Ovarian Dysfunction in Streptozotocin-lnduced Diabetic Rats
The effect of streptozotocin diabetes on some ovarian functions in adult rats was examined. Diabetic diestrus animals showed reduced ovary weight and lower circulating levels of progesterone. Scatchard plots of binding data derived from ovarian paniculate fractions of normal and streptozotocin diabe...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1983
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 10009caa a22011297a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12171 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204222.0 | ||
| 008 | 190411s1983 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0020510323 | |
| 024 | 7 | |2 cas |a insulin, 9004-10-8; isophane insulin, 9004-17-5; progesterone, 57-83-0; streptozocin, 18883-66-4; Blood Glucose; Chorionic Gonadotropin; Cyclic AMP, 60-92-4; Insulin, 11061-68-0; Progesterone, 57-83-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Tesone, M. | |
| 245 | 1 | 0 | |a Ovarian Dysfunction in Streptozotocin-lnduced Diabetic Rats |
| 260 | |c 1983 | ||
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Rakieten, N., Rakieten, M.L., Nadkarni, M.V., Studies on the diabetogenic actions of streptozotocin (NSC 37919) (1963) Cancer Chemother Rep, 29, pp. 91-110 | ||
| 504 | |a Rerup, C.C., Drugs producing diabetes through damage of the insulin secretion cells (1970) Pharmacol Rev, 22, pp. 485-518 | ||
| 504 | |a Foglia, V.G., Rosner, J.M., Cattaneo de Peralta Ramos, M., Lema, B.E., Sexual disturbances in the male diabetic rat (1969) Horm Metab Res, 1, pp. 72-77 | ||
| 504 | |a Cattaneo de Peralta Ramos, M., Irusta, O., Foglia, V.G., Actiόn de las gonadotrofinas e insulina sobre la production de testosterona por testículos de ratas dia-beticas (1973) Rev Soc Argent Biol, 49, pp. 56-60 | ||
| 504 | |a Oksanen, A., Tuohimaa, P., Testicular lesions of streptozotocin diabetic rats (1975) Horm Res, 6, pp. 138-144 | ||
| 504 | |a Howland, B.E., Zebrowsky, E.H., Some effects of experimentally induced diabetes on pituitary-testicular relationships in rat (1976) Horm Metab Res, 8, pp. 465-469 | ||
| 504 | |a Charreau, E.H., Calvo, J.C., Tesone, M., Valle, L.B.S., Baranao, J.L.S., Insulin regulation of Leydig cell luteinizing hormone receptors (1978) J Biol Chem, 253, pp. 2504-2506 | ||
| 504 | |a Calvo, J.C., Valle, L.B.S., Barañao, J.L.S., Tesone, M., Charreau, E.H., NADPH generating enzymes in Leydig cells from diabetic rats (1979) Horm Metab Res, 11, pp. 161-164 | ||
| 504 | |a Tesone, M., Valle, L.B.S., Foglia, V.G., Charreau, E.H., Endocrine function of the testis in streptozotocin diabetic rats (1976) Acta Physiol Latinoamer, 26, pp. 387-394 | ||
| 504 | |a Tesone, M., Oliveira-Filho, R.M., Valle, L.B.S., Calvo, J.C., Barañao, J.L.S., Foglia, V.G., Charreau, E.H., Androgen receptors in the diabetic rat (1980) Diabetologia, 18, pp. 385-390 | ||
| 504 | |a Foglia, V.G., Trastomos sexuales de la rata diabética (1962) Acta Physiol Latinoamer, 12, pp. 22-35 | ||
| 504 | |a Foglia, V.G., Chieri, R.A., Cattaneo de Peralta Ramos, M., Mechanisms disturbances during pregnancy in the diabetic female rat (1970) Horm Metab Res, 2, pp. 76-80 | ||
| 504 | |a Conti, M., Harwood, J.P., Dufau, M.L., Catt, K.J., Effect of gonadotropin-induced receptor regulation on biological responses of isolated rat luteal cells (1977) J Biol Chem, 252, pp. 8869-8874 | ||
| 504 | |a Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin Phenol Reagent (1951) J Biol Chem, 193, pp. 265-275 | ||
| 504 | |a Brown, B.L., Albano, J.D.M., Ekins, R.P., Sgherzi, A.M., (1971) Biochem J, 121, pp. 561-562 | ||
| 504 | |a Thorell, J.I., Johansson, B.G., Enzymatic iodination of polypeptides with 125I to high specific activity (1971) Biochem Biophys Acta, 251, pp. 363-369 | ||
| 504 | |a Moyle, W.R., Netburn, M., Cosgrove, A.E., Krieger, J., Bahl, O.P., hCG-Leydig cell functional binding kinetics: Threshold and nonlinearity (1980) Amer J Physiol, 238, pp. E293-E305 | ||
| 504 | |a Scatchard, G., The attraction of proteins for small molecules and ions (1949) Ann NY Acad Sci, 51, pp. 660-672 | ||
| 504 | |a Li, C.C., Introduction for experimental statistics (1964), pp. 454-465. , New York, McGraw-Hill; Doerr, P., Hapten-radioimmunoassay of plasma oestradiol (1973) Acta Endocrinol, 72, pp. 330-344. , (Kbh) | ||
| 504 | |a Sala, G.B., Dufau, M.L., Catt, K.J., Gonadotropin action in isolated ovarian luteal cells. The intermediate role of adenosine 3’ 5’-monophosphate in hormonal stimulation of progesterone synthesis (1979) J Biol Chem, 254, pp. 2077-3083 | ||
| 504 | |a Dufau, M.L., Tsuruhara, T., Horner, K.A., Podestá, E., Catt, K.J., Intermediate role of adenosine 3’:5’-cyclic monophosphate and protein kinase during gonadotropin-induced steroidogenesis in testicular interstitial cells (1977) Proc Natl Acad Sci, 74, pp. 3419-3423. , USA | ||
| 504 | |a Liu, F.T.Y., Lin, H.S., Johnson, D.C., Serum FSH, LH and the ovarian response to exogenous gonadotropins in alloxan diabetic immature female rats (1972) Endocrinology, 91, pp. 1172-1179 | ||
| 504 | |a Kirchick, H.J., Keyes, P.L., Frye, B.E., Etiology of anovulation in the immature alloxan diabetic rat treated with PMSG: Absence of the preovulatory LH surge (1978) Endocrinology, 102, pp. 1867-1873 | ||
| 504 | |a Kirchick, H.J., Keyes, P.L., Frye, B.E., An explanation for anovulation in immature alloxan diabetic rats treated with PMSG: Reduced pituitary response to Gn-RH (1979) Endocrinology, 105, pp. 1343-1349 | ||
| 520 | 3 | |a The effect of streptozotocin diabetes on some ovarian functions in adult rats was examined. Diabetic diestrus animals showed reduced ovary weight and lower circulating levels of progesterone. Scatchard plots of binding data derived from ovarian paniculate fractions of normal and streptozotocin diabetic rats revealed the presence of one class of binding sites with high affinity for 125I-hCG. The apparent association constant of the hCG receptors of diabetic ovaries was comparable to that of normal gonads. However, a marked decrease (42%) in the number of hCG binding sites was found in diabetic animals. With isolated luteal cells similar results were obtained, and the administration of insulin to streptozotocin diabetic rats restored to normality the number of hCG binding sites. The maximal response of progesterone production by luteal cells from control ovaries was obtained with 10-10 M hCG. A 100-fold higher concentration of hCG was required for the maximum stimulation of cAMP synthesis. The cAMP response of cells from diabetic rats was significantly higher than that of control cells. However, luteal cells from diabetic rats showed some loss of sensitivity in the synthesis of progesterone during incubation with hCG. Most of the alterations seen in diabetic female rats could be restored with insulin therapy, indicating that insulin plays an important role in the regulation and maintenance of normal reproductive functions. It is suggested that the diminution of the LH receptor population causes the disruption of normal luteal cell function. This fact could be responsible for some of the reproductive alterations in the diabetic female rat. © 1983, SAGE Publications. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Tesone Marta 1 Ladenheim Ruth G. Oliveira-Filho Ricardo M. Chiauzzi Violeta A. Foglia Virgilio G. 1 Charreau Eduardo H. 1 Institute de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires Republica Argentina, and Departamento de Química Biologica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina 1 Established Investigators from the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina. 10 1983 174 1 123 130 | ||
| 593 | |a Institute de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires Republica Argentina, Departamento de Química Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN I 125 |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN RECEPTOR |
| 690 | 1 | 0 | |a CYCLIC AMP H 3 |
| 690 | 1 | 0 | |a GONADOTROPIN RECEPTOR |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a ISOPHANE INSULIN |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a PROGESTERONE H 3 |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a STREPTOZOCIN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CORPUS LUTEUM |
| 690 | 1 | 0 | |a DIESTRUS |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a ESTRUS |
| 690 | 1 | 0 | |a ETIOLOGY |
| 690 | 1 | 0 | |a FEMALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a INTRAVENOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARY INSUFFICIENCY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a STREPTOZOCIN DIABETES |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BINDING SITES |
| 690 | 1 | 0 | |a BLOOD GLUCOSE |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a CORPUS LUTEUM |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a DIABETES MELLITUS, EXPERIMENTAL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Ladenheim, R.G. | |
| 700 | 1 | |a Oliveira-Filho, R.M. | |
| 700 | 1 | |a Chiauzzi, V.A. | |
| 700 | 1 | |a Foglia, V.G. | |
| 700 | 1 | |a Charreau, E.H. | |
| 773 | 0 | |d 1983 |g v. 174 |h pp. 123-130 |k n. 1 |p Proc. Soc. Exp. Biol. Med. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Proceedings of the Society for Experimental Biology and Medicine | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020510323&doi=10.3181%2f00379727-174-41714&partnerID=40&md5=c0703399bd57fe84966342f26a0a17ca |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.3181/00379727-174-41714 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v174_n1_p123_Tesone |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v174_n1_p123_Tesone |y Registro en la Biblioteca Digital |
| 961 | |a paper_00379727_v174_n1_p123_Tesone |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 73124 | ||