Endothelin-1 -induced incorporation of cholesterol into rat adrenals

The effect of endothelin-1 (ET-1) on cholesterol uptake by adrenal cortex was evaluated through several experimental approaches: infusion of ET-1 followed by measurement of endogenous cholesterol in excised adrenals; infusion of ET-1 followed by tritiated cholesterol incorporation into adrenal quart...

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Autor principal: Romero, D.G
Otros Autores: Pecci, A., Lantos, C.P, Cozza, E.N
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Inc. 1996
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
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024 7 |2 scopus  |a 2-s2.0-0030007702 
024 7 |2 cas  |a Aldosterone, 52-39-1; Aminoglutethimide, 125-84-8; Cholesterol, 57-88-5; Endothelin-1 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a STEDA 
100 1 |a Romero, D.G. 
245 1 0 |a Endothelin-1 -induced incorporation of cholesterol into rat adrenals 
260 |b Elsevier Inc.  |c 1996 
270 1 0 |m Cozza, E.N.; Departamento de Química Biologica, Facultad de Cs. Exactas y Naturales - UBA, Ciudad Universitaria, Pab 2, Piso 4, 1428-Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Yanasigawa, M., Kurihara, H., Kimura, S., Kobayashi M, T.Y., Mitsui, Y., Yazaki, Y., Goto, K., Masaki, T., A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) Nature, 232, pp. 411-415 
504 |a Inoue, A., Yanasigawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K., Masaki, T., The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes (1989) Proc Natl Acad Sci USA, 86, pp. 2863-2867 
504 |a Yanasigawa, M., Inoue, A., Ishikawa, T., Kasuya, Y., Kimura, S., Kumagaye, S.I., Nakajima, K., Masaki, T., Primary structure, synthesis and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide (1988) Proc Natl Acad Sci USA, 85, pp. 6964-6967 
504 |a Kloog, Y., Ambar, I., Sokolovsky, M., Kochva, E., Wollberg, Z., Sarafotoxin, a novel vasoconstrictor peptide: Phosphoinositide hydrolysis in rat heart and brain (1988) Science, 242, pp. 268-270 
504 |a Ambar, I., Kloog, Y., Kochva, E., Wollberg, Z., Bdolah, A., Oron, U., Sokolovsky, M., Characterization and localization of a novel neuroreceptor for the peptide sarafotoxin (1988) Biochem Biophys Res Commun, 157, pp. 1104-1110 
504 |a Cozza, E.N., Gomez-Sanchez, C.E., Effects of endothelin-1 on its receptor concentration and thymidine incorporation in calf adrenal zone glomerulosa cells: A comparative study with phorbol esters (1990) Endocrinology, 127, pp. 549-554 
504 |a Davenport, A.P., Nunez, D.J., Hall, J.A., Kaumann, A.J., Brown, M.J., Autoradiographical localization of binding sites for porcine [125I]-endothelin-1 in humans, pigs and rats: Functional relevance in humans (1989) J Cardiovasc Pharmacol, 13, pp. 5166-5170 
504 |a Cozza, E.N., Gomez-Sanchez, C.E., Foecking, M.F., Chiou, S., Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion (1989) J Clin Invest, 84, pp. 1032-1035 
504 |a Morishita, R., Higaki, J., Ogihara, T., Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells (1989) Biochem Biophys Res Commun, 160, pp. 628-632 
504 |a Hinson, J.P., Vinson, G.P., Kapas, S., Teja, R., The role of endothelin in the control of adrenocortical function: Stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells (1991) J Endocrinol, 128, pp. 275-280 
504 |a Mazzocchi, G., Rebuffat, P., Meneghelli, V., Malendowicz, L., Kasprzak, A., Nussdorfer, G.G., Effects of prolonged infusion with endothelin-1 on the function and morphology of rat adrenal cortex (1991) Peptides, 11, pp. 767-772 
504 |a Mazzocchi, G., Malendowicz, L., Nussdorfer, G.G., Endothelin-1 acutely stimulates the secretory activity of rat zona glomerulosa cells (1991) Peptides, 11, pp. 763-765 
504 |a Cozza, E.N., Chiou, S., Gomez-Sanchez, C.E., Endothelin-1 potentiation of angiotensin II stimulation of aldosterone secretion (1992) Am J Physiol, 262, pp. R85-R89 
504 |a Cozza, E.N., Gomez-Sanchez, C.E., Mechanism of the ET-1 potentiation of angiotensin II stimulation of aldosterone production in calf adrenal glomerulosa cell cultures (1993) Am J Physiol, 265, pp. E179-E183 
504 |a Rosolowsky, L.J., Campbell, W.B., Endothelin enhances adrenocorticotropin-stimulated aldosterone release from cultured bovine adrenal cells (1990) Endocrinology, 126, pp. 1860-1866 
520 3 |a The effect of endothelin-1 (ET-1) on cholesterol uptake by adrenal cortex was evaluated through several experimental approaches: infusion of ET-1 followed by measurement of endogenous cholesterol in excised adrenals; infusion of ET-1 followed by tritiated cholesterol incorporation into adrenal quarters in vitro; coinfusion of ET-1 with tritiated cholesterol-enriched serum and determination of adrenal-associated radioactivity; and tritiated cholesterol incorporation in incubations of adrenal cells. In all cases ET-1 increased cholesterol uptake. Subcellular fractionation showed an ET-1-mediated augmentation in mitochondrial fraction. This increase was mediated by the subpopulation B of adrenal receptors for ET-1. In addition, ET-1 also increased cytochrome P450-SCC (side-chain cleavage) activity. © 1996 by Elsevier Science Inc.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: This work was supported by grants from the Argentine Council for Scientific and Technological Research (CONICET) to the Programa de Regulaci6n Hormonal y Metab61ica (PRHOM), Universidad de Buenos Aires, and Fundaci6n Antorchas (Buenos Aires, Argentina). 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and PRHOM-CONICET, Buenos Aires, Argentina 
593 |a Departamento de Química Biologica, Facultad de Cs. Exactas y Naturales - UBA, Ciudad Universitaria, Pab 2, Piso 4, 1428-Buenos Aires, Argentina 
690 1 0 |a ADRENAL 
690 1 0 |a CHOLESTEROL 
690 1 0 |a ENDOTHELIN 
690 1 0 |a STEROIDOGENESIS 
690 1 0 |a 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE 
690 1 0 |a AMINOGLUTETHIMIDE 
690 1 0 |a CHOLESTEROL 
690 1 0 |a CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING) 
690 1 0 |a ENDOTHELIN 1 
690 1 0 |a ENDOTHELIN RECEPTOR 
690 1 0 |a ISOMERASE 
690 1 0 |a TRITIUM 
690 1 0 |a ADRENAL CELL 
690 1 0 |a ADRENAL CORTEX 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL TISSUE 
690 1 0 |a ARTICLE 
690 1 0 |a CELL CULTURE 
690 1 0 |a CELL FRACTIONATION 
690 1 0 |a CHOLESTEROL METABOLISM 
690 1 0 |a CHOLESTEROL TRANSPORT 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a INFUSION 
690 1 0 |a ISOTOPE LABELING 
690 1 0 |a MALE 
690 1 0 |a NONHUMAN 
690 1 0 |a RADIOACTIVITY 
690 1 0 |a RAT 
690 1 0 |a ADRENAL GLANDS 
690 1 0 |a ALDOSTERONE 
690 1 0 |a AMINOGLUTETHIMIDE 
690 1 0 |a ANIMALS 
690 1 0 |a CHOLESTEROL 
690 1 0 |a ENDOTHELIN-1 
690 1 0 |a INFUSIONS, INTRAVENOUS 
690 1 0 |a MALE 
690 1 0 |a RATS 
690 1 0 |a RATS, INBRED STRAINS 
690 1 0 |a ANIMALIA 
690 1 0 |a TRITIUM 
700 1 |a Pecci, A. 
700 1 |a Lantos, C.P. 
700 1 |a Cozza, E.N. 
773 0 |d Elsevier Inc., 1996  |g v. 61  |h pp. 317-322  |k n. 5  |p Steroids  |x 0039128X  |w (AR-BaUEN)CENRE-577  |t Steroids 
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