XML
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:doc="http://www.lyncode.com/xoai" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>I33-R139123456789-11230</identifier><datestamp>2021-03-02T04:25:20Z</datestamp>
<dc:title>Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor</dc:title>
<dc:creator>Monti Hughe, Andrea</dc:creator>
<dc:creator>Longhino, Juan</dc:creator>
<dc:creator>Boggio, Esteban</dc:creator>
<dc:creator>Medin, Vanina A.</dc:creator>
<dc:creator>Martinel Lamas, Diego José</dc:creator>
<dc:creator>Garabalin, Marcela A.</dc:creator>
<dc:creator>Heber, Elisa M.</dc:creator>
<dc:creator>Pozzi, Emiliano C. C.</dc:creator>
<dc:creator>Itoiz, María E.</dc:creator>
<dc:creator>Aromando, Romina F.</dc:creator>
<dc:creator>Nigg, David W.</dc:creator>
<dc:creator>Trivillin, Verónica A.</dc:creator>
<dc:creator>Schwint, Amanda E.</dc:creator>
<dc:subject>TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT)</dc:subject>
<dc:subject>CONFIGURACION RA-6</dc:subject>
<dc:subject>BOLSA DE MEJILLA DE HAMSTER MODELO DE CÁNCER ORAL</dc:subject>
<dc:subject>MUCOSITIS</dc:subject>
<dc:subject>HISTAMINA</dc:subject>
<dc:subject>TEJIDO PRECANCEROSO</dc:subject>
<dc:description>Abstract: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the thera- peutic effect of BNCT mediated by BPA (boronophenyla- lanine) in the hamster cheek pouch model of oral cancer, at the RA-6 nuclear reactor. Between 2007 and 2011, the RA-6 was upgraded, leading to an improvement in the per- formance of the BNCT beam (B2 configuration). Our aim was to evaluate BPA-BNCT radiotoxicity and tumor control in the hamster cheek pouch model of oral cancer at the new “B2” configuration. We also evaluated, for the first time in the oral cancer model, the radioprotective effect of histamine against mucositis in precancerous tissue as the dose-limiting tissue. Cancerized pouches were exposed to: BPA-BNCT; BPA-BNCT + histamine; BO: Beam only; BO + histamine; CONTROL: cancerized, no-treatment. BNCT induced severe mucositis, with an incidence that was slightly higher than in “B1” experiments (86 vs 67%, respectively). BO induced low/moderate mucositis. Histamine slightly reduced the incidence of severe mucositis induced by BPA-BNCT (75 vs 86%) and prevented mucositis altogether in BO animals. Tumor overall response was significantly higher in BNCT (94– 96%) than in control (16%) and BO groups (9–38%), and did not differ significantly from the “B1” results (91%). Histamine did not compromise BNCT therapeutic efficacy. BNCT radiotoxicity and therapeutic effect at the B1 and B2 configurations of RA-6 were consistent. Histamine slightly reduced mucositis in precancerous tissue even in this overly aggressive oral cancer model, without compromising tumor control.</dc:description>
<dc:date>2021-03-01T11:54:11Z</dc:date>
<dc:date>2021-03-01T11:54:11Z</dc:date>
<dc:date>2017</dc:date>
<dc:type>Artículo</dc:type>
<dc:identifier>Monti Hughe, A., Longhino, J., Boggio, E., Medin, V. A., Martinel Lamas, D. J., Garabalin, M. A., Heber, E. M., Pozzi, E. C. C., Itoiz, M. E., Aromando, R. F., Nigg, D. W., Trivillin, V. A., Schwint, A. E. Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor [en línea]. 2017. Radiat Environ Biophys 56 (4). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11230</dc:identifier>
<dc:identifier>https://repositorio.uca.edu.ar/handle/123456789/11230</dc:identifier>
<dc:identifier>10.1007/s00411-017-0710-9</dc:identifier>
<dc:language>eng</dc:language>
<dc:rights>Acceso abierto</dc:rights>
<dc:rights>http://creativecommons.org/licenses/by-nc-sa/4.0/</dc:rights>
<dc:format>application/pdf</dc:format>
<dc:publisher>Springer Nature</dc:publisher>
<dc:source>Radiat Environ Biophys Vol.56, No.4, 2017</dc:source>
</oai_dc:dc>
Datos convertidos
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],
"topic": [
"TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT)",
"CONFIGURACION RA-6",
"BOLSA DE MEJILLA DE HAMSTER MODELO DE C\u00c1NCER ORAL",
"MUCOSITIS",
"HISTAMINA",
"TEJIDO PRECANCEROSO"
],
"spellingShingle": [
"TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT)",
"CONFIGURACION RA-6",
"BOLSA DE MEJILLA DE HAMSTER MODELO DE C\u00c1NCER ORAL",
"MUCOSITIS",
"HISTAMINA",
"TEJIDO PRECANCEROSO",
"Monti Hughe, Andrea",
"Longhino, Juan",
"Boggio, Esteban",
"Medin, Vanina A.",
"Martinel Lamas, Diego Jos\u00e9",
"Garabalin, Marcela A.",
"Heber, Elisa M.",
"Pozzi, Emiliano C. C.",
"Itoiz, Mar\u00eda E.",
"Aromando, Romina F.",
"Nigg, David W.",
"Trivillin, Ver\u00f3nica A.",
"Schwint, Amanda E.",
"Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor"
],
"topic_facet": [
"TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT)",
"CONFIGURACION RA-6",
"BOLSA DE MEJILLA DE HAMSTER MODELO DE C\u00c1NCER ORAL",
"MUCOSITIS",
"HISTAMINA",
"TEJIDO PRECANCEROSO"
],
"description": "Abstract: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the thera- peutic effect of BNCT mediated by BPA (boronophenyla- lanine) in the hamster cheek pouch model of oral cancer, at the RA-6 nuclear reactor. Between 2007 and 2011, the RA-6 was upgraded, leading to an improvement in the per- formance of the BNCT beam (B2 configuration). Our aim was to evaluate BPA-BNCT radiotoxicity and tumor control in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration. We also evaluated, for the first time in the oral cancer model, the radioprotective effect of histamine against mucositis in precancerous tissue as the dose-limiting tissue. Cancerized pouches were exposed to: BPA-BNCT; BPA-BNCT + histamine; BO: Beam only; BO + histamine; CONTROL: cancerized, no-treatment. BNCT induced severe mucositis, with an incidence that was slightly higher than in \u201cB1\u201d experiments (86 vs 67%, respectively). BO induced low\/moderate mucositis. Histamine slightly reduced the incidence of severe mucositis induced by BPA-BNCT (75 vs 86%) and prevented mucositis altogether in BO animals. Tumor overall response was significantly higher in BNCT (94\u2013 96%) than in control (16%) and BO groups (9\u201338%), and did not differ significantly from the \u201cB1\u201d results (91%). Histamine did not compromise BNCT therapeutic efficacy. BNCT radiotoxicity and therapeutic effect at the B1 and B2 configurations of RA-6 were consistent. Histamine slightly reduced mucositis in precancerous tissue even in this overly aggressive oral cancer model, without compromising tumor control.",
"format": [
"Art\u00edculo"
],
"author": [
"Monti Hughe, Andrea",
"Longhino, Juan",
"Boggio, Esteban",
"Medin, Vanina A.",
"Martinel Lamas, Diego Jos\u00e9",
"Garabalin, Marcela A.",
"Heber, Elisa M.",
"Pozzi, Emiliano C. C.",
"Itoiz, Mar\u00eda E.",
"Aromando, Romina F.",
"Nigg, David W.",
"Trivillin, Ver\u00f3nica A.",
"Schwint, Amanda E."
],
"author_facet": [
"Monti Hughe, Andrea",
"Longhino, Juan",
"Boggio, Esteban",
"Medin, Vanina A.",
"Martinel Lamas, Diego Jos\u00e9",
"Garabalin, Marcela A.",
"Heber, Elisa M.",
"Pozzi, Emiliano C. C.",
"Itoiz, Mar\u00eda E.",
"Aromando, Romina F.",
"Nigg, David W.",
"Trivillin, Ver\u00f3nica A.",
"Schwint, Amanda E."
],
"author_sort": "Monti Hughe, Andrea",
"title": "Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor",
"title_short": "Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor",
"title_full": "Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor",
"title_fullStr": "Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor",
"title_full_unstemmed": "Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cB2\u201d configuration of the RA\u20116 nuclear reactor",
"title_sort": "boron neutron capture therapy (bnct) translational studies in the hamster cheek pouch model of oral cancer at the new \u201cb2\u201d configuration of the ra\u20116 nuclear reactor",
"publisher": [
"Springer Nature"
],
"publishDate": [
"2021"
],
"url": [
"https:\/\/repositorio.uca.edu.ar\/handle\/123456789\/11230"
],
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