Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: Possible role of leptin
Placentas from gestational diabetes (GDM) suffer from structural and functional changes including overgrowth. That is why we aimed to study [ 3H]-leucine incorporation into protein in addition to translation signaling in placenta from GDM. Thus, we investigated the expression of leptin and leptin re...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 13894caa a22014057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11756 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204156.0 | ||
| 008 | 190411s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84878582344 | |
| 024 | 7 | |2 cas |a leucine, 61-90-5, 7005-03-0; Leptin; Receptors, Leptin | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a HMMRA | ||
| 100 | 1 | |a Pérez-Pérez, A. | |
| 245 | 1 | 0 | |a Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: Possible role of leptin |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Sánchez-Margalet, V.; Department Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, Av. Dr. Fedriani 3, Sevilla 41071, Spain; email: margalet@us.es |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Placentas from gestational diabetes (GDM) suffer from structural and functional changes including overgrowth. That is why we aimed to study [ 3H]-leucine incorporation into protein in addition to translation signaling in placenta from GDM. Thus, we investigated the expression of leptin and leptin receptor (LEPR), as well as the activation state of signaling proteins regulating protein synthesis, such as mTOR, S6 Kinase, EIF4E-BP1, EIF4E, and eEF2 by measuring protein phosphorylation by immunoblot. [ 3H]-Leucine incorporation into protein also was determined in trophoblastic placenta explants from GDM and control pregnancy. We found that leptin and LEPR expression are increased in placentas from GDM and the translation machinery activity as well as [3H]-leucine incorporation into protein were higher in placentas from GDM compared with placentas from control pregnancy. In conclusion, protein synthesis rate is increased in placenta from GDM patients, and this may be due, at least in part, by the activation of translation signaling. The increased expression of leptin and LEPR may contribute to these effects. These results may provide a possible mechanism for the previously observed increase in placenta growth in GDM. |l eng | |
| 593 | |a Departamento de Bioquímica Médica y Biología Molecular, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 593 | |a Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain | ||
| 690 | 1 | 0 | |a EIF4EBP1 |
| 690 | 1 | 0 | |a GESTATIONAL DIABETES |
| 690 | 1 | 0 | |a LEPR |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a MTOR |
| 690 | 1 | 0 | |a TRANSLATION |
| 690 | 1 | 0 | |a TROPHOBLASTIC CELLS |
| 690 | 1 | 0 | |a INITIATION FACTOR 4E |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LEPTIN RECEPTOR |
| 690 | 1 | 0 | |a LEUCINE |
| 690 | 1 | 0 | |a MAMMALIAN TARGET OF RAPAMYCIN |
| 690 | 1 | 0 | |a S6 KINASE |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTOR E2F1 |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a EXPLANT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOBLOTTING |
| 690 | 1 | 0 | |a PREGNANCY DIABETES MELLITUS |
| 690 | 1 | 0 | |a PREGNANT WOMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN PHOSPHORYLATION |
| 690 | 1 | 0 | |a PROTEIN SYNTHESIS |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a CASE-CONTROL STUDIES |
| 690 | 1 | 0 | |a DIABETES, GESTATIONAL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RECEPTORS, LEPTIN |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a YOUNG ADULT |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Maymó, J.L. | |
| 700 | 1 | |a Gambino, Y.P. | |
| 700 | 1 | |a Guadix, P. | |
| 700 | 1 | |a Dueñas, J.L. | |
| 700 | 1 | |a Varone, C.L. | |
| 700 | 1 | |a Sánchez-Margalet, V. | |
| 773 | 0 | |d 2013 |g v. 45 |h pp. 436-442 |k n. 6 |p Horm. Metab. Res. |x 00185043 |t Hormone and Metabolic Research | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00185043_v45_n6_p436_PerezPerez |y Handle |
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