A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness

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Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started in the early 1990s and...

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Otros Autores: Bei, Jinlong, Bigi, María Mercedes, Zhang, Qi, Blanco, Federico Carlos, López, Beatriz, Sasiain, María del Carmen, Soria, Marcelo Abel, Bigi, Fabiana
Formato: Artículo
Lenguaje:Inglés
Materias:
MYCOBACTERIUM TUBERCULOSIS
PHENOTYPIC CHARACTERIZATION
EPIDEMIOLOGICAL
Acceso en línea:http://ri.agro.uba.ar/files/download/articulo/2021beijinlong.pdf
LINK AL EDITOR
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central (FAUBA) de Universidad de Buenos Aires
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024 |a 10.1155/2020/4741237 
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245 1 0 |a A phenotypic characterization of two isolates of a multidrug - resistant outbreak strain of Mycobacterium tuberculosis with opposite epidemiological fitness 
520 |a Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started in the early 1990s and in the mid 2000s still accounted for 29% of all MDR-TB cases in Argentina. By contrast, a clonal variant of strain M, named 410, has caused a single tuberculosis case since the onset of the outbreak. The molecular bases of the high epidemiological fitness of the M strain remain unclear. To assess its unique molecular properties, herein, we performed a comparative protein and lipid analysis of a representative clone of the M strain (Mp) and the nonprosperous M variant 410. We also evaluated their growth in low pH. The variant 410 had higher levels of latency proteins under standard conditions and delayed growth at low pH, suggesting that it is more sensitive to stress stimuli than Mp. Moreover, Mp showed higher levels of mycolic acids covalently attached to the cell wall and lower accumulation of free mycolic acids in the outer layer than the 410 strain. The low expression of latency proteins together with the reduced content of surface mycolic acids may facilitate Mp to evade the host immune responses. 
650 |2 Agrovoc  |9 26 
653 |a MYCOBACTERIUM TUBERCULOSIS 
653 |a PHENOTYPIC CHARACTERIZATION 
653 |a EPIDEMIOLOGICAL 
700 1 |a Bei, Jinlong  |u Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China.  |9 72936 
700 1 |9 67558  |a Bigi, María Mercedes  |u Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. 
700 1 |a Zhang, Qi  |u Guangdong Academy of Agricultural Sciences (GDAAS). AGRO-Biological Gene Research Center, Guangzhou, China.  |9 72938 
700 1 |a Blanco, Federico Carlos  |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina.  |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina.  |9 70699 
700 1 |a López, Beatriz  |u Instituto Nacional de Enfermedades Infecciosas - ANLIS Carlos Malbrán. Buenos Aires, Argentina.  |9 67559 
700 1 |a Sasiain, María del Carmen  |u Academia Nacional de Medicina (IMEX). Buenos Aires, Argentina.  |u CONICET - Academia Nacional de Medicina (IMEX). Buenos Aires, Argentina.  |9 67561 
700 1 |a Soria, Marcelo Abel  |u Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina.  |9 49057 
700 1 |9 48059  |a Bigi, Fabiana  |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina.  |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. 
773 |t BioMed research international  |g Vol.20 (2020), art.4741237, 9 p., grafs., fot. 
856 |f 2021beijinlong  |i En internet  |q application/pdf  |u http://ri.agro.uba.ar/files/download/articulo/2021beijinlong.pdf  |x ARTI202103 
856 |u https://www.hindawi.com/  |z LINK AL EDITOR 
942 |c ARTICULO 
942 |c ENLINEA 
976 |a AAG 

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