Arthritis, Rheumatoid Gene Therapy Genetic Vectors Humans antirheumatic agent antisense oligonucleotide cell type clinical trial complement system cytokine cytokine receptor gene targeting gene therapy human immunoglobulin enhancer binding protein immunoglobulin fragment interleukin 1 interleukin 1 receptor blocking agent interleukin 10 major clinical study mediator meta analysis plasmid DNA priority journal review rheumatoid arthritis transforming growth factor beta1 tumor necrosis factor alpha tumor necrosis factor alpha antibody virus vector