drug mechanism nonhuman 282 article 222 priority journal 218 controlled study 202 Animals 188 unclassified drug 146 animal experiment 138 animal cell 134 human 102 mouse 92 Humans 86 Mice 84 Male 80 animal model 76 Female 74 rat 74 in vitro study 72 male 72 animal tissue 68 Rats 66 drug effect 66 dose response 54 animal 52 human cell 52 protein expression 52 female 50 drug structure 48 Dose-Response Relationship, Drug 42 antiviral activity 42