down regulation mouse nonhuman 94 controlled study 92 Animals 90 Mice 78 priority journal 74 animal cell 64 animal 62 animal experiment 60 metabolism 58 article 54 animal tissue 50 female 50 protein expression 48 Female 46 Article 42 animal model 42 Humans 40 human 40 genetics 38 unclassified drug 36 messenger RNA 34 upregulation 34 gene expression regulation 32 signal transduction 30 gene expression 28 Down-Regulation 24 apoptosis 24 Mice, Inbred BALB C 22