cognitive defect human 44 priority journal 40 article 36 male 36 female 28 controlled study 26 Humans 22 adult 22 aged 22 Alzheimer disease 18 Male 18 major clinical study 16 neuropsychological test 16 physiology 16 Alzheimer Disease 14 Hippocampus 14 clinical article 14 hippocampus 14 learning 14 Animals 12 Article 12 Cognition Disorders 12 Neuropsychological Tests 12 animal 12 animal experiment 12 depression 12 metabolism 12 mouse 12 nonhuman 12