The use of alternative polyadenylation sites renders integrin β1 (Itgb1) mRNA isoforms with differential stability during mammary gland development
Integrins are heterodimeric cell-surface adhesion receptors that play a critical role in tissue development. Characterization of the full-length mRNA encoding the β1 subunit (Itgb1) revealed an alternative functional cleavage and polyadenylation site that yields a new Itgb1 mRNA isoform 578 bp short...
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2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 13608caa a22015617a 4500 | ||
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| 001 | PAPER-11311 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204126.0 | ||
| 008 | 190411s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84881503610 | |
| 024 | 7 | |2 cas |a caspase 3, 169592-56-7; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; Antigens, CD29; RNA Isoforms; RNA, Messenger; RNA, Small Interfering; Recombinant Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BIJOA | ||
| 100 | 1 | |a Naipauer, J. | |
| 245 | 1 | 4 | |a The use of alternative polyadenylation sites renders integrin β1 (Itgb1) mRNA isoforms with differential stability during mammary gland development |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Kordon, E.C.; Departamento de Fisiología y Biología Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEN-UBA), Buenos Aires C1428EHA, Argentina; email: ekordon@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Integrins are heterodimeric cell-surface adhesion receptors that play a critical role in tissue development. Characterization of the full-length mRNA encoding the β1 subunit (Itgb1) revealed an alternative functional cleavage and polyadenylation site that yields a new Itgb1 mRNA isoform 578 bp shorter than that previously reported. Using a variety of experimental and bioinformatic approaches, we found that the two Itgb1 isoforms are expressed at different levels in a variety of mouse tissues, including the mammary gland, where they are differentially regulated at successive developmental stages. The longer mRNA species is prevelant during lactation, whereas the shorter is induced after weaning. In 3D cultures, where expression of integrin β1 protein is required for normal formation of acini, experimental blockade of the longer isoform induced enhanced expression of the shorter species which allowed normal morphological mammary differentiation. The short isoform lacks AU-rich motifs and miRNA target sequences that are potentially implicated in the regulation of mRNA stability and translation efficiency. We further determined that the AU-binding protein HuR appears to selectively stabilize the longer isoform in the mammary gland. In summary, the results of the present study identify a newregulatory instance involved in the fine-tuning of Itgb1 expression during mammary gland development and function. © 2013 Biochemical Society. |l eng | |
| 593 | |a Departamento de Fisiología y Biología Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEN-UBA), Buenos Aires C1428EHA, Argentina | ||
| 593 | |a IFIBYNE-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina | ||
| 593 | |a CEFYBO-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina | ||
| 593 | |a DBMS, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada | ||
| 593 | |a Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, United States | ||
| 593 | |a CINIBA, Facultad de Ciencias Médicas, Universidad Nacional de la Plata (UNLP), Buenos Aires 1900, Argentina | ||
| 690 | 1 | 0 | |a ALTERNATIVE POLYADENYLATION |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a HUR |
| 690 | 1 | 0 | |a ITGB1 |
| 690 | 1 | 0 | |a MAMMARY GLAND |
| 690 | 1 | 0 | |a MRNA |
| 690 | 1 | 0 | |a BETA1 INTEGRIN |
| 690 | 1 | 0 | |a CASPASE 3 |
| 690 | 1 | 0 | |a DACTINOMYCIN |
| 690 | 1 | 0 | |a HUR PROTEIN |
| 690 | 1 | 0 | |a MICRORNA |
| 690 | 1 | 0 | |a RNA ISOFORM |
| 690 | 1 | 0 | |a SHORT HAIRPIN RNA |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST DEVELOPMENT |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CONSENSUS SEQUENCE |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a ELECTROPHORETIC MOBILITY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a POLYADENYLATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROMOTER REGION |
| 690 | 1 | 0 | |a PROTEIN BINDING |
| 690 | 1 | 0 | |a PROTEIN CLEAVAGE |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN STABILITY |
| 690 | 1 | 0 | |a RNA TRANSCRIPTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIGENS, CD29 |
| 690 | 1 | 0 | |a CELL CULTURE TECHNIQUES |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a DATA MINING |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, DEVELOPMENTAL |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MAMMARY GLANDS, ANIMAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a POLYADENYLATION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RECOMBINANT PROTEINS |
| 690 | 1 | 0 | |a RNA ISOFORMS |
| 690 | 1 | 0 | |a RNA PROCESSING, POST-TRANSCRIPTIONAL |
| 690 | 1 | 0 | |a RNA STABILITY |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a RNA, SMALL INTERFERING |
| 690 | 1 | 0 | |a SPECIFIC PATHOGEN-FREE ORGANISMS |
| 690 | 1 | 0 | |a WEANING |
| 700 | 1 | |a Gattelli, A. | |
| 700 | 1 | |a Degese, M.S. | |
| 700 | 1 | |a Slomiansky, V. | |
| 700 | 1 | |a Wertheimer, E. | |
| 700 | 1 | |a Lamarre, J. | |
| 700 | 1 | |a Castilla, L. | |
| 700 | 1 | |a Abba, M. | |
| 700 | 1 | |a Kordon, E.C. | |
| 700 | 1 | |a Coso, O.A. | |
| 773 | 0 | |d 2013 |g v. 454 |h pp. 345-357 |k n. 2 |p Biochem. J. |x 02646021 |w (AR-BaUEN)CENRE-205 |t Biochemical Journal | |
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| 856 | 4 | 0 | |u https://doi.org/10.1042/BJ20130062 |y DOI |
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