Eighteen-deoxyaldosterone and other less polar forms of 18-hydroxycorticosterone as aldosterone precursors in rat adrenals
Samples containing as precursors either 18-hydroxycorticosterone (18-OH-B) in its M form, or this converted to less polar forms at pH 2 (ACM), or M or ACM enclosed in liposomes from adrenal lipids were incubated at pH 7.4, 4.8 or 3.3 in the presence or absence of quartered rat adrenals for 1 and 2 h...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1985
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08824caa a22009857a 4500 | ||
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| 001 | PAPER-1071 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203026.0 | ||
| 008 | 190411s1985 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021791251 | |
| 024 | 7 | |2 cas |a 18 deoxyaldosterone, 2507-88-2; 18 hydroxycorticosterone, 561-65-9; aldosterone, 52-39-1, 6251-69-0; 18-Hydroxycorticosterone, 561-65-9; 18-deoxyaldosterone, 2507-88-2; Aldosterone, 52-39-1; Corticosterone, 50-22-6; Liposomes | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSTBB | ||
| 100 | 1 | |a Cozza, E.N. | |
| 245 | 1 | 0 | |a Eighteen-deoxyaldosterone and other less polar forms of 18-hydroxycorticosterone as aldosterone precursors in rat adrenals |
| 260 | |c 1985 | ||
| 270 | 1 | 0 | |m Cozza, E.N.; PRHOM and UMYMFOR (CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Dominguez, The presence of two interconvertible forms of 18-hydroxy-11-deoxycorticosterone (1965) Steroids, pp. 29-49 | ||
| 504 | |a Aragonés, Gros, Lantos, Locascio, Less polar forms and derivatives of 18-hydroxycorticosterone (1978) J. steroid Biochem., 9, pp. 175-180 | ||
| 504 | |a Fraser, Lantos, 18-Hydroxycorticosterone: a review (1978) J. steroid Biochem., 9, pp. 273-286 | ||
| 504 | |a Raman, Sharma, Dorfman, Gabrilove, Biosynthesis of C-18-oxygenated steroids by an aldosterone-secreting human adrenal tumor. Metabolism of (4-14C) progesterone, (1,2-3H) 11-deoxycorticosterone and (4-14C) pregnenolone (1965) Biochemistry, 4, pp. 1376-1385 | ||
| 504 | |a Sandor, Lanthier, The biosynthesis in vitro of radioactive corticosteroids from (4-14C)progesterone by adrenal slices of the domestic duck (Anas platyr-hynchos) (1963) Biochim. biophys. Acta, 74, pp. 756-762 | ||
| 504 | |a Fattah, Whitehouse, Vinson, Biosynthesis of aldosterone from 18-hydroxylated precursors by rat adrenal tissue in vitro (1977) J. Endocr., 75, pp. 187-195 | ||
| 504 | |a Damasco, Lantos, The existence of two inconvertible forms of 18-hydroxycorticosterone: is one of them the active precursor of aldosterone? (1975) J. steroid Biochem., 6, pp. 69-74 | ||
| 504 | |a Aragonés, Lantos, Locascio, Spontaneous conversions to aldosterone (1976) Acta Physiol Lat Am, 26, pp. 277-282 | ||
| 504 | |a Ulick, Normal and alternate pathways in aldosterone biosynthesis (1973) Proc. Fourth Int. Congr. Endocrinol., p. 761. , Robert O. Scow, American Elsevier, New York | ||
| 504 | |a Bush, Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues (1952) Biochem. J., 50, pp. 370-378 | ||
| 504 | |a Abramson, Katzmann, Gregor, Aqueous dispersions of phosphatidylserine (1964) J. biol. Chem., 239, pp. 70-76 | ||
| 504 | |a Saunders, Perrin, Gammack, Ultrasonic irradiation of some phospholipid sols (1962) J. pharm. Pharmac., 14, pp. 567-572 | ||
| 504 | |a Kliman, Peterson, Double isotope derivative assay of aldosterone in biological extracts (1960) J biol. Chem., 235, pp. 1639-1648 | ||
| 504 | |a Cozza E. N., Lantos C. P. and Burton G.: A highly lipophylic form of aldosterone. Isolation and characterization of an aldosterone dimer. (Unpublished data); Harnik, Aharonowitz, Lamed, 18-deoxyaldosterone, its chemical and microbial reduction products (1982) Tetrahedron, 38, pp. 3189-3192 | ||
| 504 | |a Vecsei, Lommer, Wolff, The intermediate role of 18-hydroxycorticosteroids in aldosterone biosynthesis (1968) Experientia, 24, pp. 1199-1201 | ||
| 504 | |a Kojima, Inano, Tamaoki, The final step of aldosterone biosynthesis is catalized by an NADPH-dependent and molecular oxygen-requiring enzyme (1982) Biochem. biophys. Res. Commun., 106, pp. 617-624 | ||
| 504 | |a Reijngoud, Tager, The permeability properties of the lysosomal membrane (1977) Biochim. biophys. Acta, 472, pp. 419-449 | ||
| 504 | |a Xie, Stone, Racker, Determinants of clathrin-coated vesicle acidification (1983) J. biol. Chem., 258, pp. 14834-14838 | ||
| 504 | |a Mitchell, Moyle, Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria (1969) Eur. J. Biochem., 7, pp. 471-484 | ||
| 504 | |a Ulick, Gautier, Vetter, Markello, Yaffe, Lowe, An aldosterone biosynthetic defect in salt-losing disorder (1964) J. clin. Endocr. Metab., 24, pp. 669-672 | ||
| 504 | |a Finkelstein, Schaefer, Inborn errors of steroid biosynthesis (1979) Physiol. Rev., 59, pp. 353-406 | ||
| 504 | |a Marusic, White, Aedo, Oxidative reactions in the formation of an aldehyde group in the biosynthesis of aldosterone (1973) Archs biochem. Biophys., 157, pp. 320-321 | ||
| 504 | |a Aupetit, Accarie, Emeric, Vonrax, Legrand, The final step of aldosterone biosynthesis requires reducing power; it is not a dehydrogenation (1983) Biochim. biophys. Acta, 752, pp. 73-78 | ||
| 504 | |a Usa, Ganguly, Weinberger, M and L forms of 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone: factors influencing conversion, stability and inmunological properties (1979) J. steroid Biochem., 10, pp. 557-562 | ||
| 504 | |a Pasqualini, Conversion of tritiated-18-hydroxycorticosterone to aldosterone by slices of human cortico-adrenal gland and adrenal tumour (1964) Nature, 201, p. 501 | ||
| 504 | |a Müller, The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway (1980) J. steroid Biochem., 13, pp. 245-251 | ||
| 504 | |a Vinson, Whitehouse, The biosynthesis and secretion of aldosterone by the rat zona glomerulosa and the significance of the compartmental arrangement of steroids (1973) Acta endocr, Copenh., 72, pp. 52-76 | ||
| 520 | 3 | |a Samples containing as precursors either 18-hydroxycorticosterone (18-OH-B) in its M form, or this converted to less polar forms at pH 2 (ACM), or M or ACM enclosed in liposomes from adrenal lipids were incubated at pH 7.4, 4.8 or 3.3 in the presence or absence of quartered rat adrenals for 1 and 2 h. Optimal (10%) yields of aldosterone were obtained when (a) ACM was incubated at pH 4.8 and (b) M enclosed in liposomes was suspended in buffer and shaken without enzyme at pH 3.3. When conditions (a) were supplemented with malate and NADP, 16% of ACM was converted to aldosterone. ACM contained 80% of a fraction which, according to 13C NMR spectroscopy, was identical to 18-deoxyaldosterone (18-DAL). Experiments in which radioactivity from corticosterone (B) or M was trapped by radioinert M or 18-DAL disclosed a pathway comprising sequentially B, 18-OH-B, 18-DAL and aldosterone, and the combined evidence of this work, an enzymatic hydroxylation of 18-DAL to aldosterone. © 1985. |l eng | |
| 593 | |a PRHOM and UMYMFOR (CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina | ||
| 593 | |a Center for Biotechnology, the George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel | ||
| 593 | |a Department of Chemistry, Texas A and M University, College Station, TX 77843, United States | ||
| 690 | 1 | 0 | |a 18 DEOXYALDOSTERONE |
| 690 | 1 | 0 | |a 18 HYDROXYCORTICOSTERONE |
| 690 | 1 | 0 | |a ALDOSTERONE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ADRENAL GLAND |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a 18-HYDROXYCORTICOSTERONE |
| 690 | 1 | 0 | |a ADRENAL GLANDS |
| 690 | 1 | 0 | |a ALDOSTERONE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a HYDROGEN-ION CONCENTRATION |
| 690 | 1 | 0 | |a LIPOSOMES |
| 690 | 1 | 0 | |a MAGNETIC RESONANCE SPECTROSCOPY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Burton, G. | |
| 700 | 1 | |a Ceballos, N.R. | |
| 700 | 1 | |a Lantos, C.P. | |
| 700 | 1 | |a Harnik, M. | |
| 700 | 1 | |a Scott, A.I. | |
| 773 | 0 | |d 1985 |g v. 22 |h pp. 665-672 |k n. 5 |p J. Steroid Biochem. |x 00224731 |t Journal of Steroid Biochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0022-4731(85)90221-3 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00224731_v22_n5_p665_Cozza |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v22_n5_p665_Cozza |y Registro en la Biblioteca Digital |
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| 999 | |c 62024 | ||