enzyme structure article 44 priority journal 36 nonhuman 34 unclassified drug 30 enzyme activity 24 controlled study 22 enzyme active site 22 Humans 18 human 18 Article 16 Animals 14 Crystallography, X-Ray 14 Kinetics 14 catalysis 14 chemistry 14 molecular dynamics 12 structure analysis 12 Models, Molecular 10 Protein Binding 10 Trypanosoma cruzi 10 conformational transition 10 enzyme mechanism 10 metabolism 10 protein domain 10 signal transduction 10 Amino acids 8 Catalysis 8 Catalytic Domain 8 Enzyme Activation 8