gain of function mutation mouse 8 nonhuman 8 Animals 6 Mice 6 Mice, Transgenic 6 unclassified drug 6 Calcium Channels, N-Type 4 Humans 4 Migraine with Aura 4 Mutation 4 Synaptic transmission 4 animal 4 animal tissue 4 article 4 controlled study 4 enzyme activation 4 familial hemiplegic migraine 4 genetics 4 hyperpolarization 4 male 4 nerve cell plasticity 4 neurotransmitter release 4 pathophysiology 4 phenotype 4 priority journal 4 synapse 4 synaptic transmission 4 transgenic mouse 4 voltage gated calcium channel 4