Initiation, elongation and termination of polypeptide synthesis in cell-free systems from polyamine-deficient bacteria

Protein synthesis in a polyamine-auxotrophic mutant of E. coli cultivated in the absence and presence of putrescine has been studied. The ratio of in vivo polypeptide synthesis under both conditions was the same as that obtained with cell-free extracts derived from polyamine-depleted and supplemente...

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Autor principal: Algranati, I.D
Otros Autores: Goldemberg, S.H
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1981
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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LEADER 04961caa a22007937a 4500
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003 AR-BaUEN
005 20230518204224.0
008 190411s1981 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-0019784427 
024 7 |2 cas  |a putrescine, 110-60-1, 333-93-7; spermidine, 124-20-9, 334-50-9; spermine, 306-67-2, 71-44-3; Putrescine, 110-60-1; RNA, Transfer, Amino Acyl; tRNA, formylmethionine- 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a BBRCA 
100 1 |a Algranati, I.D. 
245 1 0 |a Initiation, elongation and termination of polypeptide synthesis in cell-free systems from polyamine-deficient bacteria 
260 |c 1981 
270 1 0 |m Algranati, I.D.; Instituto de Investigaciones Bioquímicas Fundación Campomar, Obligado 2490, 1428 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Lovgren, Pettersson, Loftfield, (1978) J. Biol. Chem, 253, pp. 6702-6710 
504 |a Takeda, Igarashi, (1969) Biochem. Biophys. Res. Commun, 37, pp. 917-924 
504 |a Algranati, Goldemberg, (1977) Biochem. Biophys. Res. Commun, 75, pp. 1045-1051 
504 |a Igarashi, Yabuki, Yoshioka, Eguchi, Hirose, (1977) Biochem. Biophys. Res. Commun, 75, pp. 163-171 
504 |a Atkins, Lewis, Anderson, Gesteland, (1975) J. Biol. Chem, 250, pp. 5688-5695 
504 |a Konecki, Kramer, Pinphanichakarn, Hardesty, (1975) Arch. Biochem. Biophys, 169, pp. 192-198 
504 |a Hunter, Farrell, Jackson, Hunt, (1977) Eur. J. Biochem, 75, pp. 149-157 
504 |a Jelenc, Kurland, (1979) Proc. Natl. Acad. Sci. U.S.A, 76, pp. 3174-3178 
504 |a Goldemberg, Algranati, Polyamine requirement for streptomycin action on protein synthesis in bacteria. (1981) Eur J Biochem, , (in press) 
504 |a Quigley, Teeter, Rich, (1978) Proc. Natl. Acad. Sci. U.S.A, 75, pp. 64-68 
504 |a Echandi, Algranati, (1975) Biochem. Biophys. Res. Commun, 62, pp. 313-319 
504 |a Echandi, Algranati, (1975) Biochem. Biophys. Res. Commun, 67, pp. 1185-1191 
504 |a Algranati, Goldemberg, (1977) Trends in Biochemical Sciences, 2, pp. 272-274 
504 |a Goldemberg, Algranati, (1977) Mol. Cell Biochem, 16, pp. 71-77 
504 |a Pestka, (1974) Methods Enzymol, 30, pp. 479-488 
504 |a Hobden, Cundliffe, (1978) Biochem. J, 170, pp. 57-61 
504 |a Darnbrough, Legon, Hunt, Jackson, (1973) J. Mol. Biol, 76, pp. 379-403 
504 |a Abraham, Olsnes, Pihl, (1979) FEBS Lett, 101, pp. 93-96 
520 3 |a Protein synthesis in a polyamine-auxotrophic mutant of E. coli cultivated in the absence and presence of putrescine has been studied. The ratio of in vivo polypeptide synthesis under both conditions was the same as that obtained with cell-free extracts derived from polyamine-depleted and supplemented bacteria. The markedly reduced activity in systems from polyamine starved cells is most probably due to a poorly efficient initiation step. The estimation of nascent peptide chains and their release from tRNA support the idea that polypeptide elongation and termination processes do not have decreased rates in systems from polyamine-depleted bacteria. © 1981.  |l eng 
593 |a Instituto de Investigaciones Bioquímicas Fundación Campomar, Obligado 2490, 1428 Buenos Aires, Argentina 
593 |a Facultad de Ciencias Exactas y Naturales, Obligado 2490, 1428 Buenos Aires, Argentina 
690 1 0 |a PUTRESCINE 
690 1 0 |a SPERMIDINE 
690 1 0 |a SPERMINE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a AUXOTROPHIC MUTANT 
690 1 0 |a ESCHERICHIA COLI 
690 1 0 |a HEREDITY 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a CELL-FREE SYSTEM 
690 1 0 |a ESCHERICHIA COLI 
690 1 0 |a KINETICS 
690 1 0 |a MUTATION 
690 1 0 |a PEPTIDE CHAIN ELONGATION 
690 1 0 |a PEPTIDE CHAIN INITIATION 
690 1 0 |a PEPTIDE CHAIN TERMINATION 
690 1 0 |a PUTRESCINE 
690 1 0 |a RIBOSOMES 
690 1 0 |a RNA, TRANSFER, AMINO ACYL 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
700 1 |a Goldemberg, S.H. 
773 0 |d 1981  |g v. 103  |h pp. 8-15  |k n. 1  |p Biochem. Biophys. Res. Commun.  |x 0006291X  |w (AR-BaUEN)CENRE-905  |t Biochemical and Biophysical Research Communications 
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856 4 0 |u https://doi.org/10.1016/0006-291X(81)91653-3  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_0006291X_v103_n1_p8_Algranati  |y Handle 
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