Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a p...
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| Otros Autores: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/download/articulo/2019forrellad.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
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| 005 | 20221004171446.0 | ||
| 008 | 200518t2019 xxkdo|||o|||| 00| | eng d | ||
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| 022 | |a 2150-5608 | ||
| 024 | |a 10.1080/21505594.2019.1693714 | ||
| 040 | |a AR-BaUFA | ||
| 245 | 1 | 0 | |a Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress |
| 520 | |a In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a protein linked to nitrosative stress. Here, we showed that knockout of the Rv2617c gene in M. tuberculosis CDC1551 reduced the replication of the pathogen in a mouse model of infection and favored the trafficking of mycobacteria to phagolysosomes. We also demonstrated that Rv2617c and P36 are required for resistance to in vitro hydrogen peroxide treatment in M. tuberculosis and Mycobacterium bovis, respectively. These findings indicate Rv2617c and P36 act in concert to prevent bacterial damage upon oxidative stress. | ||
| 653 | |a MYCOBACTERIUM TUBERCULOSIS | ||
| 653 | |a OXIDATIVE STRESS | ||
| 653 | |a VIRULENCE FACTOR | ||
| 653 | |a MYCOBACTERIUM TUBERCULOSIS | ||
| 653 | |a RV2617C | ||
| 653 | |a ERP | ||
| 700 | 1 | |9 67949 |a Forrellad, Marina Andrea |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. | |
| 700 | 1 | |9 67948 |a Vázquez, Cristina Lourdes |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. | |
| 700 | 1 | |9 70699 |a Blanco, Federico Carlos |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. | |
| 700 | 1 | |a Klepp, Laura Inés |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. |9 68513 | |
| 700 | 1 | |a García, Elizabeth A. |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. |9 67947 | |
| 700 | 1 | |9 67950 |a Rocha, Rosana Valeria |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. | |
| 700 | 1 | |a Villafañe, Luciana |u Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. |u CONICET - Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología molecular (IABIMO). Hurlingham, Buenos Aires, Argentina. |9 70700 | |
| 700 | 1 | |9 67558 |a Bigi, María Mercedes |u Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. | |
| 773 | 0 | |t Virulence |g Vol.10, no.1 (2019), p.1026–1033, grafs., fot. | |
| 856 | |f 2019forrellad |i en internet |q application/pdf |u http://ri.agro.uba.ar/files/download/articulo/2019forrellad.pdf |x ARTI202003 | ||
| 856 | |z LINK AL EDITOR |u https://taylorandfrancis.com | ||
| 942 | |c ARTICULO | ||
| 942 | |c ENLINEA | ||
| 976 | |a AAG | ||