enzyme activation signal transduction 152 priority journal 148 article 144 controlled study 134 nonhuman 132 Animals 108 Signal Transduction 108 animal cell 94 human 78 Humans 74 Enzyme Activation 70 metabolism 68 mouse 66 mitogen activated protein kinase 64 Mice 62 mitogen activated protein kinase 1 62 protein expression 62 human cell 58 Phosphorylation 50 animal 50 enzyme activity 50 Female 48 mitogen activated protein kinase 3 48 protein phosphorylation 46 phosphatidylinositol 3 kinase 44 unclassified drug 44 protein kinase B 42 female 40 cell proliferation 38