Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism
Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory responses, and immune abnormalities throughout life. Mice injected subcutaneous...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03423caa a22003737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11206 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204120.0 | ||
| 008 | 140217s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84885344926 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Lucchina, L. | |
| 245 | 1 | 0 | |a Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Depino, A.M.; Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA. Int. Guiraldes S/N, Ciudemail: adepino@conicet.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory responses, and immune abnormalities throughout life. Mice injected subcutaneously with 600mg/kg valproic acid (VPA600) at gestational day 12.5 show reduced social interaction in adulthood (at 8 weeks of age), and they have been proposed as a mouse model of autism. Here, we show that these adult animals present signs of chronic glial activation in the hippocampus and the cerebellum. Moreover, when they are challenged with a peripheral inflammatory stimulus (intraperitoneal lipopolysaccharides, LPS), VPA600 animals show an exacerbated inflammatory response. Two hours after LPS injection, VPA600 animals secrete more corticosterone to the blood than control mice, and show an increase in the levels of expression of proinflammatory cytokines in the spleen. After LPS challenge, VPA600 mice also show signs of increased neuroinflammation compared with control mice: they have more microglial cells in the hippocampus, and they show higher levels of proinflammatory cytokines in the cerebellum. Our results provide evidence of basal neuroinflammation and an altered inflammatory response in the VPA model of autism. We propose that this model can be used to evaluate the contribution of inflammatory reactivity to autism-related behaviors. These studies will contribute to elucidate the role of the inflammatory alterations observed in ASD individuals. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. |l eng | |
| 536 | |a Article in Press | ||
| 593 | |a Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Department of Physiology Molecular and Cellular Biology FCEyN University of Buenos Aires Buenos Aires Argentina | ||
| 690 | 1 | 0 | |a ASTROGLIA |
| 690 | 1 | 0 | |a BEHAVIOR |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HYPOTHALAMUS-PITUITARY-ADRENAL AXIS |
| 690 | 1 | 0 | |a MICROGLIA |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 700 | 1 | |a Depino, A.M. | |
| 773 | 0 | |d 2013 |p Autism Res. |x 19393792 |t Autism Research | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-84885344926&partnerID=40&md5=8028290e5e63762008c42e1f9a5e2c56 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1002/aur.1338 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_19393792_v_n_p_Lucchina |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19393792_v_n_p_Lucchina |y Registro en la Biblioteca Digital |
| 961 | |a paper_19393792_v_n_p_Lucchina |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 72159 | ||