Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ liga...
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Inc.
2011
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 13143caa a22011177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-10520 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204034.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-79959749781 | |
| 024 | 7 | |2 cas |a arachidonate 12 lipoxygenase, 82391-43-3; metformin, 1115-70-4, 657-24-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FESTA | ||
| 100 | 1 | |a Elia, E.M. | |
| 245 | 1 | 0 | |a Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice |
| 260 | |b Elsevier Inc. |c 2011 | ||
| 270 | 1 | 0 | |m Motta, A. B.; CEFYBO, CONICET, Paraguay 2155, Buenos Aires, Argentina; email: aliciabmotta@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine. |l eng | |
| 593 | |a CEFYBO, CONICET, Paraguay 2155, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Fisiología Biología Molecular y Neurociencia (IFIBYNE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Investigaciones Materno Infantil, Hospital Clínico San Borja-Arriarán, Universidad de Chile, Santiago, Chile | ||
| 690 | 1 | 0 | |a LIPOXYGENASES |
| 690 | 1 | 0 | |a METFORMIN |
| 690 | 1 | 0 | |a PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA |
| 690 | 1 | 0 | |a POLYCYSTIC OVARY SYNDROME |
| 690 | 1 | 0 | |a UTERUS |
| 690 | 1 | 0 | |a ARACHIDONATE 12 LIPOXYGENASE |
| 690 | 1 | 0 | |a METFORMIN |
| 690 | 1 | 0 | |a PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME SYNTHESIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HYPERANDROGENISM |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PREPUBERTY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a UTERUS |
| 700 | 1 | |a Pustovrh, C. | |
| 700 | 1 | |a Amalfi, S. | |
| 700 | 1 | |a Devoto, L. | |
| 700 | 1 | |a Motta, A.B. | |
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