Hsp90-binding immunophilins as a potential new platform for drug treatment

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Immunophilins are proteins that contain a PPIase domain as a family signature. Low-molecular-weight immunophilins were first described associated to immunosuppressive action and protein folding. Recent studies of other members of the family have led to the identification of their participation in ba...

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Autor principal: Erlejman, A.G
Otros Autores: Lagadari, M., Galigniana, M.D
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2013
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debio 025; fk 506
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84876132812 
024 7 |2 cas  |a alisporivir, 254435-95-5; cyclosporin A, 59865-13-3, 63798-73-2; rapamycin, 53123-88-9; tacrolimus, 104987-11-3; HSP90 Heat-Shock Proteins; Immunophilins, 5.2.1.8 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
100 1 |a Erlejman, A.G. 
245 1 0 |a Hsp90-binding immunophilins as a potential new platform for drug treatment 
260 |c 2013 
270 1 0 |m Galigniana, M.D.; Departamento de Química Biológica-IQUIBICEN, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (C1428EGA), Argentina; email: mgali@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Immunophilins are proteins that contain a PPIase domain as a family signature. Low-molecular-weight immunophilins were first described associated to immunosuppressive action and protein folding. Recent studies of other members of the family have led to the identification of their participation in basic processes such as protein-protein interactions, signal transduction cascades, cell differentiation, cell cycle progression, metabolic activity, apoptosis mechanisms, microorganisms infection, cancer, neurotrophism and neuroprotection, among several other physiological and pathophysiological processes. Due to all these emerging features, the development of specific ligands for immunophilins appears to have promising perspectives, in particular in the fields of cancer biology and neuroregeneration fields. We review the emerging role of immunophilins in protein transport, transcription regulation, malignancies development and neurotrophic action, in addition to a number of biological properties that transform these proteins in potential targets for novel therapeutic strategies. © 2013 Future Science Ltd.  |l eng 
593 |a Departamento de Química Biológica-IQUIBICEN, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (C1428EGA), Argentina 
593 |a Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires (C1428ADN), Buenos Aires, Argentina 
690 1 0 |a ALISPORIVIR 
690 1 0 |a APOLIPOPROTEIN E 
690 1 0 |a CORTICOSTEROID RECEPTOR 
690 1 0 |a CYCLIN D1 
690 1 0 |a CYCLOSPORIN A 
690 1 0 |a FK 506 BINDING PROTEIN 
690 1 0 |a GLUCOCORTICOID RECEPTOR 
690 1 0 |a HEAT SHOCK PROTEIN 90 
690 1 0 |a IMMUNOPHILIN 
690 1 0 |a RAPAMYCIN 
690 1 0 |a TACROLIMUS 
690 1 0 |a TRANSCRIPTION FACTOR YY1 
690 1 0 |a ALZHEIMER DISEASE 
690 1 0 |a AMINO ACID SEQUENCE 
690 1 0 |a APOPTOSIS 
690 1 0 |a BREAST CARCINOMA 
690 1 0 |a CELL ACTIVITY 
690 1 0 |a CELL CYCLE PROGRESSION 
690 1 0 |a CELL DIFFERENTIATION 
690 1 0 |a CELL METABOLISM 
690 1 0 |a CHROMATIN ASSEMBLY AND DISASSEMBLY 
690 1 0 |a CHROMATIN STRUCTURE 
690 1 0 |a COLORECTAL CARCINOMA 
690 1 0 |a GENETIC TRANSCRIPTION 
690 1 0 |a HEPATITIS C 
690 1 0 |a HUMAN 
690 1 0 |a IMMUNOREACTIVITY 
690 1 0 |a METASTATIC MELANOMA 
690 1 0 |a MOLECULAR WEIGHT 
690 1 0 |a NERVE CELL DIFFERENTIATION 
690 1 0 |a NEUROPROTECTION 
690 1 0 |a NEUROTROPISM 
690 1 0 |a NONHUMAN 
690 1 0 |a PATHOPHYSIOLOGY 
690 1 0 |a PHASE 3 CLINICAL TRIAL (TOPIC) 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROSTATE CARCINOMA 
690 1 0 |a PROTEIN FOLDING 
690 1 0 |a PROTEIN MOTIF 
690 1 0 |a PROTEIN PROTEIN INTERACTION 
690 1 0 |a PROTEIN TRANSPORT 
690 1 0 |a REVIEW 
690 1 0 |a SIGNAL TRANSDUCTION 
690 1 0 |a TETRATRICOPEPTIDE REPEAT 
690 1 0 |a TRANSCRIPTION INITIATION 
690 1 0 |a TRANSCRIPTION REGULATION 
690 1 0 |a ANIMALS 
690 1 0 |a DRUG DISCOVERY 
690 1 0 |a HSP90 HEAT-SHOCK PROTEINS 
690 1 0 |a HUMANS 
690 1 0 |a IMMUNOPHILINS 
690 1 0 |a NEOPLASMS 
690 1 0 |a NEUROGENESIS 
690 1 0 |a PROTEIN BINDING 
690 1 0 |a PROTEIN TRANSPORT 
690 1 0 |a TRANSCRIPTIONAL ACTIVATION 
653 0 0 |a debio 025; fk 506 
700 1 |a Lagadari, M. 
700 1 |a Galigniana, M.D. 
773 0 |d 2013  |g v. 5  |h pp. 591-607  |k n. 5  |p Future. Med. Chem.  |x 17568919  |t Future Medicinal Chemistry 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876132812&doi=10.4155%2ffmc.13.7&partnerID=40&md5=1411dbf669422e8dac5664bcc266042b  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.4155/fmc.13.7  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_17568919_v5_n5_p591_Erlejman  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17568919_v5_n5_p591_Erlejman  |y Registro en la Biblioteca Digital 
961 |a paper_17568919_v5_n5_p591_Erlejman  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 72597 

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