Alkaloids from Hippeastrum argentinum and their Cholinesterase inhibitory activities an in vitro and in silico study
Two new alkaloids, 4-O-methylnangustine [1] and 7-hydroxyclivonine [2] [montanine and homolycorine types, respectively], and four known alkaloids were isolated from the bulbs of Hippeastrum argentinum, and their cholinesterase inhibitory activities were evaluated. These compounds were identified usi...
| Otros Autores: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2016ortiz.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 02195cab a22003857a 4500 | ||
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| 001 | AR-BaUFA000989 | ||
| 003 | AR-BaUFA | ||
| 005 | 20220418154109.0 | ||
| 008 | 181208t2016 |||||o|||||00||||eng d | ||
| 999 | |c 47345 |d 47345 | ||
| 999 | |d 47345 | ||
| 999 | |d 47345 | ||
| 022 | |a 0163-3864 | ||
| 024 | |a 10.1021/acs.jnatprod.5b00785 | ||
| 040 | |a AR-BaUFA |c AR-BaUFA | ||
| 245 | 1 | 0 | |a Alkaloids from Hippeastrum argentinum and their Cholinesterase inhibitory activities |b an in vitro and in silico study |
| 520 | |a Two new alkaloids, 4-O-methylnangustine [1] and 7-hydroxyclivonine [2] [montanine and homolycorine types, respectively], and four known alkaloids were isolated from the bulbs of Hippeastrum argentinum, and their cholinesterase inhibitory activities were evaluated. These compounds were identified using GC-MS, and their structures were defined by physical data analysis. Compound 2 showed weak butyrylcholinesterase [BuChE]-inhibitory activity, with a half-maximal inhibitory concentration [IC50] value of 67.3 ± 0.09 ìM. To better understand the experimental results, a molecular modeling study was also performed. The combination of a docking study, molecular dynamics simulations, and quantum theory of atoms in molecules calculations provides new insight into the molecular interactions of compound 2 with BuChE, which were compared to those of galantamine. | ||
| 653 | 0 | |a ALKALOIDS | |
| 653 | 0 | |a HIPPEASTRUM ARGENTINUM | |
| 653 | 0 | |a CHOLINESTERASE | |
| 700 | 1 | |9 67699 |a Ortiz, Javier E. | |
| 700 | 1 | |9 67701 |a Pigni, Natalia B. | |
| 700 | 1 | |a Andujar, Sebastián A. |9 70214 | |
| 700 | 1 | |a Roitman, Gustavo Germán |9 7391 | |
| 700 | 1 | |a Suvire, Fernando D. |9 70215 | |
| 700 | 1 | |9 67705 |a Enriz, Ricardo D. | |
| 700 | 1 | |9 67804 |a Tapia, Alejandro | |
| 700 | 1 | |9 67803 |a Bastida, Jaume | |
| 700 | 1 | |9 67706 |a Feresin, Gabriela E. | |
| 773 | |t Journal of Natural Products |g vol.79, no.5 (2016), p.1241-1248, il., tbls., grafs. | ||
| 856 | |u http://ri.agro.uba.ar/files/intranet/articulo/2016ortiz.pdf |i En reservorio |q application/pdf |f 2016ortiz |x MIGRADOS2018 | ||
| 856 | |u https://pubs.acs.org/journal/jnprdf |z LINK AL EDITOR | ||
| 942 | 0 | 0 | |c ARTICULO |
| 942 | 0 | 0 | |c ENLINEA |
| 976 | |a AAG | ||