enzyme activity 633 article 604 nonhuman 586 controlled study 463 priority journal 449 Animals 318 unclassified drug 213 metabolism 208 animal experiment 183 enzyme activation 177 animal tissue 176 animal cell 162 human 162 Humans 144 male 143 protein expression 138 mouse 134 Article 130 rat 123 signal transduction 123 animal 117 female 112 Mice 111 Female 107 Enzyme Activation 105 Male 102 Rats 100 human cell 100 enzyme inhibition 92 animal model 89