Calorimetry 1 Chagas disease 1 Crystallography, X-Ray 1 Drug Design 1 Enzyme Inhibitors 1 Geranyltranstransferase 1 IC 50 1 Magnesium 1 Models, Molecular 1 Phosphonic Acids 1 Protein Conformation 1 Thermodynamics 1 Trypanosoma cruzi 1 X ray crystallography 1 alkyl group 1 allyl compound 1 amine 1 antitrypanosomal agent 1 article 1 binding affinity 1 bisphosphonic acid derivative 1 chemical bond 1 complex formation 1 conformation 1 crystal structure 1 drug design 1 drug protein binding 1 drug synthesis 1 enthalpy 1 entropy 1