Article Coarse-grained model Cryo-TEM Lipid Bilayers Liposomes Micelles Microscopy, Electron Molecular Conformation Molecular Dynamics Simulation Molecular dynamics Poloxamer SAXS Scattering, Small Angle Sumatriptan X ray crystallography X ray diffraction X-Ray Diffraction bilayer membrane chemistry conformation controlled study cryogenic transmission electron microscopy drug adsorption drug delivery system drug distribution electron microscopy electrophoretic mobility environment lipid bilayer lipid vesicle