Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver
In the present study we investigated the porphyrinogenic ability of 4 pesticides: chlordane, endosulfan, parathion and malathion, all of which are widely used in agriculture. In order to determine whether they affect the heme biosynthetic pathway we studied, in 17-day old chick embryo liver "in...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1982
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 07864caa a22009977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-1228 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203034.0 | ||
| 008 | 190411s1982 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0020307246 | |
| 024 | 7 | |2 cas |a 5 aminolevulinate synthase, 9037-14-3; chlordane, 12789-03-6, 57-74-9; dimethyl sulfoxide, 67-68-5; endosulfan, 115-29-7; heme, 14875-96-8; malathion, 121-75-5; parathion, 3270-86-8, 56-38-2, 597-88-6; porphyrin, 24869-67-8; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Chlordan, 12789-03-6; Dimethyl Sulfoxide, 67-68-5; Endosulfan, 115-29-7; Malathion, 121-75-5; Parathion, 56-38-2; Pesticides; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a TXCYA | ||
| 100 | 1 | |a Del C. Vila, M. | |
| 245 | 1 | 0 | |a Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and alasynthetase in chick embryo liver |
| 260 | |c 1982 | ||
| 270 | 1 | 0 | |m San Martín de Viale, L.C. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Granick, (1966) J. Biol. Chem., 241, p. 1359 | ||
| 504 | |a Marks, (1969) Heme and Chlorophyll. Chemical, Biochemical and Medical Aspects, p. 163. , D. Van Nostrand Company Ltd, London, Chapter 6 | ||
| 504 | |a Meyer, Schmid, The porphyrias (1978) Metabolic Basis of Inherited Diseases, p. 1164. , J.B. Stanbury et al., Mc Graw-Hill, New York | ||
| 504 | |a Smith, De Matteis, (1980) Clin. Haematol., 9, p. 399 | ||
| 504 | |a Vos, Strik, Van Holsteijn, Pennings, (1971) Toxicol. Appl. Pharmacol., 20, p. 232 | ||
| 504 | |a Goldstein, Hickman, Jue, (1974) Toxicol. Appl. Pharmacol., 27, p. 437 | ||
| 504 | |a Goldstein, Hickman, Bergman, Vos, (1973) Res. Commun. Chem. Pathol. Pharmacol., 6, p. 919 | ||
| 504 | |a Poland, Glover, (1973) Science, 179, p. 476 | ||
| 504 | |a Koriba, Keeler, Park, Gehring, (1976) Toxicol. Appl. Pharmacol., 35, p. 553 | ||
| 504 | |a De Matteis, (1971) S.A. Med. J., 17, p. 126. , (Special Issue) | ||
| 504 | |a Taira, San Martín de Viale, (1980) Int. J. Biochem., 12, p. 1033 | ||
| 504 | |a Goldstein, Friesen, Linder, Hickman, Hass, Bergman, (1977) Biochem. Pharmacol., 26, p. 1549 | ||
| 504 | |a Wainstock de Calmanovici, San Martín de Viale, (1980) Int. J. Biochem., 12, p. 1039 | ||
| 504 | |a De Matteis, Prior, Rimington, (1961) Nature (Lond.), 191, p. 363 | ||
| 504 | |a San Martín de Viale, Nacht, Grinstein, (1970) Clin. Chim. Acta, 28, p. 13 | ||
| 504 | |a San Martín de Viale, Tomio, Ferramola, Sancovich, Tigier, Experimental porphyria induced in rats by hexachlorobenzene. Studies on enzymes associated with haem pathway. Effect of 17ß-Oestradiol (1976) Porphyrins in Human Diseases, p. 453. , M. Doss, Karger, Basel | ||
| 504 | |a San Martín de Viale, del C. Ríos de Molina, Wainstock de Calmanovici, Tomio, (1977) Biochem. J., 168, p. 393 | ||
| 504 | |a Elder, Evans, Martin, (1976) Clin. Sci. Mol. Med., 51, p. 71 | ||
| 504 | |a Debets, Reinders, Debets, Lonbroek, Strik, (1981) Toxicology, 19, p. 185 | ||
| 504 | |a Koeman, Debets, Strik, The porphyrinogenic potential of pesticides with special emphasis on organophosphorous compounds (1980) Field Worker Exposure During Pesticide Application, 7, p. 157. , W.F. Tordoir, E.A.H. Van Heemstra-Lequin, Studies in Environmental Science, Elsevier/North-Holland | ||
| 504 | |a Granick, Kappas, (1967) J. Biol. Chem., 242, p. 4587 | ||
| 504 | |a Racz, Marks, (1969) Biochem. Pharmacol., 18, p. 2009 | ||
| 504 | |a Rifkind, Gillette, Song, Kappas, (1973) J. Pharmacol. Exp. Ther., 185, p. 214 | ||
| 504 | |a Marver, Tschudy, Perlroth, Collins, (1966) J. Biol. Chem., 241, p. 2803 | ||
| 504 | |a Sokal, Rohlf, (1969) The Principles and Practice of statistics in Biological Research, p. 124. , W.H. Freeman and Company, San Francisco | ||
| 504 | |a Sokal, Rohlf, (1969) Biometry. The Principles and Practice of Statistics in Biological Research, p. 392. , W.H. Freeman and Company, San Francisco | ||
| 504 | |a Doss, (1970) Z. Klin. Chem. Klin. Biochem., 8, p. 197 | ||
| 520 | 3 | |a In the present study we investigated the porphyrinogenic ability of 4 pesticides: chlordane, endosulfan, parathion and malathion, all of which are widely used in agriculture. In order to determine whether they affect the heme biosynthetic pathway we studied, in 17-day old chick embryo liver "in ovo", their effects on the amount of porphyrins and on the activity of δ-ALA synthetase (ALA-S), the first and rate limiting enzyme of this pathway. All of them induced hepatic porphyrin accumulation to a different extent compared with dimethylsulfoxide (DMSO) controls. Parathion as well as endosulfan promoted remarkable increases, chlordane raised porphyrin level in a lower degree and malathion slightly modified it. However, the accumulation observed with malathion was markedly enhanced if the period of incubation was extended to 48 h and, even more, if a second dose was injected during these 48 h. When ALA-S activity was analyzed in the chick embryos treated with parathion or endosulfan no alteration could be found in spite of producing noticeable accumulation of porphyrins. In contrast, chlordane promoted a statistically significant elevation of ALA-S as well as malathion which produced the highest induction observed. These results show that not only organochlorinated but also organophosphorous pesticides affect heme metabolism and that induction of ALA-S and porphyrin accumulation are not parallel. © 1982. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: The authorsw ishto thankA na Silvia Haedof or her advicein the statistical evaluationo f the results.L .C. San Martin de Viale is a membero f the Careero f ScientificR esearcheirn the ConsejoN acionald e Investigaciones Cientfficasy Tdcnicas. (CONICET) BuenosA ires, ArgentinaM. . del C. Vfla thankst he CONICET for the award of a graduatefe llowshipP. art of this work was supportebdy grantsf romCONICET and from SUBCYT. | ||
| 593 | |a Laboratorio de Porfirinas, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a CHLORDANE |
| 690 | 1 | 0 | |a DIMETHYL SULFOXIDE |
| 690 | 1 | 0 | |a ENDOSULFAN |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a MALATHION |
| 690 | 1 | 0 | |a PARATHION |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a CHICKEN |
| 690 | 1 | 0 | |a EMBRYO |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a INTOXICATION |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a LIVER TOXICITY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHICK EMBRYO |
| 690 | 1 | 0 | |a CHLORDAN |
| 690 | 1 | 0 | |a DIMETHYL SULFOXIDE |
| 690 | 1 | 0 | |a ENDOSULFAN |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALATHION |
| 690 | 1 | 0 | |a PARATHION |
| 690 | 1 | 0 | |a PESTICIDES |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a San Martín de Viale, L.C. | |
| 773 | 0 | |d 1982 |g v. 25 |h pp. 323-332 |k n. 4 |p Toxicology |x 0300483X |w (AR-BaUEN)CENRE-7043 |t Toxicology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0300-483X(82)90110-X |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0300483X_v25_n4_p323_DelCVila |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0300483X_v25_n4_p323_DelCVila |y Registro en la Biblioteca Digital |
| 961 | |a paper_0300483X_v25_n4_p323_DelCVila |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 62181 | ||