Longitudinal analysis of the effects of IGF1 - SnaBI genotypes on the growth curve of Angus bull calves
The Insulin Growth Factor 1 [IGF1] has been proposed as a candidate gene for growth related traits as it plays a central role in growth and development of mammals. A relationship between serum IGF1 concentration and different growth traits in cattle has been documented. Furthermore, the IGF1-SnaBI S...
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| Otros Autores: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2013rogbergmunoz.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| Sumario: | The Insulin Growth Factor 1 [IGF1] has been proposed as a candidate gene for growth related traits as it plays a central role in growth and development of mammals. A relationship between serum IGF1 concentration and different growth traits in cattle has been documented. Furthermore, the IGF1-SnaBI SNP in the gene promoter region influences gene expression and IGF1 blood level. The current research was conducted to perform a genetic analysis of longitudinal data for growth curves through the evaluation of the influence of IGF1-SnaBI genotypes on the growth curve of beef cattle during highly anabolic stages. Data were taken on 275 Angus bull calves on two consecutive years, in two commercial cow-calf operations. Calves were weighed at birth, at weaning, and at 3 to 4 times before the year of age. A random regression animal model was employed for the analysis. Fixed effects were age of dam, herd-year, and age of calf [linear and quadratic terms nested within IGF1-SnaBI genotype]. Random effects were age at measure [linear and a quadratic terms nested within animal]. The analysis showed significant differences [P less than 0.01] in the growth curves at ages in between 66 and 291 days for the IGF1-SnaBI genotypes. At 210 days of age, the effect of substituting a T by a C was estimated to be 5.21. kg. These results suggest that the effect of IGF1-SnaBI over growth in cattle take place mostly before puberty. |
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| ISSN: | 1871-1413 |