Herramienta de chequeo de registro xml obtenido desde Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)

XML

<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:doc="http://www.lyncode.com/xoai" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>I15-R121-2133-9378</identifier><datestamp>2017-11-23T18:44:12Z</datestamp>
<dc:title>Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity</dc:title>
<dc:creator>Capitaine Funes, Juan</dc:creator>
<dc:creator>Massa, Estefania</dc:creator>
<dc:creator>Cipulli, Germán</dc:creator>
<dc:creator>Benitez Gil, Alfonso</dc:creator>
<dc:creator>Capitaine Funes, Carlos</dc:creator>
<dc:creator>Tozzini, Roberto</dc:creator>
<dc:creator>Ghersevich, Sergio</dc:creator>
<dc:creator>Ceballos, María Paula</dc:creator>
<dc:subject>Ensayo cometa</dc:subject>
<dc:subject>Daño genotóxico</dc:subject>
<dc:subject>Cáncer mamas</dc:subject>
<dc:subject>Factor pronóstico</dc:subject>
<dc:subject>Peripheral blood lymphocytes</dc:subject>
<dc:subject>Comet assay</dc:subject>
<dc:subject>Genotoxic damage</dc:subject>
<dc:description>It is accepted that radiotherapy and chemotherapy cause genotoxic effects as part of their therapy side effects, which are highly variable among different patients. This study evaluated DNA integrity using the comet assay in peripheral blood lymphocytes from breast cancer patients before (“pre-treatment patients”; n = 47) and after (“post-treatment patients”; n = 24) radiotherapy and/or chemotherapy treatment and from healthy donors (n = 15). Comet evaluation was made by visual (types 0-4) and digital (percentage of DNA remaining in the comet head = % head DNA) analysis. The association between the level of DNA damage and cancer prognostic factors was assessed. The treatments caused a significant increase in DNA damage registered by both visual (p &lt; 0.001) and digital (p &lt; 0.001) analysis. No significant associations between the level of DNA damage in pre-treatment patients and cancer prognostic factors were found. Results showed a significant correlation between the comet results from each patient before and after treatment (r = 0.64, p = 0.001). The % head DNA in post-treatment samples from patients with high level of DNA damage before treatment (30.3 ± 3.1%, p &lt; 0.01) was lower than in post-treatment samples from patient with low to medium level of DNA damage before therapy (49.2 ± 4.4%). Results support the usefulness of the comet assay as a sensitive technique to evaluate the basal DNA status and the damage caused by cancer treatments. The assay could contribute to the treatment decisions, taking into account the patients’ basal DNA damage before therapy.</dc:description>
<dc:description>Fil: Capitaine Funes, Juan. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina</dc:description>
<dc:description>Fil: Ceballos, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (UNR-CONICET); Argentina</dc:description>
<dc:description>Fil: Capitaine Funes, Juan. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastología; Argentina</dc:description>
<dc:description>Fil: Massa, Estefania. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina</dc:description>
<dc:description>Fil: Cipulli, Germán. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastología; Argentina</dc:description>
<dc:description>Fil: Benitez Gil, Alfonso. Provincia de Santa Fe. Hospital Provincial. Servicio de Mastología; Argentina</dc:description>
<dc:description>Fil: Capitaine Funes, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina</dc:description>
<dc:description>Fil: Capitaine Funes, Carlos. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastología; Argentina</dc:description>
<dc:description>Fil: Tozzini, Roberto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina</dc:description>
<dc:description>Fil: Tozzini, Roberto. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastología; Argentina</dc:description>
<dc:description>Fil: Ghersevich, Sergio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina</dc:description>
<dc:date>2017-11-23T18:41:19Z</dc:date>
<dc:date>2017-11-23T18:41:19Z</dc:date>
<dc:date>2014-04-15</dc:date>
<dc:date>2017-11-23T18:41:19Z</dc:date>
<dc:date>2017-11-23T18:41:19Z</dc:date>
<dc:date>2014-04-15</dc:date>
<dc:type>article</dc:type>
<dc:type>artículo</dc:type>
<dc:type>acceptedVersion</dc:type>
<dc:identifier>0731-8898</dc:identifier>
<dc:identifier>http://hdl.handle.net/2133/9378</dc:identifier>
<dc:identifier>http://hdl.handle.net/2133/9378</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>http://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,249005dc454eb8de,570be1034750e71e.html</dc:relation>
<dc:relation>DOI: 10.1615/JEnvironPatholToxicolOncol.2014010592</dc:relation>
<dc:rights>Begell House Inc.</dc:rights>
<dc:rights>Ceballos, María Paula</dc:rights>
<dc:rights>Capitaine Funes, Juan</dc:rights>
<dc:rights>Massa, Estefanía</dc:rights>
<dc:rights>Cipulli, Germán</dc:rights>
<dc:rights>Benitez Gil, Alfonso</dc:rights>
<dc:rights>Capitaine Funes, Carlos</dc:rights>
<dc:rights>Tozzini, Roberto</dc:rights>
<dc:rights>Ghersevich, Sergio</dc:rights>
<dc:rights>openAccess</dc:rights>
<dc:format>application/pdf</dc:format>
<dc:publisher>BEGELL HOUSE INC</dc:publisher>
</oai_dc:dc>

Datos convertidos

{
    "id": "I15-R121-2133-9378",
    "record_format": "dspace",
    "spelling": [
        "I15-R121-2133-93782017-11-23T18:44:12Z Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity Capitaine Funes, Juan Massa, Estefania Cipulli, Germ\u00e1n Benitez Gil, Alfonso Capitaine Funes, Carlos Tozzini, Roberto Ghersevich, Sergio Ceballos, Mar\u00eda Paula Ensayo cometa Da\u00f1o genot\u00f3xico C\u00e1ncer mamas Factor pron\u00f3stico Peripheral blood lymphocytes Comet assay Genotoxic damage It is accepted that radiotherapy and chemotherapy cause genotoxic effects as part of their therapy side effects, which are highly variable among different patients. This study evaluated DNA integrity using the comet assay in peripheral blood lymphocytes from breast cancer patients before (\u201cpre-treatment patients\u201d; n = 47) and after (\u201cpost-treatment patients\u201d; n = 24) radiotherapy and\/or chemotherapy treatment and from healthy donors (n = 15). Comet evaluation was made by visual (types 0-4) and digital (percentage of DNA remaining in the comet head = % head DNA) analysis. The association between the level of DNA damage and cancer prognostic factors was assessed. The treatments caused a significant increase in DNA damage registered by both visual (p < 0.001) and digital (p < 0.001) analysis. No significant associations between the level of DNA damage in pre-treatment patients and cancer prognostic factors were found. Results showed a significant correlation between the comet results from each patient before and after treatment (r = 0.64, p = 0.001). The % head DNA in post-treatment samples from patients with high level of DNA damage before treatment (30.3 \u00b1 3.1%, p < 0.01) was lower than in post-treatment samples from patient with low to medium level of DNA damage before therapy (49.2 \u00b1 4.4%). Results support the usefulness of the comet assay as a sensitive technique to evaluate the basal DNA status and the damage caused by cancer treatments. The assay could contribute to the treatment decisions, taking into account the patients\u2019 basal DNA damage before therapy. Fil: Capitaine Funes, Juan. Universidad Nacional de Rosario. Facultad de Ciencias M\u00e9dicas; Argentina Fil: Ceballos, Mar\u00eda Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas. Instituto de Fisiolog\u00eda Experimental (UNR-CONICET); Argentina Fil: Capitaine Funes, Juan. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastolog\u00eda; Argentina Fil: Massa, Estefania. Universidad Nacional de Rosario. Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas; Argentina Fil: Cipulli, Germ\u00e1n. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastolog\u00eda; Argentina Fil: Benitez Gil, Alfonso. Provincia de Santa Fe. Hospital Provincial. Servicio de Mastolog\u00eda; Argentina Fil: Capitaine Funes, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias M\u00e9dicas; Argentina Fil: Capitaine Funes, Carlos. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastolog\u00eda; Argentina Fil: Tozzini, Roberto. Universidad Nacional de Rosario. Facultad de Ciencias M\u00e9dicas; Argentina Fil: Tozzini, Roberto. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Mastolog\u00eda; Argentina Fil: Ghersevich, Sergio. Universidad Nacional de Rosario. Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas; Argentina 2017-11-23T18:41:19Z 2017-11-23T18:41:19Z 2014-04-15 2017-11-23T18:41:19Z 2017-11-23T18:41:19Z 2014-04-15 article art\u00edculo acceptedVersion 0731-8898 http:\/\/hdl.handle.net\/2133\/9378 http:\/\/hdl.handle.net\/2133\/9378 eng http:\/\/www.dl.begellhouse.com\/journals\/0ff459a57a4c08d0,249005dc454eb8de,570be1034750e71e.html DOI: 10.1615\/JEnvironPatholToxicolOncol.2014010592 Begell House Inc. Ceballos, Mar\u00eda Paula Capitaine Funes, Juan Massa, Estefan\u00eda Cipulli, Germ\u00e1n Benitez Gil, Alfonso Capitaine Funes, Carlos Tozzini, Roberto Ghersevich, Sergio openAccess application\/pdf BEGELL HOUSE INC"
    ],
    "institution": [
        "Universidad Nacional de Rosario"
    ],
    "institution_str": "I-15",
    "repository_str": "R-121",
    "collection": [
        "Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)"
    ],
    "language": [
        "Ingl\u00e9s"
    ],
    "orig_language_str_mv": [
        "eng"
    ],
    "topic": [
        "Ensayo cometa",
        "Da\u00f1o genot\u00f3xico",
        "C\u00e1ncer mamas",
        "Factor pron\u00f3stico",
        "Peripheral blood lymphocytes",
        "Comet assay",
        "Genotoxic damage"
    ],
    "spellingShingle": [
        "Ensayo cometa",
        "Da\u00f1o genot\u00f3xico",
        "C\u00e1ncer mamas",
        "Factor pron\u00f3stico",
        "Peripheral blood lymphocytes",
        "Comet assay",
        "Genotoxic damage",
        "Capitaine Funes, Juan",
        "Massa, Estefania",
        "Cipulli, Germ\u00e1n",
        "Benitez Gil, Alfonso",
        "Capitaine Funes, Carlos",
        "Tozzini, Roberto",
        "Ghersevich, Sergio",
        "Ceballos, Mar\u00eda Paula",
        "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity"
    ],
    "topic_facet": [
        "Ensayo cometa",
        "Da\u00f1o genot\u00f3xico",
        "C\u00e1ncer mamas",
        "Factor pron\u00f3stico",
        "Peripheral blood lymphocytes",
        "Comet assay",
        "Genotoxic damage"
    ],
    "description": "It is accepted that radiotherapy and chemotherapy cause genotoxic effects as part of their therapy side effects, which are highly variable among different patients. This study evaluated DNA integrity using the comet assay in peripheral blood lymphocytes from breast cancer patients before (\u201cpre-treatment patients\u201d; n = 47) and after (\u201cpost-treatment patients\u201d; n = 24) radiotherapy and\/or chemotherapy treatment and from healthy donors (n = 15). Comet evaluation was made by visual (types 0-4) and digital (percentage of DNA remaining in the comet head = % head DNA) analysis. The association between the level of DNA damage and cancer prognostic factors was assessed. The treatments caused a significant increase in DNA damage registered by both visual (p < 0.001) and digital (p < 0.001) analysis. No significant associations between the level of DNA damage in pre-treatment patients and cancer prognostic factors were found. Results showed a significant correlation between the comet results from each patient before and after treatment (r = 0.64, p = 0.001). The % head DNA in post-treatment samples from patients with high level of DNA damage before treatment (30.3 \u00b1 3.1%, p < 0.01) was lower than in post-treatment samples from patient with low to medium level of DNA damage before therapy (49.2 \u00b1 4.4%). Results support the usefulness of the comet assay as a sensitive technique to evaluate the basal DNA status and the damage caused by cancer treatments. The assay could contribute to the treatment decisions, taking into account the patients\u2019 basal DNA damage before therapy.",
    "format": [
        "article",
        "art\u00edculo",
        "acceptedVersion"
    ],
    "author": [
        "Capitaine Funes, Juan",
        "Massa, Estefania",
        "Cipulli, Germ\u00e1n",
        "Benitez Gil, Alfonso",
        "Capitaine Funes, Carlos",
        "Tozzini, Roberto",
        "Ghersevich, Sergio",
        "Ceballos, Mar\u00eda Paula"
    ],
    "author_facet": [
        "Capitaine Funes, Juan",
        "Massa, Estefania",
        "Cipulli, Germ\u00e1n",
        "Benitez Gil, Alfonso",
        "Capitaine Funes, Carlos",
        "Tozzini, Roberto",
        "Ghersevich, Sergio",
        "Ceballos, Mar\u00eda Paula"
    ],
    "author_sort": "Capitaine Funes, Juan",
    "title": "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity",
    "title_short": "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity",
    "title_full": "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity",
    "title_fullStr": "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity",
    "title_full_unstemmed": "Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity",
    "title_sort": "relationship between genotoxic effects of breast cancer treatments and patient basal dna integrity",
    "publisher": [
        "BEGELL HOUSE INC"
    ],
    "publishDate": [
        "2017"
    ],
    "url": [
        "http:\/\/hdl.handle.net\/2133\/9378",
        "http:\/\/hdl.handle.net\/2133\/9378"
    ],
    "work_keys_str_mv": [
        "AT capitainefunesjuan relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT massaestefania relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT cipulligerman relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT benitezgilalfonso relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT capitainefunescarlos relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT tozziniroberto relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT ghersevichsergio relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity",
        "AT ceballosmariapaula relationshipbetweengenotoxiceffectsofbreastcancertreatmentsandpatientbasaldnaintegrity"
    ],
    "_version_": 1734086309219139584
}