||
| 536 | |a Detalles de la financiación: Acknowledgements: We gratefully acknowledge Prof. Dr. Roger Pain and Dr. Boris Turk lbr their advice and critical reading of the manuscript, Dr. Iztok Dolenc for helpful suggestions and Dr. Anka Ritonja tbr N-terminal sequencing. Recombinant human cystatin C was kindly provided by Dr. Nina Cimerman (Krka Pharmaceuticals, Slovenia). This work was supported by grants from the Ministry of Science and Technology of the Republic of Slovenia, the Swedish Medical Council (project no. 4212), the Swedish Council for Forestry and Agricultural Research (project no. 32.0433/94), the Swedish Agency for Research Cooperation with Developing Countries (SAREC), and Fundaci6n An-torchas (Argentina). | ||
| 593 | |a Department of Biochemistry and Molecular Biology, J. Stefan Institute, Jamova 39, 61111 Ljubljana, Slovenia | ||
| 593 | |a Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Box 575, S-751 23 Uppsala, Sweden | ||
| 593 | |a Instituto de Investigaciones Bioquímicas 'Luis F. Leloir', Fundación Campomar-CONICET, Facultad de Ciencias Exactas y Naturales, Antonio Machado 151, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CRUZIPAIN |
| 690 | 1 | 0 | |a CYSTATIN |
| 690 | 1 | 0 | |a CYSTEINE PROTEINASE |
| 690 | 1 | 0 | |a INHIBITION |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a CRUZIPAIN |
| 690 | 1 | 0 | |a CYSTATIN |
| 690 | 1 | 0 | |a CYSTATIN C |
| 690 | 1 | 0 | |a CYSTEINE PROTEINASE |
| 690 | 1 | 0 | |a KININOGEN |
| 690 | 1 | 0 | |a PROTEINASE INHIBITOR |
| 690 | 1 | 0 | |a STEFIN A |
| 690 | 1 | 0 | |a STEFIN B |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a ENZYME PURIFICATION |
| 690 | 1 | 0 | |a ENZYME STRUCTURE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHICKENS |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a CYSTATINS |
| 690 | 1 | 0 | |a CYSTEINE ENDOPEPTIDASES |
| 690 | 1 | 0 | |a ELECTROPHORESIS, POLYACRYLAMIDE GEL |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a ISOELECTRIC FOCUSING |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MOLECULAR WEIGHT |
| 690 | 1 | 0 | |a RECOMBINANT PROTEINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 650 | 1 | 7 | |2 spines |a PH |
| 700 | 1 | |a Nycander, M. | |
| 700 | 1 | |a Lenarčič, B. | |
| 700 | 1 | |a Labriola, C. | |
| 700 | 1 | |a Cazzulo, J.J. | |
| 700 | 1 | |a Björk, I. | |
| 700 | 1 | |a Turk, V. | |
| 773 | 0 | |d 1995 |g v. 370 |h pp. 101-104 |k n. 1-2 |p FEBS Lett. |x 00145793 |w (AR-BaUEN)CENRE-552 |t FEBS Letters | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029161123&doi=10.1016%2f0014-5793%2895%2900798-E&partnerID=40&md5=2e41b4b35610061a41d08fc059734540 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0014-5793(95)00798-E |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00145793_v370_n1-2_p101_Stoka |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v370_n1-2_p101_Stoka |y Registro en la Biblioteca Digital |
| 961 | |a paper_00145793_v370_n1-2_p101_Stoka |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 73397 | ||