Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
The inflammatory response is a self-limiting process which involves the sequential activation of signaling pathways leading to the production of both pro- and anti-inflammatory mediators. Galectin-1 (Gal-1), an endogenous lectin found in peripheral lymphoid organs and inflammatory sites, elicits a b...
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2011
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 18910caa a22018617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-10316 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204020.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-80051923641 | |
| 024 | 7 | |2 cas |a I kappa B alpha, 151217-48-0; galectin 1, 258495-34-0; tacrolimus, 104987-11-3; Galectin 1; LGALS1 protein, human; NF-kappa B | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IMCHA | ||
| 100 | 1 | |a Toscano, M.A. | |
| 245 | 1 | 0 | |a Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1 |
| 260 | |c 2011 | ||
| 270 | 1 | 0 | |m Toscano, M.A.; Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obligado 2490, C1428ADN, Ciudad de Buenos Aires, Argentina; email: martalitos@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A., Rabinovich, G.A., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway (2007) J. Immunol., 178, pp. 436-445 | ||
| 504 | |a Blaser, C., Kaufmann, M., Muller, C., Zimmermann, C., Wells, V., Mallucci, L., Pircher, H., Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells (1998) Eur. J. Immunol., 28, pp. 2311-2319 | ||
| 504 | |a Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., Toscano, M.A., Arck, P.C., A pivotal role for galectin-1 in fetomaternal tolerance (2007) Nat. Med., 13, pp. 1450-1457 | ||
| 504 | |a Cartharius, K., Frech, K., Grote, K., Klocke, B., Haltmeier, M., Klingenhoff, A., Frisch, M., Werner, T., MatInspector and beyond: promoter analysis based on transcription factor binding sites (2005) Bioinformatics, 21, pp. 2933-2942 | ||
| 504 | |a Coornaert, B., Carpentier, I., Beyaert, R., A20: central gatekeeper in inflammation and immunity (2009) J. Biol. Chem., 284, pp. 8217-8221 | ||
| 504 | |a Costas, M., Trapp, T., Pereda, M.P., Sauer, J., Rupprecht, R., Nahmod, V.E., Reul, J.M., Arzt, E., Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis (1996) J. Clin. Invest., 98, pp. 1409-1416 | ||
| 504 | |a Fuertes, M.B., Molinero, L.L., Toscano, M.A., Ilarregui, J.M., Rubinstein, N., Fainboim, L., Zwirner, N.W., Rabinovich, G.A., Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase (2004) Mol. Cell. Biochem., 267, pp. 177-185 | ||
| 504 | |a Garin, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells (2007) Blood, 109, pp. 2058-2065 | ||
| 504 | |a Gauthier, S., Pelletier, I., Ouellet, M., Vargas, A., Tremblay, M.J., Sato, S., Barbeau, B., Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity (2008) Retrovirology, 5, pp. 105-119 | ||
| 504 | |a Ghosh, S., Hayden, M.S., New regulators of NF-kappaB in inflammation (2008) Nat. Rev. Immunol., 8, pp. 837-848 | ||
| 504 | |a Green, D.R., Droin, N., Pinkoski, M., Activation-induced cell death in T cells (2003) Immunol. Rev., 193, pp. 70-81 | ||
| 504 | |a Hsu, D.K., Hammes, S.R., Kuwabara, I., Greene, W.C., Liu, F.T., Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3 (1996) Am. J. Pathol., 148, pp. 1661-1670 | ||
| 504 | |a Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., Geffner, J.R., Rabinovich, G.A., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10 (2009) Nat. Immunol., 10, pp. 981-991 | ||
| 504 | |a Imhof, A., Wolffe, A.P., Transcription: gene control by targeted histone acetylation (1998) Curr. Biol., 8, pp. R422-R424 | ||
| 504 | |a Juszczynski, P., Ouyang, J., Monti, S., Rodig, S.J., Takeyama, K., Abramson, J., Chen, W., Shipp, M.A., The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma (2007) Proc. Natl. Acad. Sci. U.S.A., 104, pp. 13134-13139 | ||
| 504 | |a Kavurma, M.M., Khachigian, L.M., Signaling and transcriptional control of Fas ligand gene expression (2003) Cell Death Differ., 10, pp. 36-44 | ||
| 504 | |a Koh, H.S., Lee, C., Lee, K.S., Ham, C.S., Seong, R.H., Kim, S.S., Jeon, S.H., CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation (2008) Biochem. Biophys. Res. Commun., 370, pp. 149-153 | ||
| 504 | |a Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., Rabinovich, G.A., Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings (2010) IUBMB Life, 62, pp. 1-13 | ||
| 504 | |a Lawrence, T., The nuclear factor NF-kappaB pathway in inflammation (2009) Cold Spring Harb. Perspect. Biol., 1, pp. a001651 | ||
| 504 | |a Li, Z.W., Rickert, R.C., Karin, M., Genetic dissection of antigen receptor induced-NF-kappaB activation (2004) Mol. Immunol., 41, pp. 701-714 | ||
| 504 | |a Lin, B., Williams-Skipp, C., Tao, Y., Schleicher, M.S., Cano, L.L., Duke, R.C., Scheinman, R.I., NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type (1999) Cell Death Differ., 6, pp. 570-582 | ||
| 504 | |a Liu, F.T., Rabinovich, G.A., Galectins: regulators of acute and chronic inflammation (2010) Ann. NY Acad. Sci., 1183, pp. 158-182 | ||
| 504 | |a Liu, L., Sakai, T., Sano, N., Fukui, K., Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signaling (2004) Biochem. J., 380, pp. 31-41 | ||
| 504 | |a Motran, C.C., Molinder, K.M., Liu, S.D., Poirier, F., Miceli, M.C., Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function (2008) Eur. J. Immunol., 38, pp. 3015-3027 | ||
| 504 | |a Nieminen, J., Kuno, A., Hirabayashi, J., Sato, S., Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer (2007) J. Biol. Chem., 282, pp. 1374-1383 | ||
| 504 | |a Norling, L.V., Sampaio, A.L., Cooper, D., Perretti, M., Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking (2008) FASEB J., 22, pp. 682-690 | ||
| 504 | |a Pasparakis, M., Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases (2009) Nat. Rev. Immunol., 9, pp. 778-788 | ||
| 504 | |a Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G., Apoptosis of T cells mediated by galectin-1 (1995) Nature, 378, pp. 736-739 | ||
| 504 | |a Perone, M.J., Bertera, S., Tawadrous, Z.S., Shufesky, W.J., Piganelli, J.D., Baum, L.G., Trucco, M., Morelli, A.E., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice (2006) J. Immunol., 177, pp. 5278-5289 | ||
| 504 | |a Rabinovich, G., Castagna, L., Landa, C., Riera, C.M., Sotomayor, C., Regulated expression of a 16-kd galectin-like protein in activated rat macrophages (1996) J. Leukoc. Biol., 59, pp. 363-370 | ||
| 504 | |a Rabinovich, G.A., Daly, G., Dreja, H., Tailor, H., Riera, C.M., Hirabayashi, J., Chernajovsky, Y., Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis (1999) J. Exp. Med., 190, pp. 385-398 | ||
| 504 | |a Rabinovich, G.A., Iglesias, M.M., Modesti, N.M., Castagna, L.F., Wolfenstein-Todel, C., Riera, C.M., Sotomayor, C.E., Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization (1998) J. Immunol., 160, pp. 4831-4840 | ||
| 504 | |a Rabinovich, G.A., Ramhorst, R.E., Rubinstein, N., Corigliano, A., Daroqui, M.C., Kier-Joffe, E.B., Fainboim, L., Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms (2002) Cell Death Differ., 9, pp. 661-670 | ||
| 504 | |a Rabinovich, G.A., Toscano, M.A., Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation (2009) Nat. Rev. Immunol., 9, pp. 338-352 | ||
| 504 | |a Renner, F., Schmitz, M.L., Autoregulatory feedback loops terminating the NF-kappaB response (2009) Trends Biochem. Sci., 34, pp. 128-135 | ||
| 504 | |a Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege (2004) Cancer Cell, 5, pp. 241-251 | ||
| 504 | |a Santucci, L., Fiorucci, S., Rubinstein, N., Mencarelli, A., Palazzetti, B., Federici, B., Rabinovich, G.A., Morelli, A., Galectin-1 suppresses experimental colitis in mice (2003) Gastroenterology, 124, pp. 1381-1394 | ||
| 504 | |a Satelli, A., Rao, U.S., Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells (2011) Cancer Lett., 301, pp. 38-46 | ||
| 504 | |a Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death (2006) J. Immunol., 176, pp. 778-789 | ||
| 504 | |a Stowell, S.R., Qian, Y., Karmakar, S., Koyama, N.S., Dias-Baruffi, M., Leffler, H., McEver, R.P., Cummings, R.D., Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion (2008) J. Immunol., 180, pp. 3091-3102 | ||
| 504 | |a Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Croci, D.O., Correale, J., Hernandez, J.D., Zwirner, N.W., Rabinovich, G.A., Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death (2007) Nat. Immunol., 8, pp. 825-834 | ||
| 504 | |a Toscano, M.A., Commodaro, A.G., Ilarregui, J.M., Bianco, G.A., Liberman, A., Serra, H.M., Hirabayashi, J., Rabinovich, G.A., Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses (2006) J. Immunol., 176, pp. 6323-6332 | ||
| 504 | |a Vallabhapurapu, S., Karin, M., Regulation and function of NF-kappaB transcription factors in the immune system (2009) Annu. Rev. Immunol., 27, pp. 693-733 | ||
| 504 | |a van der Leij, J., van den Berg, A., Harms, G., Eschbach, H., Vos, H., Zwiers, P., van Weeghel, R., Visser, L., Strongly enhanced IL-10 production using stable galectin-1 homodimers (2007) Mol. Immunol., 44, pp. 506-513 | ||
| 504 | |a van Kooyk, Y., Rabinovich, G.A., Protein-glycan interactions in the control of innate and adaptive immune responses (2008) Nat. Immunol., 9, pp. 593-601 | ||
| 504 | |a Vereecke, L., Beyaert, R., van Loo, G., The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology (2009) Trends Immunol., 30, pp. 383-391 | ||
| 504 | |a Werbajh, S., Nojek, I., Lanz, R., Costas, M.A., RAC-3 is a NF-kappa B coactivator (2000) FEBS Lett., 485, pp. 195-199 | ||
| 504 | |a Zuñiga, E., Rabinovich, G.A., Iglesias, M.M., Gruppi, A., Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis (2001) J. Leukoc. Biol., 70, pp. 73-79 | ||
| 520 | 3 | |a The inflammatory response is a self-limiting process which involves the sequential activation of signaling pathways leading to the production of both pro- and anti-inflammatory mediators. Galectin-1 (Gal-1), an endogenous lectin found in peripheral lymphoid organs and inflammatory sites, elicits a broad spectrum of biological functions predominantly by acting as a potent anti-inflammatory factor and as a suppressive agent for T-cell responses. However, the molecular pathways underlying Gal-1 expression and function remain poorly understood. Here we identified a regulatory loop linking Gal-1 expression and function to NF-κB activation. NF-κB-activating stimuli increased Gal-1 expression on T cells, an effect which could be selectively prevented by inhibitors of NF-κB signaling. Accordingly, transient transfection of the p65 subunit of NF-κB was sufficient to induce high Gal-1 expression. Using in silico studies and chromatin immunoprecipitation analysis we have identified a functional NF-κB binding site within the first intron of the LGALS1 gene. In addition, our results show that exogenous Gal-1 can attenuate NF-κB activation, as shown by inhibition of IκB-α degradation induced by pro-inflammatory stimuli, higher cytoplasmic retention of p65, lower NF-κB DNA binding activity and impaired transcriptional activation of target genes. The present study suggest a novel regulatory loop by which NF-κB induces expression of Gal-1, which in turn may lead to negative control of NF-κB signaling. © 2011 Elsevier Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Mizutani Foundation for Glycoscience | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT, PICT 2010-087 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBA | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET | ||
| 536 | |a Detalles de la financiación: This study was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica ( PICT 2010-087 ; Argentina), Fundación Sales (Argentina), Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Universidad de Buenos Aires (Argentina), Mizutani Foundation for Glycoscience (Japan) and Prostate Cancer Research Foundation (UK). We thank J. Stupirski and V. Martinez Allo for technical assistance. | ||
| 593 | |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Inmunogenética, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Biología Molecular y Apoptosis, Instituto de Investigaciones Médicas Alfredo Lanari (IDIM), Consejo Nacional de Investigaciones Cientificasy Tecnologicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-UBA Consejo Nacional de Investigaciones Cientificas y Técnicas of Argentina, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Museo Argentino de Ciencias Naturales Bernardino Rivadavia, Av. Ángel Gallardo 470, C1405DJR, Buenos Aires, Argentina | ||
| 593 | |a Department of Medicine, The University of Chicago, MC0930, Chicago, IL 60637, United States | ||
| 593 | |a Institute of Biochemistry, Swiss Federal Institute of Technology Zurich (ETHZ), Schafmattstrasse 18, CH-8093 Zurich, Switzerland | ||
| 690 | 1 | 0 | |a GALECTIN-1 |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a NF-ΚB |
| 690 | 1 | 0 | |a T CELLS |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a GLYCAN |
| 690 | 1 | 0 | |a I KAPPA B ALPHA |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN ENHANCER BINDING PROTEIN |
| 690 | 1 | 0 | |a PROTEIN SUBUNIT |
| 690 | 1 | 0 | |a SYNAPTOTAGMIN I |
| 690 | 1 | 0 | |a TACROLIMUS |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR ALPHA |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BINDING SITE |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CHROMATIN IMMUNOPRECIPITATION |
| 690 | 1 | 0 | |a CHROMOSOME 22 |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOPLASM |
| 690 | 1 | 0 | |a DNA BINDING |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a GENE TARGETING |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a INHIBITION KINETICS |
| 690 | 1 | 0 | |a INTRON |
| 690 | 1 | 0 | |a PERIPHERAL BLOOD MONONUCLEAR CELL |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN ANALYSIS |
| 690 | 1 | 0 | |a PROTEIN DEGRADATION |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a PROTEIN PROTEIN INTERACTION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a TH1 CELL |
| 690 | 1 | 0 | |a TH2 CELL |
| 690 | 1 | 0 | |a TRANSCRIPTION INITIATION |
| 690 | 1 | 0 | |a TRANSCRIPTION INITIATION SITE |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a BINDING SITES |
| 690 | 1 | 0 | |a BLOTTING, WESTERN |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a CHROMATIN IMMUNOPRECIPITATION |
| 690 | 1 | 0 | |a ELECTROPHORETIC MOBILITY SHIFT ASSAY |
| 690 | 1 | 0 | |a FEEDBACK, PHYSIOLOGICAL |
| 690 | 1 | 0 | |a GALECTIN 1 |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MICROSCOPY, CONFOCAL |
| 690 | 1 | 0 | |a NF-KAPPA B |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a T-LYMPHOCYTES |
| 690 | 1 | 0 | |a TRANSFECTION |
| 700 | 1 | |a Campagna, L. | |
| 700 | 1 | |a Molinero, L.L. | |
| 700 | 1 | |a Cerliani, J.P. | |
| 700 | 1 | |a Croci, D.O. | |
| 700 | 1 | |a Ilarregui, J.M. | |
| 700 | 1 | |a Fuertes, M.B. | |
| 700 | 1 | |a Nojek, I.M. | |
| 700 | 1 | |a Fededa, J.P. | |
| 700 | 1 | |a Zwirner, N.W. | |
| 700 | 1 | |a Costas, M.A. | |
| 700 | 1 | |a Rabinovich, G.A. | |
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