article enzyme active site 118 nonhuman 78 priority journal 68 controlled study 60 unclassified drug 42 Catalytic Domain 38 enzyme activity 36 Animals 30 Kinetics 28 cyclic AMP dependent protein kinase 28 Models, Molecular 26 metabolism 26 Binding Sites 24 Enzyme Activation 24 Molecular Sequence Data 24 enzyme activation 24 Saccharomyces cerevisiae 22 nucleotide sequence 22 Humans 20 Phosphorylation 20 catalysis 20 Amino Acid Sequence 18 Enzymes 18 amino acid sequence 18 human 18 molecular dynamics 18 protein phosphorylation 18 Cyclic AMP-Dependent Protein Kinases 16 Mammalia 16