A Neurospora crassa morphological mutant showing reduced adenylate cyclase activity

A Neurospora crassa morphological mutation at the crisp locus is related to a low specific activity of adenylate cyclase. This observation was made in two different strains: FGSC No. 329 and FGSC No. 326, both carrying the crisp mutation (allele N. B 123). Crosses of these strains to others having t...

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Autor principal: Terenzi, H.F
Otros Autores: Flawiá, M.M, Torres, H.N
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1974
Acceso en línea:Registro en Scopus
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LEADER 06416caa a22009497a 4500
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024 7 |2 scopus  |a 2-s2.0-0016240020 
024 7 |2 cas  |a adenylate cyclase, 9012-42-4; bucladesine, 16980-89-5, 362-74-3; Adenosine Monophosphate, 61-19-8; Adenylate Cyclase, EC 4.6.1.1; Bucladesine, 362-74-3; Butyrates; Cyclic AMP, 60-92-4 
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030 |a BBRCA 
100 1 |a Terenzi, H.F. 
245 1 2 |a A Neurospora crassa morphological mutant showing reduced adenylate cyclase activity 
260 |c 1974 
270 1 0 |m Terenzi, H.F.; Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales, Obligado 2490 Buenos Aires (28), Argentina 
506 |2 openaire  |e Política editorial 
504 |a Flawiá, Torres, (1972) J. Biol. Chem., 247, pp. 6873-6879 
504 |a Flawiá, Torres, (1972) J. Biol. Chem., 247, pp. 6880-6883 
504 |a Flawiá, Torres, (1973) J. Biol. Chem., 248, pp. 4517-4520 
504 |a Flawiá, Torres, (1972) Biochim. Biophys. Acta, 289, pp. 428-432 
504 |a Flawiá, Tellez-Iñón, Torres, (1972) Biochemistry of the Glycosidic Linkage, pp. 541-571. , H.G. Pontis, R. Piras, Academic Press, New York 
504 |a Flawiá, Torres, (1972) Proc. Natl. Acad. Sci. U. S. A., 69, pp. 2870-2873 
504 |a Konijn, Van de Meene, Bonner, Barkley, (1967) Proc. Natl. Acad. Sci. U. S. A., 58, pp. 1152-1154 
504 |a Konijn, Barkley, Chang, Bonner, Cyclic Amp: A Naturally Occurring Acrasin in the Cellular Slime Molds (1968) The American Naturalist, 102, pp. 225-233 
504 |a Wold, Susuki, (1973) Biochem. Biophys. Res. Commun., 55, pp. 824-830 
504 |a Metzenberg, (1972) Ann. Rev. Genetics, 6, pp. 111-132 
504 |a Brody, Tatum, (1966) Proc. Natl. Acad. Sci. U. S. A., 56, pp. 1290-1297 
504 |a Scott, Tatum, (1970) Proc. Natl. Acad. Sci. U. S. A., 66, pp. 515-522 
504 |a Brody, Tatum, (1967) Proc. Natl. Acad. Sci. U. S. A., 58, pp. 923-930 
504 |a Mishra, Tatum, (1970) Proc. Natl. Acad. Sci. U. S. A., 66, pp. 638-645 
504 |a Brody, (1970) J. Bacteriol., 101, pp. 802-807 
504 |a Nyc, Brody, (1971) J. Bacteriol., 108, pp. 1310-1317 
504 |a Vogel, (1956) Microbial Genet. Bull., 13, pp. 42-43 
504 |a Ryan, Beadle, Tatum, The Tube Method of Measuring the Growth Rate of Neurospora (1943) American Journal of Botany, 30, pp. 784-799 
504 |a Gillie, (1968) J. Gen. Microbiol., 51, pp. 185-194 
504 |a Barrat, Ogata, (1972) Neurospora Newsletter, 19, pp. 34-105 
504 |a Emerson, (1963) Genetica, 34, pp. 162-182 
504 |a Perkins, New Markers and Multiple Point Linkage Data in Neurospora. (1959) Genetics, 44, pp. 1185-1208 
504 |a Perkins, Newmeyer, Taylor, Bennet, (1969) Genetica, 40, pp. 247-278 
520 3 |a A Neurospora crassa morphological mutation at the crisp locus is related to a low specific activity of adenylate cyclase. This observation was made in two different strains: FGSC No. 329 and FGSC No. 326, both carrying the crisp mutation (allele N. B 123). Crosses of these strains to others having the wild type allele yield isolates with the crisp phenotype all of them having low adenylate cyclase specific activity in crude extracts. The other phenotypes obtained showed wild type levels of specific activity. Addition of 3′, 5′ dibutyryl cyclic AMP to the FGSC No. 329 cultures increased four-fold mycelial growth rate and stimulated the formation of aerial hyphae. Simultaneously, uniform conidiation on the surface of the slant was inhibited by the cyclic AMP derivative. © 1974 Academic Press, Inc.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas 
536 |a Detalles de la financiación: Jane Coffin Childs Memorial Fund for Medical Research, JCC Fund 
536 |a Detalles de la financiación: Acknowledgements. This work was supported in part by grants from the Jane Coffin 5emorial Foundation for Medical Research, the University of Buenos Aires and the Consejo Nacional de Investigaciones Cientlficas y T~cnicas (Argentina). H.F.T. y H.N.T. are career investigators of the latter institution. The authors are grateful to Dr. Luis #. Leloir for advice and support and to all members of the Instituto de Investigaciones Bioqulmicas for helpful discussions and criticisms. 
593 |a Instituto de Investigaciones Bioquímicas Fundación Campomar, Facultad de Ciencias Exactas y Naturales, Obligado 2490 Buenos Aires (28), Argentina 
690 1 0 |a ADENYLATE CYCLASE 
690 1 0 |a BUCLADESINE 
690 1 0 |a FUNGUS 
690 1 0 |a GENETICS 
690 1 0 |a GROWTH 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a MICROORGANISM 
690 1 0 |a NEUROSPORA CRASSA 
690 1 0 |a THEORETICAL STUDY 
690 1 0 |a ADENOSINE MONOPHOSPHATE 
690 1 0 |a ADENYLATE CYCLASE 
690 1 0 |a ALLELES 
690 1 0 |a BUCLADESINE 
690 1 0 |a BUTYRATES 
690 1 0 |a CHROMOSOME MAPPING 
690 1 0 |a COMPARATIVE STUDY 
690 1 0 |a CROSSES, GENETIC 
690 1 0 |a CYCLIC AMP 
690 1 0 |a GENOTYPE 
690 1 0 |a MUTATION 
690 1 0 |a NEUROSPORA 
690 1 0 |a NEUROSPORA CRASSA 
690 1 0 |a PHENOTYPE 
690 1 0 |a SPECIES SPECIFICITY 
700 1 |a Flawiá, M.M. 
700 1 |a Torres, H.N. 
773 0 |d 1974  |g v. 58  |h pp. 990-996  |k n. 4  |p Biochem. Biophys. Res. Commun.  |x 0006291X  |w (AR-BaUEN)CENRE-905  |t Biochemical and Biophysical Research Communications 
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856 4 0 |u https://doi.org/10.1016/S0006-291X(74)80241-X  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_0006291X_v58_n4_p990_Terenzi  |y Handle 
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