XML
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:doc="http://www.lyncode.com/xoai" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>I19-R120-10915-18126</identifier><datestamp>2019-07-06T04:03:10Z</datestamp>
<dc:identifier>http://sedici.unlp.edu.ar/handle/10915/18126</dc:identifier>
<dc:identifier>http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf</dc:identifier>
<dc:identifier>issn:0326-2383</dc:identifier>
<dc:title>Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits</dc:title>
<dc:creator>Rule, Roberto</dc:creator>
<dc:creator>Petinelli, A.</dc:creator>
<dc:creator>Cordiviola, Carlos Ángel</dc:creator>
<dc:creator>Prozzi, Guillermo Rafael</dc:creator>
<dc:creator>Farina, Osvaldo Hugo</dc:creator>
<dc:creator>Villagra, Sergio</dc:creator>
<dc:date>2012</dc:date>
<dc:date>2012-05-16T19:40:05Z</dc:date>
<dc:language>en</dc:language>
<dc:subject>Farmacia</dc:subject>
<dc:subject>Fenómenos Bioquímicos</dc:subject>
<dc:subject>cefepime; pharmacokinetics; rabbits; safety</dc:subject>
<dc:subject>Farmacocinética</dc:subject>
<dc:description>The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification.</dc:description>
<dc:description>Colegio de Farmacéuticos de la Provincia de Buenos Aires</dc:description>
<dc:type>Articulo</dc:type>
<dc:type>Articulo</dc:type>
<dc:format>application/pdf</dc:format>
<dc:format>287-291</dc:format>
</oai_dc:dc>
Datos convertidos
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"language": [
"Ingl\u00e9s"
],
"topic": [
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"Fen\u00f3menos Bioqu\u00edmicos",
"cefepime; pharmacokinetics; rabbits; safety",
"Farmacocin\u00e9tica"
],
"spellingShingle": [
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"Villagra, Sergio",
"Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits"
],
"topic_facet": [
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"Fen\u00f3menos Bioqu\u00edmicos",
"cefepime; pharmacokinetics; rabbits; safety",
"Farmacocin\u00e9tica"
],
"description": "The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg\/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg\/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean \u00b1 S.D.) were: t\u00bd = 1.6 \u00b1 0.4 h; AUC = 212.1 \u00b1 82.1 \u03bcg\/mL.h; AUMC = 387.4 \u00b1 132.2 \u03bcg\/mL.h; Vss = 216.7 \u00b1 63.4 mL\/kg; CL = 99.7 \u00b1 19.4 mL\/kg y TMR = 2.0 \u00b1 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification.",
"format": [
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"author": [
"Rule, Roberto",
"Petinelli, A.",
"Cordiviola, Carlos \u00c1ngel",
"Prozzi, Guillermo Rafael",
"Farina, Osvaldo Hugo",
"Villagra, Sergio"
],
"author_facet": [
"Rule, Roberto",
"Petinelli, A.",
"Cordiviola, Carlos \u00c1ngel",
"Prozzi, Guillermo Rafael",
"Farina, Osvaldo Hugo",
"Villagra, Sergio"
],
"author_sort": "Rule, Roberto",
"title": "Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits",
"title_short": "Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits",
"title_full": "Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits",
"title_fullStr": "Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits",
"title_full_unstemmed": "Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits",
"title_sort": "pharmacokinetics and evaluation of the safety of cefepime administered to rabbits",
"publishDate": [
"2012"
],
"url": [
"http:\/\/sedici.unlp.edu.ar\/handle\/10915\/18126",
"http:\/\/www.latamjpharm.org\/resumenes\/31\/2\/LAJOP_31_2_1_17.pdf"
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