Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies w...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03459caa a22004337a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11040 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204108.0 | ||
| 008 | 140217s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84890939314 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JRIMD | ||
| 100 | 1 | |a Sóñora, C. | |
| 245 | 1 | 0 | |a Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Sóñora, C.; Cátedra de Inmunología, Facultad de Ciencias/Facultad de Química, Universidad demail: csonora@fmed.edu.uy |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies were detected in a non-obese diabetic (NOD) mouse model of type I insulin-dependent diabetes mellitus and Sjögren's syndrome, two comorbid states with CD. Since pregnancy complications have been described in NOD mice, we evaluated the ability of anti-tTG antibodies to affect the functions of tTG relevant to the normal course of an early pregnancy like extracellular matrix assembling and apoptotic cell phagocytosis by macrophages. Circulating IgG antibodies against tTG were detected in NOD mice with titers that decreased at early pregnancy; interestingly, the in vitro transamidating activity of tTG was reduced by NOD serum samples. Particularly, anti-tTG antibody inhibited apoptotic cell phagocytosis by peritoneal macrophages from pregnant NOD mice that express the enzyme on surface. Evidence provided support for a role for anti-tTG antibodies through reduced transamidating activity and reduced apoptotic cell clearance by the macrophages of pregnant NOD mice. © 2013 Elsevier Ireland Ltd. All rights reserved. |l eng | |
| 536 | |a Article in Press | ||
| 593 | |a Cátedra de Inmunología, Facultad de Ciencias/Facultad de Química, Universidad de la República, Montevideo, Uruguay | ||
| 593 | |a Escuela Universitaria de Tecnología Médica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay | ||
| 593 | |a Laboratorio de Inmunofarmacología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES |
| 690 | 1 | 0 | |a CELIAC DISEASE |
| 690 | 1 | 0 | |a NOD MICE |
| 700 | 1 | |a Mourglia-Ettlin, G. | |
| 700 | 1 | |a Calo, G. | |
| 700 | 1 | |a Hauk, V. | |
| 700 | 1 | |a Ramhorst, R. | |
| 700 | 1 | |a Hernández, A. | |
| 700 | 1 | |a Leirós, C.P. | |
| 773 | 0 | |d 2013 |p J. Reprod. Immunol. |x 01650378 |t Journal of Reproductive Immunology | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-84890939314&partnerID=40&md5=40d29befa186c41a6be29f70d6db5a14 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jri.2013.11.001 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01650378_v_n_p_Sonora |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01650378_v_n_p_Sonora |y Registro en la Biblioteca Digital |
| 961 | |a paper_01650378_v_n_p_Sonora |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 71993 | ||