Inositolphosphoceramide metabolism in Trypanosoma cruzi as compared with other trypanosomatids
Chagas disease is caused by Trypanosoma cruzi and is endemic to North, Central and South American countries. Current therapy against this disease is only partially effective and produces adverse side effects. Studies on the metabolic pathways of T. cruzi, in particular those with no equivalent in ma...
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2011
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| LEADER | 21197caa a22016097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-10787 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131857.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-79952786037 | |
| 024 | 7 | |2 cas |a Ceramides; Glycosphingolipids; Protozoan Proteins; inositolphosphoceramides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JEMIE | ||
| 100 | 1 | |a De Lederkremer, R.M. | |
| 245 | 1 | 0 | |a Inositolphosphoceramide metabolism in Trypanosoma cruzi as compared with other trypanosomatids |
| 260 | |c 2011 | ||
| 270 | 1 | 0 | |m De Lederkremer, R. M.; CHIDECAR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina; email: lederk@quimor.qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Chagas disease is caused by Trypanosoma cruzi and is endemic to North, Central and South American countries. Current therapy against this disease is only partially effective and produces adverse side effects. Studies on the metabolic pathways of T. cruzi, in particular those with no equivalent in mammalian cells, might identify targets for the development of new drugs. Ceramide is metabolized to inositolphosphoceramide (IPC) in T. cruzi and other kinetoplastid protists whereas in mammals it is mainly incorporated into sphingomyelin. In T. cruzi, in contrast to Trypanosoma brucei and Leishmania spp., IPC functions as lipid anchor constituent of glycoproteins and free glycosylinositolphospholipids (GIPLs). Inhibition of IPC and GIPLs biosynthesis impairs differentiation of trypomastigotes into the intracellular amastigote forms. The gene encoding IPC synthase in T. cruzi has been identified and the enzyme has been expressed in a cell-free system. The enzyme involved in IPC degradation and the remodelases responsible for the incorporation of ceramide into free GIPLs or into the glycosylphosphatidylinositols anchoring glycoproteins, and in fatty acid modifications of these molecules of T. cruzi have been understudied. Inositolphosphoceramide metabolism and remodeling could be exploited as targets for Chagas disease chemotherapy. © 2011 The Author(s). |l eng | |
| 593 | |a CHIDECAR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina | ||
| 593 | |a Department of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, United States | ||
| 690 | 1 | 0 | |a GLYCOSYLINOSITOLPHOSPHOLIPIDS |
| 690 | 1 | 0 | |a GLYCOSYLPHOSPHATIDYLINOSITOL |
| 690 | 1 | 0 | |a INOSITOLPHOSPHOCERAMIDE |
| 690 | 1 | 0 | |a PHOSPHOLIPASE C |
| 690 | 1 | 0 | |a SPHINGOLIPIDS |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a CERAMIDE |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPID |
| 690 | 1 | 0 | |a INOSITOLPHOSPHOCERAMIDES |
| 690 | 1 | 0 | |a PROTOZOAL PROTEIN |
| 690 | 1 | 0 | |a CELL ORGANELLE |
| 690 | 1 | 0 | |a DRUG |
| 690 | 1 | 0 | |a ENDEMIC SPECIES |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a FATTY ACID |
| 690 | 1 | 0 | |a INHIBITION |
| 690 | 1 | 0 | |a LIPID |
| 690 | 1 | 0 | |a MAMMAL |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MOLECULAR ANALYSIS |
| 690 | 1 | 0 | |a PARASITIC DISEASE |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a PROTOZOAN |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a KINETOPLASTIDA |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a BIOSYNTHETIC PATHWAYS |
| 690 | 1 | 0 | |a CERAMIDES |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPIDS |
| 690 | 1 | 0 | |a PROTOZOAN PROTEINS |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATINA |
| 690 | 1 | 0 | |a KINETOPLASTIDA |
| 690 | 1 | 0 | |a MAMMALIA |
| 690 | 1 | 0 | |a PROTISTA |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA BRUCEI |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATIDAE |
| 700 | 1 | |a Agusti, R. | |
| 700 | 1 | |a Docampo, R. | |
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