enzyme inhibition nonhuman 166 enzyme activity 164 article 162 controlled study 144 priority journal 134 Animals 118 unclassified drug 80 animal tissue 58 enzyme activation 54 human 54 signal transduction 54 animal experiment 50 Humans 48 animal cell 48 Enzyme Inhibitors 42 protein expression 40 human cell 38 metabolism 38 Trypanosoma cruzi 36 animal 36 mouse 36 concentration response 34 Enzyme Activation 32 protein phosphorylation 32 Mice 30 rat 30 male 28 Cell Line, Tumor 26 Rats 26