Polymorphisms in two candidate genes for beef quality in Argentina
Meat quality is a term used to describe a range of attributes of meat. It is determined by genetic and environmental factors [slaughter age, feeding and pre and post-slaughter management]. The current tendency is to study the candidate genes in order to develop molecular markers, which might be used...
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| Formato: | Artículo |
| Lenguaje: | Español |
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| Acceso en línea: | http://ri.agro.uba.ar/files/download/articulo/2011BrandaSica.pdf LINK AL EDITOR |
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| 245 | 1 | 0 | |a Polymorphisms in two candidate genes for beef quality in Argentina |
| 246 | 0 | 0 | |a Variantes en dos genes candidatos para características de calidad de carne bovina en Argentina |
| 520 | |a Meat quality is a term used to describe a range of attributes of meat. It is determined by genetic and environmental factors [slaughter age, feeding and pre and post-slaughter management]. The current tendency is to study the candidate genes in order to develop molecular markers, which might be used for marker-assisted selection. The objective of this work was to evaluate the effect of polymorphisms [SNP, single nucleotide polymorphisms] in candidate genes for tenderness and fat content in steers fattened in grazing beef production systems of Argentina. Molecular methods were designed to analyze the SNP 4751 [C/T] in bovine capn1 gene [large subunit of u-calpain], associated with tenderness and two polymorphisms [exon 8:G/A and intron 9:C/T] in bovine ppargc1a gene [peroxisome proliferatoractivated receptor gamma coactivator 1-alpha] with effect on fat content in cow milk and fiber type in pigs. Information of Warner-Bratzler shear force and fat content from 60 Brangus and 21 Angus steers was used in association studies. Tenderness of cooked meat was evaluated at 1.7 and 14 days post-mortem. A large proportion of animals were heterozygotes [CT] at SNP 4751. No differences were found between genotypes of this SNP for WBSF. A low frequency of homozygote TT was found at SNP on intron 9 of the ppargc1a gene. This SNP showed no significant effect on WBSF and fat content. Two new SNPs [G/A and T/C] were identified within exon 8 of the ppargc1a gene, by multiple alignment of DNA sequences obtained from 24 bulls of different breeds [Angus, Brangus, Brahman and Braford]. One of them [G/A] could be the cause of aminoacid substitution of serine by asparagine at position 364 of the protein. The A allele was not found in Angus. The SNP T/ C is a conservative substitution. It is important that Argentina generate information about factors affecting meat quality for optimizing the production and exportation of high quality beef. | ||
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| 700 | 1 | |9 44542 |a Mezzadra, Carlos Alberto | |
| 700 | 1 | |9 29976 |a Schor, Alejandro | |
| 700 | 1 | |9 33628 |a Miquel, María Cristina | |
| 773 | |t Archivos de Zootecnia |g Vol.60, no.231 (2011), p.521-532 | ||
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| 900 | |a ^tPolymorphisms in two candidate genes for beef quality in Argentina | ||
| 900 | |a ^tVariantes en dos genes candidatos para características de calidad de carne bovina en Argentina | ||
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| 900 | |a ^aBranda Sica^bA.^tUnidad de BiotecnologÃa, INIA, Las Brujas, Uruguay | ||
| 900 | |a ^aSoria^bL.A.^tFacultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina | ||
| 900 | |a ^aCorva^bP.M.^tFacultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce, Argentina | ||
| 900 | |a ^aVillarreal^bE.L.^tInstituto Nacional de TecnologÃa Agropecuaria, Balcarce, Argentina | ||
| 900 | |a ^aMelucci^bL.M.^tFacultad de AgronomÃa, Universidad de Buenos Aires, Argentina | ||
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| 900 | |a Meat quality is a term used to describe a range of attributes of meat. It is determined by genetic and environmental factors [slaughter age, feeding and pre and post-slaughter management]. The current tendency is to study the candidate genes in order to develop molecular markers, which might be used for marker-assisted selection. The objective of this work was to evaluate the effect of polymorphisms [SNP, single nucleotide polymorphisms] in candidate genes for tenderness and fat content in steers fattened in grazing beef production systems of Argentina. Molecular methods were designed to analyze the SNP 4751 [C/T] in bovine capn1 gene [large subunit of u-calpain], associated with tenderness and two polymorphisms [exon 8:G/A and intron 9:C/T] in bovine ppargc1a gene [peroxisome proliferatoractivated receptor gamma coactivator 1-alpha] with effect on fat content in cow milk and fiber type in pigs. Information of Warner-Bratzler shear force and fat content from 60 Brangus and 21 Angus steers was used in association studies. Tenderness of cooked meat was evaluated at 1.7 and 14 days post-mortem. A large proportion of animals were heterozygotes [CT] at SNP 4751. No differences were found between genotypes of this SNP for WBSF. A low frequency of homozygote TT was found at SNP on intron 9 of the ppargc1a gene. This SNP showed no significant effect on WBSF and fat content. Two new SNPs [G/A and T/C] were identified within exon 8 of the ppargc1a gene, by multiple alignment of DNA sequences obtained from 24 bulls of different breeds [Angus, Brangus, Brahman and Braford]. One of them [G/A] could be the cause of aminoacid substitution of serine by asparagine at position 364 of the protein. The A allele was not found in Angus. The SNP T/ C is a conservative substitution. It is important that Argentina generate information about factors affecting meat quality for optimizing the production and exportation of high quality beef. | ||
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