Male and female reproductive toxicity induced by sub-chronic ethanol exposure in CF-1 mice
Since genetic damage induced by ethanol exposure is controversial and incomplete and because germ and somatic cells constitute bioindicators for monitoring reproductive toxicity and genotoxic actions of ethanol consumption, the purpose of the present investigation was to evaluate morphological sperm...
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2011
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| LEADER | 17781caa a22015977a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518204027.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-79959540039 | |
| 024 | 7 | |2 cas |a alcohol, 64-17-5; Ethanol, 64-17-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CBTOE | ||
| 100 | 1 | |a Cebral, E. | |
| 245 | 1 | 0 | |a Male and female reproductive toxicity induced by sub-chronic ethanol exposure in CF-1 mice |
| 260 | |c 2011 | ||
| 270 | 1 | 0 | |m Cebral, E.; LARFIMAE-CONICET, Ciudad Universitaria, Pabellón 2, Intendente Güiraldes 2620, 1428EHA Buenos Aires, Argentina; email: ecebral@hotmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Since genetic damage induced by ethanol exposure is controversial and incomplete and because germ and somatic cells constitute bioindicators for monitoring reproductive toxicity and genotoxic actions of ethanol consumption, the purpose of the present investigation was to evaluate morphological sperm, oocyte alterations and parental genotoxic effects after sub-chronic ethanol intake in the CF-1 outbred mouse strain. Ethanol 10% was administered to CF-1 adult male (treated males, TM) and female (treated females, TF) mice for 27 days, whereas water was given to controls from both sexes too (CM and CF). Post-treatment micronucleus frequency (MN-PCE/1,000/mouse) and gamete morphology were evaluated. To test whether change of female reproductive status results in maternal genotoxicity, CF-1 females received ethanol 10% (exposed group, periconceptionally treated females (PTF)) or water (control group, pregnant control females (PCF)) in drinking water for 17 days previous and up to 10 days of gestation. TM had a high percentage of abnormal spermatozoa vs CM (p < 0.001) and elevated parthenogenetic activated oocyte frequency appeared in TF vs CF (p < 0.001). Sub-chronic ethanol ingestion induced increased MN frequency in TM and TF (p < 0.01). In PTF, where blood alcohol concentrations were between 19-28 mg/dl, very significantly increased MN frequency was found vs PCF (p < 0.01), whereas MN values were similar to TF. These results show that sub-chronic alcohol ingestion in CF-1 mice produces sperm head dysmorphogenesis and oocyte nuclear anomalies, suggesting that morphological abnormalities in germ cells are probably related to parental genotoxicity after ethanol consumption. © 2011 Springer Science+Business Media B.V. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires, 20020090200655 | ||
| 536 | |a Detalles de la financiación: 114-200801-00014, PIPs-CONICET 5,917 | ||
| 536 | |a Detalles de la financiación: PIP-CONICET 5,012 | ||
| 536 | |a Detalles de la financiación: Acknowledgments We thank the enzymatic measures taken at the Toxicology and Legal Chemistry Department of the School of Pharmacology and Biochemistry (FFyB), Universi-dad de Buenos Aires (UBA), Buenos Aires, Argentina. The authors appreciate the help of Dr. Cristian Sobarzo for assembling the figures of photomicrographs. This work was supported by EC-Grants PIPs-CONICET 5,917 and 114-200801-00014, UBACYT 20020090200655 of the UBA, Argentina, and MDM-Grants: PIP-CONICET 5,012 and X107 UBACyT, UBA, Argentina. | ||
| 593 | |a Instituto de Fisiología, Biología Molecular Y Neurociencias (IFIBYNE-CONICET), Departamento de Biodiversidad Y Biología Experimental (DBBE), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina | ||
| 593 | |a Consejo de Investigaciones Científicas Y Técnicas (CONICET), Buenos Aires, Argentina | ||
| 593 | |a Instituto de Astronomía Y Física del Espacio (IAFE) UBA-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Ecología, Genética Y Evolución (EGE), Facultad de Ciencias Exactas Y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina | ||
| 593 | |a LARFIMAE-CONICET, Ciudad Universitaria, Pabellón 2, Intendente Güiraldes 2620, 1428EHA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CF-1 MICE |
| 690 | 1 | 0 | |a ETHANOL |
| 690 | 1 | 0 | |a MICRONUCLEUS |
| 690 | 1 | 0 | |a OOCYTE |
| 690 | 1 | 0 | |a SPERMATOZOA |
| 690 | 1 | 0 | |a ALCOHOL |
| 690 | 1 | 0 | |a ADULT ANIMAL |
| 690 | 1 | 0 | |a ALCOHOL BLOOD LEVEL |
| 690 | 1 | 0 | |a ALCOHOL CONSUMPTION |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL DAMAGE |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CELL STRUCTURE |
| 690 | 1 | 0 | |a CF1 MOUSE |
| 690 | 1 | 0 | |a CONCEPTION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GAMETE |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a GESTATION PERIOD |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICRONUCLEUS |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MOUSE STRAIN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OOCYTE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a REPRODUCTIVE TOXICITY |
| 690 | 1 | 0 | |a SPERM |
| 690 | 1 | 0 | |a ALCOHOL DRINKING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ETHANOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED STRAINS |
| 690 | 1 | 0 | |a MICRONUCLEI, CHROMOSOME-DEFECTIVE |
| 690 | 1 | 0 | |a MUTAGENICITY TESTS |
| 690 | 1 | 0 | |a OOCYTES |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a SPERMATOZOA |
| 690 | 1 | 0 | |a MUS |
| 700 | 1 | |a Abrevaya, X.C. | |
| 700 | 1 | |a Mudry, M.D. | |
| 773 | 0 | |d 2011 |g v. 27 |h pp. 237-248 |k n. 4 |p Cell Biol. Toxicol. |x 07422091 |t Cell Biology and Toxicology | |
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