Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2
The limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) isolated from leaf extracts of Melia azedarach L, has potent antiherpetic effect in epithelial cells. Since Meliacine, the partially purified extract source of CDM, has therapeutic effect on murine genital herpes, the potential use of CDM as m...
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2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12347caa a22014417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11033 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204108.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84892437030 | |
| 024 | 7 | |2 cas |a 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide, 298-93-1; acridine orange, 494-38-2, 65-61-2; gamma interferon, 82115-62-6; nitric oxide, 10102-43-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PHYRE | ||
| 100 | 1 | |a Petrera, E. | |
| 245 | 1 | 0 | |a Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2 |
| 260 | |c 2014 | ||
| 270 | 1 | 0 | |m Petrera, E.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 4, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina; email: epetrera@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Alche, L.E., Barquero, A.A., San Juan, N.A., Coto, C.E., An antiviral principle present in a purified fraction from Melia azedarach L. Leaf aqueous extract restrains herpes simplex virus type 1 propagation (2002) Phytother Res, 16 (4), pp. 348-352 | ||
| 504 | |a Alche, L.E., Berra, A., Veloso, M.J., Coto, C.E., Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice (2000) J Med Virol, 61 (4), pp. 474-480 | ||
| 504 | |a Alche, L.E., Ferek, G.A., Meo, M., Coto, C.E., Maier, M.S., An antiviral meliacarpin from leaves of Melia azedarach L (2003) Z Naturforsch C, 58 (34), pp. 215-219 | ||
| 504 | |a Andrei, G.M., Damonte, E.B., De Torres, R.A., Coto, C.E., Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L (1988) Antiviral Res, 9 (4), pp. 221-231 | ||
| 504 | |a Andrei, G., Couto, A.S., De Lederkremer, R.M., Coto, C.E., Purification and partial characterization of an antiviral active peptide from Melia azedarach L (1994) Antiviral Chem Chemother, 5 (2), pp. 105-110 | ||
| 504 | |a Barquero, A.A., Alche, L.E., Coto, C.E., Antiviral activity of meliacine on the replication of a thymidine kinase-deficient mutant of herpes simplex virus type 1 (1997) Int J Antimicrob Agents, 9 (1), pp. 49-55 | ||
| 504 | |a Barquero, A.A., Alche, L.E., Coto, C.E., Block of vesicular stomatitis virus endocytic and exocytic pathways by 1-cinnamoyl-3,11-dihydroxymeliacarpin, a tetranortriterpenoid of natural origin (2004) J Gen Virol, 85 (PART 2), pp. 483-493 | ||
| 504 | |a Barquero, A.A., Michelini, F.M., Alche, L.E., 1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-kappaB modulating properties (2006) Biochem Biophys Res Commun, 344 (3), pp. 955-962 | ||
| 504 | |a Baskin, H., Ellermann-Eriksen, S., Lovmand, J., Mogensen, S.C., Herpes simplex virus type 2 synergizes with interferon-gamma in the induction of nitric oxide production in mouse macrophages through autocrine secretion of tumour necrosis factor-alpha (1997) J Gen Virol, 78 (PART 1), pp. 195-203 | ||
| 504 | |a Castilla, V., Barquero, A.A., Mersich, S.E., Coto, C.E., In vitro anti-Junin virus activity of a peptide isolated from Melia azedarach L. Leaves (1998) Int J Antimicrob Agents, 10 (1), pp. 67-75 | ||
| 504 | |a Catalone, B.J., Kish-Catalone, T.M., Budgeon, L.R., Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides (2004) Antimicrob Agents Chemother, 48 (5), pp. 1837-1847 | ||
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| 504 | |a Ding, A.H., Nathan, C.F., Stuehr, D.J., Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production (1988) J Immunol, 141 (7), pp. 2407-2412 | ||
| 504 | |a Elias, C.J., Coggins, C., Female-controlled methods to prevent sexual transmission of HIV (1996) AIDS, 10 (SUPPL.), pp. S43-S51 | ||
| 504 | |a Ellermann-Eriksen, S., Macrophages and cytokines in the early defence against herpes simplex virus (2005) Virol J, 2, p. 59 | ||
| 504 | |a Herbst-Kralovetz, M., Pyles, R., Toll-like receptors, innate immunity and HSV pathogenesis (2006) Herpes, 13 (2), pp. 37-41 | ||
| 504 | |a Herold, B.C., Siston, A., Bremer, J., Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens (1997) Antimicrob Agents Chemother, 41 (12), pp. 2776-2780 | ||
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| 504 | |a Hong, J., Nakano, Y., Yokomakura, A., Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells (2006) J Pharmacol Exp Ther, 319 (2), pp. 672-681 | ||
| 504 | |a Maguire, R.A., Bergman, N., Phillips, D.M., Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization (2001) Sex Transm Dis, 28 (5), pp. 259-265 | ||
| 504 | |a Milligan, G.N., Bernstein, D.I., Bourne, N., T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2 (1998) J Immunol, 160 (12), pp. 6093-6100 | ||
| 504 | |a Moncada, S., Palmer, R.M., Inhibition of the induction of nitric oxide synthase by glucocorticoids: Yet another explanation for their anti-inflammatory effects? (1991) Trends Pharmacol Sci, 12 (4), pp. 130-131 | ||
| 504 | |a Paludan, S.R., Synergistic action of pro-inflammatory agents: Cellular and molecular aspects (2000) J Leukoc Biol, 67 (1), pp. 18-25 | ||
| 504 | |a Petrera, E., Coto, C.E., Effect of meliacine, a plant derived antiviral, on tumor necrosis factor alpha (2003) Fitoterapia, 74 (12), pp. 77-83 | ||
| 504 | |a Petrera, E., Coto, C.E., The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin (2006) Virol J, 3, p. 45 | ||
| 504 | |a Petrera, E., Coto, C.E., Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection (2009) Phytother Res, 23 (12), pp. 1771-1777 | ||
| 504 | |a Shimeld, C., Whiteland, J.L., Williams, N.A., Easty, D.L., Hill, T.J., Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1 (1997) J Gen Virol, 78 (PART 12), pp. 3317-3325 | ||
| 504 | |a Sit, M.F., Tenney, D.J., Rothstein, J.L., Morahan, P.S., Effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2 (1988) J Gen Virol, 69 (PART 8), pp. 1999-2010 | ||
| 504 | |a Unanue, E.R., The regulatory role of macrophages in antigenic stimulation. Part Two: Symbiotic relationship between lymphocytes and macrophages (1981) Adv Immunol, 31, pp. 1-136 | ||
| 504 | |a Wachsman, M.B., Damonte, E.B., Coto, C.E., De Torres, R.A., Antiviral effects of Melia azedarach L. Leaves extracts on Sindbis virus-infected cells (1987) Antiviral Res, 8 (1), pp. 1-12 | ||
| 504 | |a Wachsman, M.B., Castilla, V., Coto, C.E., Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L leaves (1998) Arch Virol, 143 (3), pp. 581-590 | ||
| 504 | |a Yun, H.Y., Dawson, V.L., Neurobiology of nitric oxide (1996) Crit Rev Neurobiol, 10 (34), pp. 291-316 | ||
| 520 | 3 | |a The limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) isolated from leaf extracts of Melia azedarach L, has potent antiherpetic effect in epithelial cells. Since Meliacine, the partially purified extract source of CDM, has therapeutic effect on murine genital herpes, the potential use of CDM as microbicide against herpetic infections was studied here. To determine the cytotoxic effect of CDM, the MTT assay and acridine orange staining of living cells were performed. The antiherpetic action of CDM was measured by plaque reduction assay, and the immunomodulatory effect was determined by measuring the cytokine production using a bioassay and ELISA method. The results presented here showed that CDM inhibited Herpes Simplex Virus type 2 (HSV-2) multiplication in Vero cells but did not affect its replication in macrophages which were not permissive to HSV infection. In macrophages, levels of TNF-α, IFN-γ, NO, IL-6 and IL-10 were increased by CDM used alone or in combination with HSV-2. Besides, CDM not only synergized TNF-α production combined with IFN-γ, but also prolonged its expression in time. Results indicate that CDM inhibits HSV-2 multiplication in epithelial cells and also increases cytokine production in macrophages, both important actions to the clearance of infecting virus in the mouse vagina. Copyright © 2013 John Wiley & Sons, Ltd. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 4, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HSV-2 |
| 690 | 1 | 0 | |a IMMUNOMODULATOR |
| 690 | 1 | 0 | |a TETRANORTRITERPENOID |
| 690 | 1 | 0 | |a 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE |
| 690 | 1 | 0 | |a ACRIDINE ORANGE |
| 690 | 1 | 0 | |a ANTIVIRUS AGENT |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a GAMMA INTERFERON |
| 690 | 1 | 0 | |a INTERLEUKIN 10 |
| 690 | 1 | 0 | |a INTERLEUKIN 6 |
| 690 | 1 | 0 | |a LIMONOID 1 CINNAMOYL 3,11 DIHYDROXYMELIACARPIN |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR ALPHA |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a CYTOTOXICITY TEST |
| 690 | 1 | 0 | |a DRUG DETERMINATION |
| 690 | 1 | 0 | |a DRUG POTENCY |
| 690 | 1 | 0 | |a ENZYME LINKED IMMUNOSORBENT ASSAY |
| 690 | 1 | 0 | |a EPITHELIUM CELL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 2 |
| 690 | 1 | 0 | |a MACROPHAGE ACTIVATION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PLANT LEAF |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a VERO CELL |
| 690 | 1 | 0 | |a VIRUS INHIBITION |
| 690 | 1 | 0 | |a VIRUS PLAQUE |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a HERPES |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 2 |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a MURINAE |
| 690 | 1 | 0 | |a SIMPLEXVIRUS |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HSV-2 |
| 690 | 1 | 0 | |a IMMUNOMODULATOR |
| 690 | 1 | 0 | |a TETRANORTRITERPENOID |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HERPESVIRUS 2, HUMAN |
| 690 | 1 | 0 | |a INHIBITORY CONCENTRATION 50 |
| 690 | 1 | 0 | |a INTERFERON-GAMMA |
| 690 | 1 | 0 | |a INTERLEUKIN-10 |
| 690 | 1 | 0 | |a INTERLEUKIN-6 |
| 690 | 1 | 0 | |a LIMONINS |
| 690 | 1 | 0 | |a MACROPHAGES |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a NITRIC OXIDE |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR-ALPHA |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 700 | 1 | |a Coto, C.E. | |
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