CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccin...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2014
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03058caa a22004457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-10962 | ||
| 003 | AR-BaUEN | ||
| 005 | 20240415150254.0 | ||
| 008 | 140217s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84893183412 | |
| 030 | |a VACCD | ||
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Ruiz, M.S. | |
| 245 | 1 | 0 | |a CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice |
| 260 | |c 2014 | ||
| 270 | 1 | 0 | |m Gazzaniga, S.; Dpto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Bemail: sgazza@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Article in Press | ||
| 593 | |a Dpto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Fundación Instituto Leloir, IIBBA CONICET, Buenos Aires, Argentina | ||
| 593 | |a Hospital Eva Perón, San Martín, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CD207+ CELLS |
| 690 | 1 | 0 | |a DENDRITIC CELLS |
| 690 | 1 | 0 | |a ECTOPIC LYMPHOID TISSUE |
| 690 | 1 | 0 | |a MELANOMA |
| 690 | 1 | 0 | |a VACCINE |
| 700 | 1 | |a Mac Keon, S. | |
| 700 | 1 | |a Campisano, S. | |
| 700 | 1 | |a Bravo, A.I. | |
| 700 | 1 | |a Gazzaniga, S. | |
| 700 | 1 | |a Wainstok, Rosa | |
| 773 | 0 | |d 2014 |p Vaccine |x 0264410X |w (AR-BaUEN)CENRE-7118 |t Vaccine | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-84893183412&partnerID=40&md5=3b30e5eb8be014bcfbc8423a2ebc16cc |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.vaccine.2014.01.025 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0264410X_v_n_p_Ruiz |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0264410X_v_n_p_Ruiz |y Registro en la Biblioteca Digital |
| 961 | |a paper_0264410X_v_n_p_Ruiz |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 71915 | ||