Humans human 260 article 246 controlled study 224 priority journal 224 enzyme activity 222 human cell 152 Animals 146 nonhuman 146 enzyme activation 112 unclassified drug 108 metabolism 100 signal transduction 100 protein expression 92 Mice 76 mouse 76 Female 72 Cell Line, Tumor 68 cell proliferation 68 animal cell 66 Signal Transduction 58 Article 56 animal 56 apoptosis 56 female 54 Enzyme Activation 50 enzyme inhibition 48 Male 46 protein function 46 animal experiment 44