Synthesis of |21‐14C|‐3β‐hydroxy‐5β‐pregnan‐20‐one and |21‐14C|‐5β‐cholestan‐3β‐ol

|21‐14C|‐3β‐Hydroxy‐5β‐pregnan‐20‐one was synthesised from 3β‐acetoxy‐5β‐androstan‐17β‐carboxylic acid chloride and |14C2|dimethyl‐cadmium. Reaction of the labelled product with isohexyl bromide yielded, after dehydration and catalytic hydrogenation, |21‐14C|‐5β‐cholestan‐3β‐ol (|21‐14C|‐coprostanol...

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Detalles Bibliográficos
Autor principal: Garraffo, H.M
Otros Autores: Deluca, M.E, Seldes, A.M, Gross, E.G
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1985
Acceso en línea:Registro en Scopus
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100 1 |a Garraffo, H.M. 
245 1 0 |a Synthesis of |21‐14C|‐3β‐hydroxy‐5β‐pregnan‐20‐one and |21‐14C|‐5β‐cholestan‐3β‐ol 
260 |c 1985 
270 1 0 |m Garraffo, H.M.; Departamento de Química Orgánica Y Umymfor, Faculated de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, 1428, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Galagovsky, L.R., Porto, A.M., Burton, G., Gros, E.G., (1984) Z. Naturforsch., 39 c, p. 38. , and previous papers cited therein 
504 |a Garraffo, H.M., Gros, E.G., (1982) J. Lab. Compds. Radiopharm., 19, p. 149 
504 |a Deluca, M.E., Seldes, A.M., Garraffo, H.M., Gros, E.G., Z. Naturforsch. in press; Riegel, B., Prout, F.S., (1948) J. Org. Chem., 13, p. 933 
504 |a Mac Phillamy, H.B., Scholz, C.R., (1949) J. Biol. Chem., 178, p. 37 
504 |a Porto, A.M., Gros, E.G., Synthesis of PREGN-5-en-3β-o1-20-one-20-14C (1968) Journal of Labelled Compounds, 4, p. 276 
504 |a Marker, R.E., Kamm, O., Wittle, E.L., (1937) J. Am. Chem. Soc., 59, p. 1841 
504 |a Sabetay, S., Bléger, J., (1930) Bull. Soc. Chim. France, 47, p. 885 
504 |a Fieser, L.F., Fieser, M., (1959) Steroids, p. 28. , Reinhold Pub. Corp., N.Y 
504 |a Engelhardt, G., Zeigan, D., Schönecker, B., 3C-NMR-Untersuchungen an Steroiden, III. Sterische Effekte von 2,3-substituierten Cholestanderivaten und deren Anwendung zur Konfigurationsbestimmung (1978) J. Prakt. Chem., 320, p. 377 
520 3 |a |21‐14C|‐3β‐Hydroxy‐5β‐pregnan‐20‐one was synthesised from 3β‐acetoxy‐5β‐androstan‐17β‐carboxylic acid chloride and |14C2|dimethyl‐cadmium. Reaction of the labelled product with isohexyl bromide yielded, after dehydration and catalytic hydrogenation, |21‐14C|‐5β‐cholestan‐3β‐ol (|21‐14C|‐coprostanol). Copyright © 1985 John Wiley & Sons, Ltd.  |l eng 
593 |a Departamento de Química Orgánica Y Umymfor, Faculated de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, 1428, Argentina 
690 1 0 |a SYNTHESIS 
690 1 0 |a |21‐14C|‐3Β‐HYDROXY‐5Β‐PREGNAN‐20‐ONE 
690 1 0 |a |21‐14C|‐COPROSTANOL 
690 1 0 |a RADIOISOTOPE 
690 1 0 |a 5BETA PREGNAN 3BETA OL 20 ONE C 14 
690 1 0 |a COPROSTEROL C 14 
690 1 0 |a DRUG ANALYSIS 
690 1 0 |a DRUG IDENTIFICATION 
690 1 0 |a DRUG SYNTHESIS 
690 1 0 |a MASS SPECTROMETRY 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEAR MAGNETIC RESONANCE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTON NUCLEAR MAGNETIC RESONANCE 
690 1 0 |a THEORETICAL STUDY 
700 1 |a Deluca, M.E. 
700 1 |a Seldes, A.M. 
700 1 |a Gross, E.G. 
773 0 |d 1985  |g v. 22  |h pp. 673-676  |k n. 7  |p J. Label. Compd. Radiopharm.  |x 03624803  |w (AR-BaUEN)CENRE-1949  |t Journal of Labelled Compounds and Radiopharmaceuticals 
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856 4 0 |u https://doi.org/10.1002/jlcr.2580220706  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_03624803_v22_n7_p673_Garraffo  |y Handle 
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999 |c 61980