Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats
Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1985
|
| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 07061caa a22012017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-1051 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203024.0 | ||
| 008 | 190411s1985 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0022377571 | |
| 024 | 7 | |2 cas |a 5 aminolevulinate synthase, 9037-14-3; cyclic AMP, 60-92-4; cytochrome P450, 9035-51-2; ferrochelatase, 9012-93-5; heme, 14875-96-8; 5-Aminolevulinate Synthetase, 2.3.1.37; Bucladesine, 362-74-3; Cyclic AMP, 60-92-4; Cytochrome P-450 Enzyme System, 9035-51-2; Ferrochelatase, 4.99.1.1; Glucose, 50-99-7; Heme, 14875-96-8; Phenobarbital, 50-06-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BAMRD | ||
| 100 | 1 | |a Cánepa, E.T. | |
| 245 | 1 | 0 | |a Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| 260 | |c 1985 | ||
| 270 | 1 | 0 | |m Grinstein, M. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Meyer, Schmid, (1978) The Metabolic Basis of Inherited Diseases, pp. 116-1220. , J.B. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, McGraw Hill, New York | ||
| 504 | |a Smith, De Matteis, (1980) Clinics in Haematology, 9, pp. 399-425. , A. Goldberg, M.R. Moore, W.B. Saunders, Philadelphía | ||
| 504 | |a Sterling, Silver, Riketts, (1949) Arch. Int. Med., 84, pp. 965-975 | ||
| 504 | |a Berman, (1956) Z Gesamte Inn Med, 11, pp. 186-188 | ||
| 504 | |a Burnham, Fossnaugh, (1961) Arch. Dermatol., 83, pp. 717-722 | ||
| 504 | |a Goerz, Korda, (1977) Z. Haut., 52, pp. 1165-1174 | ||
| 504 | |a Jefferson, Exton, Butcher, Sutherland, Park, (1968) J. Biol. Chem., 243, pp. 1031-1038 | ||
| 504 | |a Wallaas, Wallaas, Gronnerod, (1972) Isr. J. Med. Sci., 8, pp. 353-357 | ||
| 504 | |a Edwards, Elliot, (1974) J. Biol. Chem., 249, pp. 851-855 | ||
| 504 | |a Cánepa, Llambías, Grinstein, (1984) Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 804, pp. 8-15 | ||
| 504 | |a Cánepa, Llambias, Grinstein, (1985) Biochimica et Biophysica Acta (BBA) - General Subjects, 841, pp. 186-194 | ||
| 504 | |a Fry, Jones, Webkin, Bridges, (1976) Anal. Biochem., 71, pp. 341-350 | ||
| 504 | |a Estabrook, Werringloer, (1978) Methods Enzymol., 52, pp. 212-220 | ||
| 504 | |a Omura, Sato, (1964) J. Biol. Chem., 239, pp. 2370-2378 | ||
| 504 | |a Tsang, Lehotay, Pearson Murphy, (1972) J. Clin. Endocrinol. Metabol., 35, pp. 809-817 | ||
| 504 | |a Cantore, Galvagno, Passeron, (1983) Cell Biol. Int. Rep., 7, pp. 947-954 | ||
| 504 | |a Dubowski, (1962) Clin. Chem., 8, pp. 592-598 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Pilkis, Exton, Johnson, Park, (1974) Biochim. Biophys. Acta, 343, pp. 250-267 | ||
| 504 | |a Israelsson, Tengrup, (1980) Experientia, 36, pp. 257-258 | ||
| 504 | |a Bitar, Weiner, (1983) Biochem. Pharmacol., 32, pp. 1921-1928 | ||
| 504 | |a Bitar, Weiner, (1984) Diabetes, 33, pp. 137-144 | ||
| 504 | |a De Matteis, (1971) Biochem. J., 124, pp. 767-777 | ||
| 504 | |a Bonkowsky, Collins, Doherty, Tschudy, (1973) Biochim. Biophys. Acta, 320, pp. 561-576 | ||
| 504 | |a Giger, Meyer, (1981) J. Biol. Chem., 256, pp. 11182-11190 | ||
| 504 | |a Hoo Tio Tiong, Leynse, Fetkamp, Neuman, (1971) S. Afr. J. Lab. Clin. Med., 17, pp. 199-201 | ||
| 504 | |a Harris, Miels, Levin, (1966) Archives of Internal Medicine, 117, pp. 425-430 | ||
| 520 | 3 | |a Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic acid synthase and ferrochelatase biosynthesis and cyclic AMP content in diabetic hepatic cells is markedly greater than that observed in normal hepatocytes. This stimulatory response is neither enhanced by added dibutyryl cyclic AMP nor repressed by glucose. The present results suggest that the heme pathway of diabetic hepatocytes is more susceptible to porphyrinogenic factors. © 1985. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Secretaria Nacional de Ciencia y Tecnología | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Part of this work was supported by research grants from University of Buenos Aires, Secretaria de Ciencia y Tdcnica and Consejo Nacional de Investigaciones Cientificas y Tdcnicas (Argentina), of which M.A.G. and S.P. are Career Investigators. | ||
| 593 | |a Laboratorio de Porfirinas and Programa de Regulación Hormonal y Metabólica, Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, (1428) Buenos Aires Argentina | ||
| 690 | 1 | 0 | |a (DIABETIC RAT HEPATOCYTE) |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYTOCHROME P-450 |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a FERROCHELATASE |
| 690 | 1 | 0 | |a Δ-AMINOLEVULINIC ACID SYNTHASE |
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYTOCHROME P450 |
| 690 | 1 | 0 | |a FERROCHELATASE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a DIABETES MELLITUS |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a ETIOLOGY |
| 690 | 1 | 0 | |a EXPERIMENTAL DIABETES MELLITUS |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a LIVER CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BUCLADESINE |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYTOCHROME P-450 ENZYME SYSTEM |
| 690 | 1 | 0 | |a DIABETES MELLITUS, EXPERIMENTAL |
| 690 | 1 | 0 | |a FERROCHELATASE |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PHENOBARBITAL |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a REFERENCE VALUES |
| 650 | 1 | 7 | |2 spines |a HOMEOSTASIS |
| 700 | 1 | |a Galvagno, M.A. | |
| 700 | 1 | |a Llambías, E.B.C. | |
| 700 | 1 | |a Passeron, S. | |
| 700 | 1 | |a Grinstein, M. | |
| 773 | 0 | |d 1985 |g v. 847 |h pp. 191-197 |k n. 2 |p Biochim. Biophys. Acta Mol. Cell Res. |x 01674889 |w (AR-BaUEN)CENRE-2263 |t BBA - Molecular Cell Research | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022377571&doi=10.1016%2f0167-4889%2885%2990020-5&partnerID=40&md5=fdb153953b549befb2fcdbb42bcb0eb1 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0167-4889(85)90020-5 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01674889_v847_n2_p191_Canepa |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v847_n2_p191_Canepa |y Registro en la Biblioteca Digital |
| 961 | |a paper_01674889_v847_n2_p191_Canepa |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 62004 | ||