enzyme active site 140 article 118 nonhuman 90 priority journal 76 controlled study 66 Catalytic Domain 48 enzyme activity 48 unclassified drug 48 metabolism 38 Animals 32 Kinetics 32 Models, Molecular 32 cyclic AMP dependent protein kinase 32 Binding Sites 28 chemistry 26 Enzyme Activation 24 Molecular Sequence Data 24 Saccharomyces cerevisiae 24 amino acid sequence 24 enzyme activation 24 Enzymes 22 Humans 22 Phosphorylation 22 binding site 22 catalysis 22 enzyme structure 22 enzymology 22 molecular dynamics 22 nucleotide sequence 22 Amino Acid Sequence 20