Estimates of the actual relationship between half - sibs in a pig population

Genomic relationships based on markers capture the actual instead of the expected (based on pedigree) proportion of genome shared identical by descent (IBD). Several methods exist to estimate genomic relationships. In this research, we compare four such methods that were tested looking at the empiri...

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Detalles Bibliográficos
Otros Autores: García Baccino, Carolina Andrea, Munilla Leguizamón, Sebastián, Legarra, Andres, Vitezica, Zulma Gladis, Forneris, Natalia Soledad, Bates, R. O., Ernst, C. W., Raney, N. E., Steibel, Juan Pedro, Cantet, Rodolfo Juan Carlos
Formato: Artículo
Lenguaje:Inglés
Materias:
ACTUAL RELATIONSHIPS
ESTIMATION METHODS
GENOMIC SELECTION
IDENTITY BY DESCENT
Acceso en línea:http://ri.agro.uba.ar/files/intranet/articulo/2017garciabaccino.pdf
LINK AL EDITOR
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central (FAUBA) de Universidad de Buenos Aires
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245 |a Estimates of the actual relationship between half - sibs in a pig population 
520 |a Genomic relationships based on markers capture the actual instead of the expected (based on pedigree) proportion of genome shared identical by descent (IBD). Several methods exist to estimate genomic relationships. In this research, we compare four such methods that were tested looking at the empirical distribution of the estimated relationships across 6704 pairs of half - sibs from a cross - bred pig population. The first method based on multiple marker linkage analysis displayed a mean and standard deviation (SD) in close agreement with the expected ones and was robust to changes in the minor allele frequencies (MAF). A single marker method that accounts for linkage disequilibrium (LD) and inbreeding came second, showing more sensitivity to changes in the MAF. Another single marker method that considers neither inbreeding nor LD showed the smallest empirical SD and was the most sensible to changes in MAF. A higher mean and SD were displayed by VanRaden’s method, which was not sensitive to changes in MAF. Therefore, the method based on multiple marker linkage analysis and the single marker method that considers LD and inbreeding performed closer to theoretical values and were consistent with the estimates reported in literature for human half-sibs. 
653 |a ACTUAL RELATIONSHIPS 
653 |a ESTIMATION METHODS 
653 |a GENOMIC SELECTION 
653 |a IDENTITY BY DESCENT 
700 1 |9 33814  |a García Baccino, Carolina Andrea  |u Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal. Buenos Aires, Argentina  |u CONICET – Universidad de Buenos Aires. Buenos Aires, Argentina. 
700 1 |9 13019  |a Munilla Leguizamón, Sebastián  |u Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal. Buenos Aires, Argentina 
700 1 |9 67204  |a Legarra, Andres  |u INRA, GenPhySE (Génétique, Physiologie et Systémes d’Elevage), Castanet-Tolosan, France 
700 1 |9 7786  |a Vitezica, Zulma Gladis  |u INRA, GenPhySE (Génétique, Physiologie et Systémes d’Elevage), Castanet-Tolosan, France  |u Université de Toulouse.Génétique, Physiologie et Systémes d’Elevage (INP, ENSAT, GenPhySE). Castanet-Tolosan, France. 
700 1 |9 29153  |a Forneris, Natalia Soledad  |u Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal. Buenos Aires, Argentina.  |u CONICET – Universidad de Buenos Aires. Buenos Aires, Argentina. 
700 1 |9 67472  |a Bates, R. O.  |u Michigan State University. Department of Animal Science. East Lansing, MI, USA. 
700 1 |9 67473  |a Ernst, C. W.  |u Michigan State University. Department of Animal Science. East Lansing, MI, USA. 
700 1 |a Raney, N. E.  |u Michigan State University. Department of Animal Science. East Lansing, MI, USA.  |9 67474 
700 1 |9 13048  |a Steibel, Juan Pedro  |u Michigan State University. Department of Animal Science. East Lansing, MI, USA.  |u Michigan State University. Department of Fisheries and Wildlife. East Lansing, MI, USA. 
700 1 |9 12817  |a Cantet, Rodolfo Juan Carlos  |u Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Animal. Buenos Aires, Argentina.  |u Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigaciones en Producción Animal (INPA). Buenos Aires, Argentina.  |u CONICET - Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigaciones en Producción Animal (INPA). Buenos Aires, Argentina. 
773 0 |t Journal of animal breeding and genetics  |w SECS000108  |g Vol.134, no.2 (2017), p.109-118, grafs., tbls. 
856 |f 2017garciabaccino  |i en intranet  |q application/pdf  |u http://ri.agro.uba.ar/files/intranet/articulo/2017garciabaccino.pdf  |x ARTI201807 
856 |u https://www.wiley.com  |z LINK AL EDITOR 
942 |c ARTICULO 
942 |c ENLINEA 
976 |a AAG 

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