Growth factors and hormones which affect survival, growth, and differentiation of the MCF-7 stem cells and their descendants
The human breast tumor cell line was separated by Percoll density gradient centrifugation into six different subpopulations, A to F, one of which (E) appears to contain the stem cells on the basis of several criteria (M. Resnicoff et al. 1987, Proc. Natl. Acad. Sci. USA84, 7295. We now analyzed the...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1989
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06331caa a22009617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11997 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204212.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024516933 | |
| 024 | 7 | |2 cas |a butyric acid, 107-92-6, 156-54-7, 461-55-2; estradiol, 50-28-2; insulin, 9004-10-8; prostaglandin F2 alpha, 551-11-1; thrombin, 9002-04-4; 13-cis-retinal, 472-86-6; Butyric Acid, 107-92-6; Butyric Acids; Culture Media; Dinoprost, 551-11-1; DNA, 9007-49-2; Estradiol, 50-28-2; Hormones; Insulin, 11061-68-0; Retinaldehyde, 116-31-4; Retinoids; Thrombin, EC 3.4.21.5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ECREA | ||
| 100 | 1 | |a Resnicoff, M. | |
| 245 | 1 | 0 | |a Growth factors and hormones which affect survival, growth, and differentiation of the MCF-7 stem cells and their descendants |
| 260 | |c 1989 | ||
| 270 | 1 | 0 | |m Medrano, E.E.; Instituto de Investigaciones Bioquimicas Fundacion Campomar, Facultad de Ciencias Exactas y Naturales (UBA), Patricias Argentinas 435, 1405 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Hepner, (1984) Cancer Res, 44, pp. 2259-2265 | ||
| 504 | |a Buick, Pollack, (1984) Cancer Res, 44, pp. 4909-4918 | ||
| 504 | |a Resnicoff, Medrano, Podhajcer, Bravo, Bover, Mordoh, (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 7295-7299 | ||
| 504 | |a Medrano, Cafferata, Larcher, (1987) Exp. Cell Res, 172, pp. 354-364 | ||
| 504 | |a Medrano, E. E., Resnicoff, M., Larcher, F., Cafferata, E. G. A., Podhajcer, O. L., Bover, L., and Molinari, submitted for publication; Resnicoff, Medrano, (1987) Biochem. Biophys. Res. Commun, 143, pp. 309-315 | ||
| 504 | |a Podhajcer, Resnicoff, Bover, Medrano, Slavutsky, Larripa, Mordoh, (1988) Exp Cell Res, , in press | ||
| 504 | |a Gomez, Medrano, Cafferata, Tellez-Inon, (1988) Exp. Cell Res, 175, pp. 74-80 | ||
| 504 | |a Raben, Yasuda, Cunningham, (1987) Journal of Cellular Physiology, 130, pp. 468-473 | ||
| 504 | |a L'Allemain, Paris, Magnaldo, Poyssegur, (1986) J. Cell. Physiol, 129, pp. 167-174 | ||
| 504 | |a Carney, Scott, Gordon, La Belle, (1985) Cell, 42, pp. 479-488 | ||
| 504 | |a Davis, Weakland, Weiland, Farese, West, (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 3728-3732 | ||
| 504 | |a Macphee, Drummond, Otto, Jimenez de Asua, (1984) J. Cell. Physiol, 119, pp. 35-40 | ||
| 504 | |a Dickson, Kasid, Huff, Bates, Knabbe, Bronzert, Gelmann, Lippman, (1987) Proc. Natl. Acad. Sci USA, 84, pp. 837-841 | ||
| 504 | |a Knabbe, Lippman, Wakefield, Flanders, Kasid, Derynck, Dickson, (1987) Cell, 48, pp. 417-428 | ||
| 504 | |a Abe, Kufe, (1986) J. Cell. Physiol, 126, pp. 126-132 | ||
| 520 | 3 | |a The human breast tumor cell line was separated by Percoll density gradient centrifugation into six different subpopulations, A to F, one of which (E) appears to contain the stem cells on the basis of several criteria (M. Resnicoff et al. 1987, Proc. Natl. Acad. Sci. USA84, 7295. We now analyzed the response of the isolated subpopulations to insulin, thrombin, PGF2a, estradiol, and 13-cis-retinal. We demonstrate that the first two growth factors stimulate [3H]thymidine incorporation in the more differentiated subpopulations (D and F), while PGF2a has mitogenic activity in subpopulations C and D. In the absence of any added growth factor, estradiol has the extreme and transient capacity of allowing the stem cell to detach from the tissue culture dish and to grow in suspension as multicellular aggregates (MCF-7/SE cells). 13-cis-Retinal acts as a negative modulator of differentiation and protects the cells from the inhibitory and differentiation activity of Na-butyrate. © 1989. |l eng | |
| 536 | |a Detalles de la financiación: Support for this work was from the Consejo National de Investigaciones Cientiftcas y Tecnicas de Argentina (CONICET), and from the Fundacion Maria Calderon de la Barca. E.E.M. is a Career Researcher of the CONICET and M.R. is a Fellow of the Fundacion Maria Calderon de la Barca. We thank E. G. A. Cafferata for excellent technical assistance. We are grateful to Dr Luis Jimenez de Asua for critically reading the manuscript and to Maria Dolores Turro for typing it. | ||
| 593 | |a Instituto de Investigaciones Bioquimicas Fundacion Campomar, Facultad de Ciencias Exactas y Naturales (UBA), Patricias Argentinas 435, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 13 CIS RETINAL |
| 690 | 1 | 0 | |a BUTYRIC ACID |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN F2 ALPHA |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a THROMBIN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL GROWTH |
| 690 | 1 | 0 | |a CELL STRAIN MCF 7 |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a BREAST NEOPLASMS |
| 690 | 1 | 0 | |a BUTYRIC ACID |
| 690 | 1 | 0 | |a BUTYRIC ACIDS |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CULTURE MEDIA |
| 690 | 1 | 0 | |a DINOPROST |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a HORMONES |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a RETINALDEHYDE |
| 690 | 1 | 0 | |a RETINOIDS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a THROMBIN |
| 690 | 1 | 0 | |a TUMOR CELLS, CULTURED |
| 690 | 1 | 0 | |a TUMOR STEM CELLS |
| 700 | 1 | |a Medrano, E.E. | |
| 773 | 0 | |d 1989 |g v. 181 |h pp. 116-125 |k n. 1 |p Exp. Cell Res. |x 00144827 |w (AR-BaUEN)CENRE-797 |t Experimental Cell Research | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024516933&doi=10.1016%2f0014-4827%2889%2990187-0&partnerID=40&md5=407aa4957dcf90cdef9e994d6221194c |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0014-4827(89)90187-0 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00144827_v181_n1_p116_Resnicoff |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144827_v181_n1_p116_Resnicoff |y Registro en la Biblioteca Digital |
| 961 | |a paper_00144827_v181_n1_p116_Resnicoff |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 72950 | ||