Article Schizosaccharomyces pombe bioaccumulation cell death cell elongation cellular distribution chemical modification conformation congenital disorder of glycosylation controlled study deglucosylation endoplasmic reticulum enzyme activity fungal cell fungal cell wall fungus growth gene mutation glucosidase glucosidase I glucosyltransferase nonhuman phenotype priority journal protein degradation protein expression protein folding protein misfolding transmission electron microscopy unclassified drug